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PDB: 8 件

2V4U
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BU of 2v4u by Molmil
Human CTP synthetase 2 - glutaminase domain in complex with 5-OXO-L- NORLEUCINE
分子名称: CTP SYNTHASE 2
著者Welin, M, Moche, M, Andersson, J, Arrowsmith, C.H, Berglund, H, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Lehtio, L, Nilsson, M.E, Nyman, T, Olesen, K, Persson, C, Sagemark, J, Schueler, H, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wisniewska, M, Weigelt, J, Wikstrom, M, Nordlund, P.
登録日2008-09-29
公開日2008-10-07
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Human Ctp Synthetase 2 - Glutaminase Domain in Complex with 5-Oxo-L-Norleucine
To be Published
2VKT
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HUMAN CTP SYNTHETASE 2 - GLUTAMINASE DOMAIN
分子名称: CTP SYNTHASE 2
著者Welin, M, Tresaugues, L, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Herman, M.D, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Lehtio, L, Moche, M, Nilsson, M.E, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, van den Berg, S, Weigelt, J, Nordlund, P, Structural Genomics Consortium (SGC)
登録日2007-12-28
公開日2008-01-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Human Ctp Synthetase 2 - Glutaminase Domain
To be Published
7MII
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Human CTPS2 bound to inhibitor T35
分子名称: 2-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}-2-methyl-N-{5-[6-(trifluoromethyl)pyrazin-2-yl]pyridin-2-yl}propanamide, CTP synthase 2, GLUTAMINE, ...
著者Lynch, E.M, Dimattia, M.A, Kollman, J.M.
登録日2021-04-16
公開日2021-10-13
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MH1
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BU of 7mh1 by Molmil
Human CTPS2 bound to CTP
分子名称: CTP synthase 2, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
著者Lynch, E.M, Kollman, J.M.
登録日2021-04-14
公開日2021-10-13
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MIH
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BU of 7mih by Molmil
Human CTPS2 bound to inhibitor R80
分子名称: CTP synthase 2, GLUTAMINE, MAGNESIUM ION, ...
著者Lynch, E.M, Dimattia, M.A, Kollman, J.M.
登録日2021-04-16
公開日2021-10-13
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
3IHL
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BU of 3ihl by Molmil
Human CTPS2 crystal structure
分子名称: ADENOSINE-5'-DIPHOSPHATE, CTP synthase 2, PHOSPHATE ION
著者Moche, M, Siponen, M.I, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Kotzsch, A, Kragh Nielsen, T, Nyman, T, Persson, C, Roos, A.K, Sagemark, J, Schueler, H, Schutz, P, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Nordlund, P, Structural Genomics Consortium (SGC)
登録日2009-07-30
公開日2009-10-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Human CTPS2 crystal structure
To be Published
6PK7
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BU of 6pk7 by Molmil
cryoEM structure of the product-bound human CTP synthase 2 filament
分子名称: ADENOSINE-5'-DIPHOSPHATE, CTP synthase 2, CYTIDINE-5'-TRIPHOSPHATE
著者Lynch, E.M, Kollman, J.M.
登録日2019-06-28
公開日2019-12-25
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments.
Nat.Struct.Mol.Biol., 27, 2020
6PK4
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BU of 6pk4 by Molmil
cryoEM structure of the substrate-bound human CTP synthase 2 filament
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CTP synthase 2, URIDINE 5'-TRIPHOSPHATE
著者Lynch, E.M, Kollman, J.M.
登録日2019-06-28
公開日2019-12-25
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments.
Nat.Struct.Mol.Biol., 27, 2020

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件を2024-07-10に公開中

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