3BVX
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![BU of 3bvx by Molmil](/molmil-images/mine/3bvx) | |
3BVU
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![BU of 3bvu by Molmil](/molmil-images/mine/3bvu) | |
2OW6
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![BU of 2ow6 by Molmil](/molmil-images/mine/2ow6) | Golgi alpha-mannosidase II complex with (1r,5s,6s,7r,8s)-1-thioniabicyclo[4.3.0]nonan-5,7,8-triol chloride | 分子名称: | (1R,5S,6S,7R,8S)-1-THIONIABICYCLO[4.3.0]NONAN-5,7,8-TRIOL, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A. | 登録日 | 2007-02-15 | 公開日 | 2008-01-08 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | Binding of sulfonium-ion analogues of di-epi-swainsonine and 8-epi-lentiginosine to Drosophila Golgi alpha-mannosidase II: The role of water in inhibitor binding. Proteins, 71, 2008
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3DDF
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![BU of 3ddf by Molmil](/molmil-images/mine/3ddf) | GOLGI MANNOSIDASE II complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)-2-hydroxy-1 phenylethyl]amino}methyl) pyrrolidin-2-one | 分子名称: | (3R,4R,5R)-3,4-dihydroxy-5-({[(1R)-2-hydroxy-1-phenylethyl]amino}methyl)pyrrolidin-2-one, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ... | 著者 | Kuntz, D.A, Rose, D.R, Hoffman, D. | 登録日 | 2008-06-05 | 公開日 | 2008-07-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site Bioorg.Med.Chem., 16, 2008
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3BVW
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1TQW
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![BU of 1tqw by Molmil](/molmil-images/mine/1tqw) | Golgi alpha-Mannosidase II In Complex With A Diastereomer of Seleno-Salacinol | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIDEOXY-1,4-[[2R,3R)-2,4-DIHYDROXY-3-(SULFOXY)BUTYL]EPISELENONIUMYLIDENE]-D-ARABINITOL INNER SALT, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A, Ghavami, A, Johnston, B.D, Pinto, B.M, Rose, D.R. | 登録日 | 2004-06-18 | 公開日 | 2005-02-01 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Insights into the Mechanism of Drosophila melanogaster Golgi a-Mannosidase II Through Crystallographic Analysis of the Interactions with Analogues of the Naturally Occurring Glycomimetic Salacinol TETRAHEDRON ASYMMETRY, 16, 2005
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1QWN
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![BU of 1qwn by Molmil](/molmil-images/mine/1qwn) | GOLGI ALPHA-MANNOSIDASE II Covalent Intermediate Complex with 5-fluoro-gulosyl-fluoride | 分子名称: | (2R,3S,4R,5S)-2,6-difluoro-2-(hydroxymethyl)oxane-3,4,5-triol, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | Numao, S, Kuntz, D.A, Withers, S.G, Rose, D.R. | 登録日 | 2003-09-02 | 公開日 | 2003-10-07 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates. J.Biol.Chem., 278, 2003
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3DX1
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![BU of 3dx1 by Molmil](/molmil-images/mine/3dx1) | Golgi alpha-Mannosidase II in complex with Mannostatin analog (1S,2S,3R,4R)-4-aminocyclopentane-1,2,3-triol | 分子名称: | (1S,2S,3R,4R)-4-aminocyclopentane-1,2,3-triol, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A, Rose, D.R. | 登録日 | 2008-07-23 | 公開日 | 2009-07-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | 主引用文献 | The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A. Chembiochem, 10, 2009
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3BUI
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![BU of 3bui by Molmil](/molmil-images/mine/3bui) | Golgi mannosidase II D204A catalytic nucleophile mutant complex with Tris | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-mannosidase 2, ... | 著者 | Kuntz, D.A, Rose, D.R. | 登録日 | 2008-01-02 | 公開日 | 2008-07-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant. J.Am.Chem.Soc., 130, 2008
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3EJR
