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PDB: 14 件
2AHX
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Crystal structure of ErbB4/HER4 extracellular domain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor tyrosine-protein kinase erbB-4, SULFATE ION, ...
著者Bouyain, S, Longo, P.A, Li, S, Ferguson, K.M, Leahy, D.J.
登録日2005-07-28
公開日2005-09-27
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.396 Å)
主引用文献The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand
Proc.Natl.Acad.Sci.USA, 102, 2005
2R4B
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BU of 2r4b by Molmil
ErbB4 kinase domain complexed with a thienopyrimidine inhibitor
分子名称: N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine, Receptor tyrosine-protein kinase erbB-4
著者Shewchuk, L.M, Uehling, D.E.
登録日2007-08-31
公開日2008-03-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3BCE
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BU of 3bce by Molmil
Crystal structure of the ErbB4 kinase
分子名称: DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, Receptor tyrosine-protein kinase erbB-4, ...
著者Qiu, C.
登録日2007-11-12
公開日2008-02-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase.
Structure, 16, 2008
3U2P
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Crystal structure of N-terminal three extracellular domains of ErbB4/Her4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor tyrosine-protein kinase erbB-4
著者Liu, P, Bouyain, S, Elgenbrot, C, Leahy, D.J.
登録日2011-10-04
公開日2011-11-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether.
Protein Sci., 21, 2012
3BBT
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BU of 3bbt by Molmil
crystal structure of the ErbB4 kinase in complex with lapatinib
分子名称: N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE, Receptor tyrosine-protein kinase erbB-4
著者Qiu, C.
登録日2007-11-11
公開日2008-02-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase.
Structure, 16, 2008
3U7U
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Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Neuregulin 1, Receptor tyrosine-protein kinase erbB-4
著者Liu, P, Cleveland IV, T.E, Bouyain, S, Longo, P.A, Leahy, D.J.
登録日2011-10-14
公開日2012-08-29
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献A single ligand is sufficient to activate EGFR dimers.
Proc.Natl.Acad.Sci.USA, 109, 2012
8U4L
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BU of 8u4l by Molmil
Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ...
著者Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N.
登録日2023-09-10
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (3.31 Å)
主引用文献Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain
To Be Published
8U4I
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Structure of the HER4/NRG1b Homodimer Extracellular Domain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ...
著者Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N.
登録日2023-09-10
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain
To Be Published
3U9U
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Crystal Structure of Extracellular Domain of Human ErbB4/Her4 in complex with the Fab fragment of mAb1479
分子名称: Fab Heavy Chain, Fab Light Chain, Receptor tyrosine-protein kinase erbB-4
著者Hollmen, M, Liu, P, Wildiers, H, Reinvall, I, Vandorpe, T, Smeets, A, Deraedt, K, Vahlberg, T, Joensuu, H, Leahy, D.J, Schoffski, P, Elenius, K.
登録日2011-10-19
公開日2012-10-31
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.42 Å)
主引用文献Proteolytic processing of ErbB4 in breast cancer.
Plos One, 7, 2012
8U4J
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Structure of the HER4/BTC Homodimer Extracellular Domain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Betacellulin, ...
著者Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N.
登録日2023-09-10
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structure of the HER4/BTC Homodimer Extracellular Domain
To Be Published
3BBW
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BU of 3bbw by Molmil
crystal structure of the ErbB4 kinase in its inactive conformation
分子名称: Receptor tyrosine-protein kinase erbB-4
著者Qiu, C.
登録日2007-11-11
公開日2008-02-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase.
Structure, 16, 2008
8U4K
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BU of 8u4k by Molmil
Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Betacellulin, ...
著者Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N.
登録日2023-09-10
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (4.27 Å)
主引用文献Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain
To Be Published
2LCX
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BU of 2lcx by Molmil
Spatial Structure of the ErbB4 dimeric TM domain
分子名称: Receptor tyrosine-protein kinase erbB-4
著者Mineev, K.S, Bocharov, E.V, Arseniev, A.S.
登録日2011-05-11
公開日2012-05-16
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural and thermodynamic insight into the process of "weak" dimerization of the ErbB4 transmembrane domain by solution NMR.
Biochim.Biophys.Acta, 1818, 2012
2L2T
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Solution NMR structure of the ErbB4 dimeric membrane domain
分子名称: Receptor tyrosine-protein kinase erbB-4
著者Mineev, K.S, Bocharov, E.V, Goncharuk, M.V, Arseniev, A.S.
登録日2010-08-27
公開日2011-09-14
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural and thermodynamic insight into the process of "weak" dimerization of the ErbB4 transmembrane domain by solution NMR.
Biochim. Biophys. Acta, 1818, 2012

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