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PDB: 236 件
7M7N
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BU of 7m7n by Molmil
Human DNA Pol eta with 2'-FA-ended primer and dAMPNPP
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*(AF5))-3'), DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Gregory, M.T, Gao, Y, Yang, W.
登録日2021-03-28
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Proc.Natl.Acad.Sci.USA, 118, 2021
5KFZ
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BU of 5kfz by Molmil
Human DNA polymerase eta-DNA ternary complex: reaction first with 1 mM Mn2+ for 1800s then with 5 mM Mn2+ for 60s at 14 degree
分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DIPHOSPHATE, ...
著者Gao, Y, Yang, W.
登録日2016-06-12
公開日2016-06-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Science, 352, 2016
5KFN
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BU of 5kfn by Molmil
Human DNA polymerase eta-DNA ternary complex with Sp-dATP-alpha-S: reaction with 1 mM Mg2+ for 1800s
分子名称: 2'-DEOXYADENOSINE 5'-O-(1-THIOTRIPHOSPHATE), CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Gao, Y, Yang, W.
登録日2016-06-12
公開日2016-06-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Science, 352, 2016
5KFS
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BU of 5kfs by Molmil
Human DNA polymerase eta R61A-DNA ternary complex: ground state at pH7.0 (K+ MES) with 1 Ca2+ ion
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Gao, Y, Yang, W.
登録日2016-06-12
公開日2016-06-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Science, 352, 2016
7M7T
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BU of 7m7t by Molmil
Human DNA Pol eta S113A with dT-ended primer and dATP: in crystallo reaction for 0 s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Gregory, M.T, Gao, Y, Yang, W.
登録日2021-03-28
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M7M
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BU of 7m7m by Molmil
Human DNA Pol eta with rA-ended primer and dAMPNPP
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ...
著者Gregory, M.T, Gao, Y, Yang, W.
登録日2021-03-28
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Proc.Natl.Acad.Sci.USA, 118, 2021
7U7L
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BU of 7u7l by Molmil
Human DNA polymerase eta-DNA ternary mismatch complex:reaction with 1.0 mM Mg2+ for 300s with flipped-out product
分子名称: DIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Chang, C, Gao, Y.
登録日2022-03-07
公開日2022-05-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Nat Commun, 13, 2022
7M84
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BU of 7m84 by Molmil
Human DNA Pol eta S113A with dA-ended primer and dATP: in crystallo reaction for 40 s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), ...
著者Gregory, M.T, Gao, Y, Yang, W.
登録日2021-03-29
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Proc.Natl.Acad.Sci.USA, 118, 2021
5KFC
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BU of 5kfc by Molmil
Human DNA polymerase eta-DNA ternary complex: reaction with 1 mM Mn2+ for 180s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Gao, Y, Yang, W.
登録日2016-06-12
公開日2016-06-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Science, 352, 2016
4ECQ
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BU of 4ecq by Molmil
Human DNA polymerase eta- DNA ternary complex: AT crystal at pH6.8(K+ MES) with 1 Ca2+ ion
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*A)-3'), ...
著者Nakamura, T, Zhao, Y, Yang, W.
登録日2012-03-26
公開日2012-07-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Watching DNA polymerase eta make a phosphodiester bond
Nature, 487, 2012
5KFA
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BU of 5kfa by Molmil
Human DNA polymerase eta-DNA ternary complex: ground state at pH7.0 (K+ MES) with 1 Ca2+ ion
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Gao, Y, Yang, W.
登録日2016-06-12
公開日2016-06-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Science, 352, 2016
5KFX
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BU of 5kfx by Molmil
Human DNA polymerase eta R61A-DNA ternary complex: reaction with 1 mM Mg2+ for 300s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
著者Gao, Y, Yang, W.
登録日2016-06-12
公開日2016-06-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Science, 352, 2016
5KFO
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BU of 5kfo by Molmil
Human DNA polymerase eta-DNA ternary complex with Sp-dATP-alpha-S: reaction with 1 mM Mn2+ for 1800s
分子名称: 2'-DEOXYADENOSINE 5'-O-(1-THIOTRIPHOSPHATE), CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Gao, Y, Yang, W.