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![BU of 3ejr by Molmil](/molmil-images/mine/3ejr) | Golgi alpha-Mannosidase II in complex with 5-substitued swainsonine analog: (5R)-5-[2'-oxo-2'-(4-tert-butylphenyl)ethyl]-swainsonine | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1-(4-tert-butylphenyl)-2-[(1S,2R,5R,8R,8aR)-1,2,8-trihydroxyoctahydroindolizin-5-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A, Shea, K, Rose, D.R. | 登録日 | 2008-09-18 | 公開日 | 2009-10-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II. Chembiochem, 11, 2010
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2F7P
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![BU of 2f7p by Molmil](/molmil-images/mine/2f7p) | Golgi alpha-mannosidase II complex with benzyl-mannostatin A | 分子名称: | (1R,2R,3R,4S,5R)-4-(BENZYLAMINO)-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A, Rose, D.R. | 登録日 | 2005-12-01 | 公開日 | 2006-07-04 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Structural Basis of the Inhibition of Golgi alpha-Mannosidase II by Mannostatin A and the Role of the Thiomethyl Moiety in Ligand-Protein Interactions. J.Am.Chem.Soc., 128, 2006
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3BVV
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![BU of 3bvv by Molmil](/molmil-images/mine/3bvv) | Golgi mannosidase II D204A catalytic nucleophile mutant complex with METHYL ALPHA-D-MANNOPYRANOSYL-(1->3)-[6-THIO-ALPHA-D-MANNOPYRANOSYL-(1->6)]-BETA-D-MANNOPYRANOSIDE | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Alpha-mannosidase 2, ... | 著者 | Kuntz, D.A, Rose, D.R. | 登録日 | 2008-01-07 | 公開日 | 2008-07-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant. J.Am.Chem.Soc., 130, 2008
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1TQS
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![BU of 1tqs by Molmil](/molmil-images/mine/1tqs) | Golgi alpha-Mannosidase II In Complex With Salacinol | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIDEOXY-1,4-[[2S,3S)-2,4-DIHYDROXY-3-(SULFOXY)BUTYL]EPISULFONIUMYLIDENE]-D-ARABINITOL INNER SALT, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A, Ghavami, A, Johnston, B.D, Pinto, B.M, Rose, D.R. | 登録日 | 2004-06-18 | 公開日 | 2005-01-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues Tetrahedron Asymmetry, 16, 2005
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3BVT
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![BU of 3bvt by Molmil](/molmil-images/mine/3bvt) | GOLGI MANNOSIDASE II D204A catalytic nucleophile mutant complex with Methyl (alpha-D-mannopyranosyl)-(1->3)-S-alpha-D-mannopyranoside | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A, Rose, D.R. | 登録日 | 2008-01-07 | 公開日 | 2008-07-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant. J.Am.Chem.Soc., 130, 2008
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3BLB
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2F18
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![BU of 2f18 by Molmil](/molmil-images/mine/2f18) | GOLGI ALPHA-MANNOSIDASE II complex with (2R,3R,4S)-2-({[(1R)-2-hydroxy-1-phenylethyl]amino}methyl)pyrrolidine-3,4-diol | 分子名称: | (2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)PYRROLIDINE-3,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A, Rose, D.R. | 登録日 | 2005-11-14 | 公開日 | 2006-12-05 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography. Proteins, 69, 2007
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3CZS
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![BU of 3czs by Molmil](/molmil-images/mine/3czs) | Golgi alpha-mannosidase II (D204A nucleophile mutant) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-mannosidase 2, ... | 著者 | Shah, N, Rose, D.R. | 登録日 | 2008-04-29 | 公開日 | 2008-06-24 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Golgi alpha-mannosidase II cleaves two sugars sequentially in the same catalytic site. Proc.Natl.Acad.Sci.Usa, 105, 2008
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1QX1
