7XXU
 
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9HDM
 | | Crystal structure of Pyrimidine Nucleoside 2'-Hydroxylase (PDN2'H) from Neurospora crassa in complex with thymidine | | 分子名称: | (R,R)-2,3-BUTANEDIOL, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | 著者 | Friedrich, F, Genz, F, Einsle, O, Mueller, M, Fessner, N.D. | | 登録日 | 2024-11-12 | | 公開日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Identification and Characterization of Pyrimidine Nucleoside 2'-Hydroxylase
Acs Catalysis, 2025
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9HDL
 | | Crystal structure of Pyrimidine Nucleoside 2'-Hydroxylase (PDN2'H) from Neurospora crassa | | 分子名称: | Clavaminate synthase-like protein, FE (III) ION | | 著者 | Friedrich, F, Genz, F, Einsle, O, Mueller, M, Fessner, N.D. | | 登録日 | 2024-11-12 | | 公開日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Identification and Characterization of Pyrimidine Nucleoside 2'-Hydroxylase
Acs Catalysis, 2025
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6Y1N
 | | Crystal structure of the phosphonate-modified A.5 antibody FAB fragment | | 分子名称: | 8-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-YL PHENYLPHOSPHONATE, FAB A.5 Heavy chain, FAB A.5 Light Chain | | 著者 | Chatziefthimiou, S, Mokrushina, Y, Smirnov, I, Gabibov, A, Wilmanns, M. | | 登録日 | 2020-02-12 | | 公開日 | 2020-09-23 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers.
Proc.Natl.Acad.Sci.USA, 117, 2020
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9H8L
 | | Crystal Structure of Polyphosphate kinase 2-II (PPK2-II) from Lysinibacillus fusiformis bound to TMP | | 分子名称: | PHOSPHATE ION, Polyphosphate kinase, THYMIDINE-5'-PHOSPHATE | | 著者 | Friedrich, F, Kuge, M, Keppler, M, Gerhardt, S, Einsle, O, Andexer, J.N. | | 登録日 | 2024-10-29 | | 公開日 | 2025-02-05 | | 最終更新日 | 2025-03-12 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Insights into Broad-Range Polyphosphate Kinase 2-II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis.
Chembiochem, 26, 2025
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9H8J
 | | Crystal Structure of Polyphosphate kinase 2-II (PPK2-II) from Lysinibacillus fusiformis in apo form | | 分子名称: | PHOSPHATE ION, Polyphosphate kinase, SUCCINIC ACID | | 著者 | Friedrich, F, Kuge, M, Keppler, M, Gerhardt, S, Einsle, O, Andexer, J.N. | | 登録日 | 2024-10-29 | | 公開日 | 2025-02-05 | | 最終更新日 | 2025-03-12 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Insights into Broad-Range Polyphosphate Kinase 2-II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis.
Chembiochem, 26, 2025
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9H8K
 | | Crystal Structure of Polyphosphate kinase 2-II (PPK2-II) from Lysinibacillus fusiformis bound to AMP | | 分子名称: | ADENOSINE MONOPHOSPHATE, CHLORIDE ION, PHOSPHATE ION, ... | | 著者 | Friedrich, F, Kuge, M, Keppler, M, Gerhardt, S, Einsle, O, Andexer, J.N. | | 登録日 | 2024-10-29 | | 公開日 | 2025-02-05 | | 最終更新日 | 2025-03-12 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Insights into Broad-Range Polyphosphate Kinase 2-II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis.
Chembiochem, 26, 2025
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2F87
 | | Solution structure of a GAAG tetraloop in SRP RNA from Pyrococcus furiosus | | 分子名称: | SRP RNA | | 著者 | Okada, K, Takahashi, M, Sakamoto, T, Nakamura, K, Kanai, A, Kawai, G | | 登録日 | 2005-12-02 | | 公開日 | 2006-08-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a GAAG tetraloop in helix 6 of SRP RNA from Pyrococcus furiosus
Nucleosides Nucleotides Nucleic Acids, 25, 2006
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7LUF
 | | HSV1 polymerase ternary complex with dsDNA and PNU-183792 | | 分子名称: | DNA (5'-D(*CP*GP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*TP*AP*C)-3'), DNA (5'-D(P*AP*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*CP*G)-3'), DNA polymerase, ... | | 著者 | Hayes, R.P, Klein, D. | | 登録日 | 2021-02-22 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.