登録日2016-06-12
公開日2016-06-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Science, 352, 2016
5KFT
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BU of 5kft by Molmil
Human DNA polymerase eta R61A-DNA ternary complex: reaction with 1 mM Mg2+ for 40s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Gao, Y, Yang, W.
登録日2016-06-12
公開日2016-06-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Science, 352, 2016
7U74
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BU of 7u74 by Molmil
Human DNA polymerase eta-DNA ternary mismatch complex:reaction with 0.5 mM Mn2+ for 1800s then with 10 mM Mn2+ for 30s
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Chang, C, Gao, Y.
登録日2022-03-07
公開日2022-05-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Nat Commun, 13, 2022
8V7G
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BU of 8v7g by Molmil
Human DNA polymerase eta-DNA-gemC-ended primer-dAMPNPP ternary complex with Mg2+
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*(U7B))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mn2+
To Be Published
4ECV
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BU of 4ecv by Molmil
Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 230 sec
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
著者Nakamura, T, Zhao, Y, Yang, W.
登録日2012-03-26
公開日2012-07-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.521 Å)
主引用文献Watching DNA polymerase eta make a phosphodiester bond
Nature, 487, 2012
4ED8
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BU of 4ed8 by Molmil
Human DNA polymerase eta - DNA ternary complex: Reaction in the TG crystal at pH 7.0, Normal translocation
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*G)-3'), ...
著者Nakamura, T, Zhao, Y, Yang, W.
登録日2012-03-27
公開日2012-07-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.521 Å)
主引用文献Watching DNA polymerase eta make a phosphodiester bond
Nature, 487, 2012
7U72
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BU of 7u72 by Molmil
Human DNA polymerase eta-DNA ternary mismatch complex:ground state at pH7.0 (K+ MES) with 1 Ca2+ ion
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Chang, C, Gao, Y.
登録日2022-03-07
公開日2022-05-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Nat Commun, 13, 2022
7U7U
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BU of 7u7u by Molmil
Human DNA polymerase eta-DNA-dGMPNPP ternary mismatch complex in 0.1 mM Mg2+ for 600s
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Chang, C, Gao, Y.
登録日2022-03-07
公開日2022-05-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Nat Commun, 13, 2022
4Q8E
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BU of 4q8e by Molmil
Human DNA polymerase eta inserting dCMPNPP opposite a phenanthriplatin adducted G
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, 5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3', 5'-D(*CP*AP*TP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3', ...
著者Gregory, M.T, Yang, W.
登録日2014-04-26
公開日2014-07-02
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.549 Å)
主引用文献Structural and mechanistic studies of polymerase eta bypass of phenanthriplatin DNA damage.
Proc.Natl.Acad.Sci.USA, 111, 2014
5KFE
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BU of 5kfe by Molmil
Human DNA polymerase eta-DNA ternary complex: reaction with 1 mM Mn2+ for 600s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Gao, Y, Yang, W.
登録日2016-06-12
公開日2016-06-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Science, 352, 2016
5KFG
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BU of 5kfg by Molmil
Human DNA polymerase eta-DNA ternary complex: reaction with 10 mM Mn2+ for 30s
分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, ...
著者Gao, Y, Yang, W.
登録日2016-06-12
公開日2016-06-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Science, 352, 2016
5KG6
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BU of 5kg6 by Molmil
Human DNA polymerase eta-DNA ternary complex: reaction first with 1 mM Mn2+ for 1800s then with 10 mM Ca2+ for 60s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*A)-3'), ...
著者Gao, Y, Yang, W.
登録日2016-06-12
公開日2016-06-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Science, 352, 2016
5KFU
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BU of 5kfu by Molmil
Human DNA polymerase eta R61A-DNA ternary complex: reaction with 1 mM Mg2+ for 80s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
著者Gao, Y, Yang, W.
登録日2016-06-12
公開日2016-06-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Science, 352, 2016

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件を2024-08-07に公開中

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