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![BU of 1qx1 by Molmil](/molmil-images/mine/1qx1) | Golgi alpha-mannosidase II D341N mutant complex with 2-F-mannosyl-F | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-2-fluoro-beta-D-mannopyranosyl fluoride, ... | 著者 | Numao, S, Kuntz, D.A, Withers, S.G, Rose, D.R. | 登録日 | 2003-09-04 | 公開日 | 2003-10-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates. J.Biol.Chem., 278, 2003
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3EJU
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![BU of 3eju by Molmil](/molmil-images/mine/3eju) | Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog:(5S)-5-[2'-oxo-2'-(4-tert-butylphenyl)ethyl]-swainsonine | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1-(4-tert-butylphenyl)-2-[(1S,2R,5S,8R,8aR)-1,2,8-trihydroxyoctahydroindolizin-5-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A, Shea, K, Rose, D.R. | 登録日 | 2008-09-18 | 公開日 | 2009-10-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II. Chembiochem, 11, 2010
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3EJP
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![BU of 3ejp by Molmil](/molmil-images/mine/3ejp) | Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5R)-5-[2'-oxo-2'-(phenyl)ethyl]-swainsonine | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1-phenyl-2-[(1S,2R,5R,8R,8aR)-1,2,8-trihydroxyoctahydroindolizin-5-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A, Rose, D.R. | 登録日 | 2008-09-18 | 公開日 | 2009-10-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II. Chembiochem, 11, 2010
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3EJT
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![BU of 3ejt by Molmil](/molmil-images/mine/3ejt) | Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog:(5R)-5-[2'-(4-tert-butylphenyl)ethyl]-swainsonine | 分子名称: | (1S,2R,5R,8R,8aR)-5-[2-(4-tert-butylphenyl)ethyl]octahydroindolizine-1,2,8-triol, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A, Shea, K, Rose, D.R. | 登録日 | 2008-09-18 | 公開日 | 2009-10-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II. Chembiochem, 11, 2010
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3EJS
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![BU of 3ejs by Molmil](/molmil-images/mine/3ejs) | Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5S)-5-[2'-(4-tert-butylphenyl)ethyl]-swainsonine | 分子名称: | (1S,2R,5S,8R,8aR)-5-[2-(4-tert-butylphenyl)ethyl]octahydroindolizine-1,2,8-triol, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A, Shea, K, Rose, D.R. | 登録日 | 2008-09-18 | 公開日 | 2009-10-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II. Chembiochem, 11, 2010
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2F7R
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![BU of 2f7r by Molmil](/molmil-images/mine/2f7r) | Golgi alpha-mannosidase II complex with benzyl-aminocyclopentitetrol | 分子名称: | (1R,2R,3S,4S,5R)-5-(BENZYLAMINO)CYCLOPENTANE-1,2,3,4-TETROL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A, Rose, D.R. | 登録日 | 2005-12-01 | 公開日 | 2006-12-12 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Golgi alpha-mannosidase II complex with benzyl-aminocyclopentitetrol To be Published
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3DX4
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![BU of 3dx4 by Molmil](/molmil-images/mine/3dx4) | Golgi alpha-Mannosidase II in complex with Mannostatin analog (1R,2R,3R,4S,5R)-4-amino-5-methoxycyclopentane-1,2,3-triol | 分子名称: | (1R,2R,3R,4S,5R)-4-amino-5-methoxycyclopentane-1,2,3-triol, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kuntz, D.A, Rose, D.R. | 登録日 | 2008-07-23 | 公開日 | 2009-07-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A. Chembiochem, 10, 2009
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3BUB
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![BU of 3bub by Molmil](/molmil-images/mine/3bub) | Golgi alpha-mannosidase II with an empty active site | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-mannosidase 2, ... | 著者 | Kuntz, D.A, Rose, D.R. | 登録日 | 2008-01-02 | 公開日 | 2008-07-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant. J.Am.Chem.Soc., 130, 2008
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