Nat Commun, 12, 2021
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7XXY
 | | Macaca mulatta galectin-10/Charcot-Leyden crystal protein with lactose | | 分子名称: | Galectin-10/Charcot-Leyden crystal protein, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | | 著者 | Su, J.Y. | | 登録日 | 2022-05-31 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Glutathione disrupts galectin-10 Charcot-Leyden crystal formation to possibly ameliorate eosinophil-based diseases such as asthma.
Acta Biochim.Biophys.Sin., 55, 2023
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7XXX
 | | Macaca mulatta galectin-10/Charcot-Leyden crystal protein | | 分子名称: | Galectin-10/Charcot-Leyden crystal protein | | 著者 | Su, J.Y. | | 登録日 | 2022-05-31 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Glutathione disrupts galectin-10 Charcot-Leyden crystal formation to possibly ameliorate eosinophil-based diseases such as asthma.
Acta Biochim.Biophys.Sin., 55, 2023
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7XXZ
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7XXW
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7XXV
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2FZA
 | | Crystal structure of d(GCGGGAGC): the base-intercalated duplex | | 分子名称: | 5'-D(*GP*(CBR)P*GP*GP*GP*AP*GP*C)-3', CALCIUM ION, SODIUM ION | | 著者 | Kondo, J, Ciengshin, T, Juan, E.C.M, Mitomi, K, Takenaka, A. | | 登録日 | 2006-02-09 | | 公開日 | 2007-01-23 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Crystal structure of d(gcGXGAgc) with X=G: a mutation at X is possible to occur in a base-intercalated duplex for multiplex formation
Nucleosides Nucleotides Nucleic Acids, 25, 2006
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8UQE
 | | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 26-residue linker (RING not modeled in density) | | 分子名称: | E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E | | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | | 登録日 | 2023-10-23 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.562 Å) | | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
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8UQA
 | | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 12-residue linker | | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, SODIUM ION, ... | | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | | 登録日 | 2023-10-23 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
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8UQB
 | | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 1) | | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, ZINC ION | | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | | 登録日 | 2023-10-23 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.484 Å) | | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
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8UQ9
 | | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 4-residue linker | | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, GLYCEROL, ... | | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | | 登録日 | 2023-10-23 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
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8UQ8
 | | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 2-residue linker | | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, GLYCEROL, ... | | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | | 登録日 | 2023-10-23 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
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8UQD
 | | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (condition 2. RING not modeled in density) | | 分子名称: | E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E | | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | | 登録日 | 2023-10-23 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.893 Å) | | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
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8UQC
 | | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 2) | | 分子名称: | E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, ZINC ION | | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | | 登録日 | 2023-10-23 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
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7ZOB
 | | Metagenomic cytidine deaminase Cdd | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Metagenomic cytidine deaminase Cdd, SULFATE ION, ... | | 著者 | Tamulaitiene, G, Urbeliene, N, Meskys, R. | | 登録日 | 2022-04-25 | | 公開日 | 2023-02-01 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Cytidine deaminases catalyze the conversion of N ( S , O ) 4 -substituted pyrimidine nucleosides.
Sci Adv, 9, 2023
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7KID
 | | PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 72 | | 分子名称: | (1S,2R,3aR,4S,6aR)-4-[(2-amino-3,5-difluoroquinolin-7-yl)methyl]-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydropentalene-1,6a(1H)-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... | | 著者 | Palte, R.L. | | 登録日 | 2020-10-23 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.
J.Med.Chem., 64, 2021
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7KIC
 | | PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34 | | 分子名称: | (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... | | 著者 | Palte, R.L. | | 登録日 | 2020-10-23 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.
J.Med.Chem., 64, 2021
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