5DNM
 
 | | Nucleosome core particle containing adducts of ruthenium(II)-toluene PTA complex | | 分子名称: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | | 著者 | Adhireksan, Z, Muhammad, R, Davey, C.A. | | 登録日 | 2015-09-10 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Allosteric cross-talk in chromatin can mediate drug-drug synergy
Nat Commun, 8, 2017
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5DNN
 | | Nucleosome core particle containing adducts of gold(I)-triethylphosphane and ruthenium(II)-toluene PTA complexes | | 分子名称: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | | 著者 | Adhireksan, Z, Ma, Z, Davey, C.A. | | 登録日 | 2015-09-10 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Allosteric cross-talk in chromatin can mediate drug-drug synergy
Nat Commun, 8, 2017
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6KD0
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4ENO
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5FHI
 | | Crystallographic structure of PsoE without Co | | 分子名称: | GLUTATHIONE, Glutathione S-transferase, putative | | 著者 | Hara, K, Hashimoto, H, Yamamoto, T, Tsunematsu, Y, Watanabe, K. | | 登録日 | 2015-12-22 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.
Angew. Chem. Int. Ed. Engl., 55, 2016
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7YJ0
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8GB2
 | | Crystal structure of Apo-SAMHD1 | | 分子名称: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION | | 著者 | Egleston, M, Dong, L, Howlader, A.H, Bhat, S, Orris, B, Bianchet, M.A, Greenberg, M.M, Stivers, J.T. | | 登録日 | 2023-02-24 | | 公開日 | 2023-06-07 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | | 主引用文献 | Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding.
Acs Chem.Biol., 18, 2023
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1L1L
 | | CRYSTAL STRUCTURE OF B-12 DEPENDENT (CLASS II) RIBONUCLEOTIDE REDUCTASE | | 分子名称: | RIBONUCLEOSIDE TRIPHOSPHATE REDUCTASE | | 著者 | Sintchak, M.D, Arjara, G, Kellogg, B.A, Stubbe, J, Drennan, C.L. | | 登録日 | 2002-02-18 | | 公開日 | 2002-04-10 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimer.
Nat.Struct.Biol., 9, 2002
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4DO9
 | | Ternary complex of dna polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-monofluoromethylene triphosphate: stereoselective binding of r-isomer | | 分子名称: | 2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE, C C G A C C G C G C A T C A G C, CHLORIDE ION, ... | | 著者 | Batra, V.K. | | 登録日 | 2012-02-09 | | 公開日 | 2012-06-13 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Beta,gamma-CHF- and beta,gamma-CHCl-dGTP Diastereomers: Synthesis, Discrete (31)P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases
J.Am.Chem.Soc., 134, 2012
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5F8B
 | | Crystallographic Structure of PsoE with Co | | 分子名称: | (5~{S},8~{S},9~{R})-2-[(~{E})-hex-1-enyl]-8-methoxy-3-methyl-9-oxidanyl-8-(phenylcarbonyl)-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, COBALT (II) ION, GLUTATHIONE, ... | | 著者 | Hara, K, Hashimoto, H, Yamamoto, T, Tsunematsu, Y, Watanabe, K. | | 登録日 | 2015-12-09 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.
Angew. Chem. Int. Ed. Engl., 55, 2016
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4DOB
 | | Ternary complex of DNA polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-monochlororomethylene triphosphate: Stereoselective binding of R-isomer | | 分子名称: | 5'-O-[(R)-{[(R)-[(R)-chloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2'-deoxyguanosine, C C G A C C G C G C A T C A G C, CHLORIDE ION, ... | | 著者 | Batra, V.K. | | 登録日 | 2012-02-09 | | 公開日 | 2012-06-13 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Beta,Gamma-CHF- and beta,gamma-CHCl-dGTP Diastereomers: Synthesis, Discrete (31)P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases
J.Am.Chem.Soc., 134, 2012
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3VVU
 | | Crystal structure of reconstructed bacterial ancestral NDK, Bac1 | | 分子名称: | Nucleoside diphosphate kinase | | 著者 | Nemoto, N, Miyazono, K, Kimura, M, Yokobori, S, Akanuma, S, Tanokura, M, Yamagishi, A. | | 登録日 | 2012-07-27 | | 公開日 | 2013-06-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Experimental evidence for the thermophilicity of ancestral life
Proc.Natl.Acad.Sci.USA, 110, 2013
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3VVT
 | | Crystal structure of reconstructed archaeal ancestral NDK, Arc1 | | 分子名称: | Nucleoside diphosphate kinase | | 著者 | Nemoto, N, Miyazono, K, Kimura, M, Yokobori, S, Akanuma, S, Tanokura, M, Yamagishi, A. | | 登録日 | 2012-07-27 | | 公開日 | 2013-06-19 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Experimental evidence for the thermophilicity of ancestral life
Proc.Natl.Acad.Sci.USA, 110, 2013
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7C7X
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5IKF
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7BP4
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7BP6
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7BP2
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7BP5
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4RXS
 | | The structure of GTP-dTTP-bound SAMHD1 | | 分子名称: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Zhu, C.F, Wei, W, Peng, X, Dong, Y.H, Gong, Y, Yu, X.F. | | 登録日 | 2014-12-11 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
Acta Crystallogr.,Sect.D, 71, 2015
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4RXO
 | | The structure of GTP-bound SAMHD1 | | 分子名称: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, ... | | 著者 | Zhu, C.F, Wei, W, Peng, X, Dong, Y.H, Gong, Y, Yu, X.F. | | 登録日 | 2014-12-11 | | 公開日 | 2015-03-11 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
Acta Crystallogr.,Sect.D, 71, 2015
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7KTQ
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4CC9
 | | Crystal structure of human SAMHD1 (amino acid residues 582-626) bound to Vpx isolated from sooty mangabey and human DCAF1 (amino acid residues 1058-1396) | | 分子名称: | DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1, PROTEIN VPRBP, PROTEIN VPX, ... | | 著者 | Schwefel, D, Groom, H.C.T, Boucherit, V.C, Christodoulou, E, Walker, P.A, Stoye, J.P, Bishop, K.N, Taylor, I.A. | | 登録日 | 2013-10-19 | | 公開日 | 2013-12-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.473 Å) | | 主引用文献 | Structural Basis of Lentiviral Subversion of a Cellular Protein Degradation Pathway.
Nature, 505, 2014
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8TDW
 | | ssRNA bound SAMHD1 T open | | 分子名称: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, RNA (5'-R(P*CP*CP*GP*AP*CP*C)-3'), ... | | 著者 | Sung, M, Huynh, K, Han, S. | | 登録日 | 2023-07-05 | | 公開日 | 2023-11-22 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1.
Nucleic Acids Res., 51, 2023
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8TDV
 | | ssRNA bound SAMHD1 T closed | | 分子名称: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, RNA (5'-R(P*CP*CP*GP*AP*CP*CP*C)-3'), ... | | 著者 | Sung, M, Huynh, K, Han, S. | | 登録日 | 2023-07-05 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1.
Nucleic Acids Res., 51, 2023
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