PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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4K9Y	FOCAL ADHESION KINASE Catalytic domain in complex with 1-[4-(6-Amino-purin-9-yl)-phenyl]-3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-urea 分子名称: 1-[4-(6-amino-9H-purin-9-yl)phenyl]-3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea, Focal adhesion kinase 1 著者 Musil, D, Graedler, U, Lehmann, M, Heinrich, T, Dresing, V. 登録日 2013-04-21 公開日 2013-09-11 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-based discovery of focal adhesion kinase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
7FPU	DHFR:NADP+:FOL complex at 290 K (crystal 4) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-10 公開日 2023-09-20 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
6WBR	Crystal structure of AceCas9 bound with guide RNA and DNA with 5'-NNNCC-3' PAM 分子名称: CRISPR-associated endonuclease, Csn1 family,CRISPR-associated endonuclease, Csn1 family, ... 著者 Li, H, Das, A. 登録日 2020-03-27 公開日 2020-11-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 The molecular basis for recognition of 5'-NNNCC-3' PAM and its methylation state by Acidothermus cellulolyticus Cas9. Nat Commun, 11, 2020
7FPV	DHFR:NADP+:FOL complex at 290 K (crystal 5) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-10 公開日 2023-09-20 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.04 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
6VJM	Human metabotropic GABA(B) receptor in its apo state 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Shaye, H, Han, G.W, Gati, C, Cherezov, V. 登録日 2020-01-16 公開日 2020-06-10 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (3.97 Å) 主引用文献 Structural basis of the activation of a metabotropic GABA receptor. Nature, 584, 2020
7FPY	DHFR:NADP+:FOL complex at 300 K (crystal 2) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-10 公開日 2023-09-20 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
7FQ8	DHFR:NADP+:FOL complex (crystal 1, pass 2, 310 K) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-12 公開日 2023-09-20 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.21 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
7FQE	DHFR:NADP+:FOL complex (crystal 2, pass 3, 295 K) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-12 公開日 2023-09-20 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
7FQG	DHFR:NADP+:FOL complex (crystal 2, pass 5, 295 K) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-12 公開日 2023-09-20 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
7FPZ	DHFR:NADP+:FOL complex at 300 K (crystal 3) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-10 公開日 2023-09-20 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
7FQ4	DHFR:NADP+:FOL complex at 310 K (crystal 2) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-12 公開日 2023-09-20 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
4RQ5	Human DNA Polymerase Beta With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine (8-oxoG)and dATP soaked with MgCl2 for 60 s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ACETATE ION, CHLORIDE ION, ... 著者 Vyas, R, Suo, Z. 登録日 2014-10-31 公開日 2015-04-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Viewing Human DNA Polymerase beta Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography. J.Am.Chem.Soc., 137, 2015
7FQ3	DHFR:NADP+:FOL complex at 310 K (crystal 1) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-12 公開日 2023-09-20 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
7FPP	DHFR:NADP+:FOL complex at 280 K (crystal 5) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-09 公開日 2023-09-20 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.03 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
7FQ0	DHFR:NADP+:FOL complex at 300 K (crystal 4) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-10 公開日 2023-09-20 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
7FPQ	DHFR:NADP+:FOL complex at 280 K (multi-crystal) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-09 公開日 2023-09-20 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.03 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
6D8L	Group I self-splicing intron P4-P6 domain mutant U131A (without isopropanol soaking) 分子名称: Group I self-splicing intron, MAGNESIUM ION 著者 Shoffner, G.M. 登録日 2018-04-26 公開日 2018-07-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.1402154 Å) 主引用文献 In Crystallo Selection to Establish New RNA Crystal Contacts. Structure, 26, 2018
6VM4	Chloroplast ATP synthase (C2, CF1FO) 分子名称: ATP synthase delta chain, chloroplastic, ATP synthase epsilon chain, ... 著者 Yang, J.-H, Williams, D, Kandiah, E, Fromme, P, Chiu, P.-L. 登録日 2020-01-27 公開日 2020-09-09 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (7.08 Å) 主引用文献 Structural basis of redox modulation on chloroplast ATP synthase. Commun Biol, 3, 2020
7FQ7	DHFR:NADP+:FOL complex (crystal 1, pass 1, 295 K) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-12 公開日 2023-09-20 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
7FQ9	DHFR:NADP+:FOL complex (crystal 1, pass 3, 295 K) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-12 公開日 2023-09-20 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.11 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
6DKF	Caseinolytic protease (ClpP) from Staphylococcus aureus mutant - V7A 分子名称: ATP-dependent Clp protease proteolytic subunit 著者 Ripstein, Z.A, Vahidi, S, Kay, L.E, Rubinstein, J.L. 登録日 2018-05-29 公開日 2018-06-27 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Reversible inhibition of the ClpP protease via an N-terminal conformational switch. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7FQB	DHFR:NADP+:FOL complex (crystal 1, pass 5, 295 K) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-12 公開日 2023-09-20 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.14 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
5BOT	X-RAY Co-structure of MMP-13 with ethyl 5-carbamoyl-1H-indole-2-carboxylate 分子名称: CALCIUM ION, Collagenase 3, ZINC ION, ... 著者 Farrow, N.A, Padyana, A.K. 登録日 2015-05-27 公開日 2015-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J. Med. Chem., 54, 2011
7FQC	DHFR:NADP+:FOL complex (crystal 2, pass 1, 295 K) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-12 公開日 2023-09-20 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
7FPT	DHFR:NADP+:FOL complex at 290 K (crystal 3) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-09-10 公開日 2023-09-20 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.07 Å) 主引用文献 Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024

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