1J2G
 
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4XFP
 | | Crystal Structure of Highly Active Mutant of Bacillus sp. TB-90 Urate Oxidase | | 分子名称: | 8-AZAXANTHINE, CHLORIDE ION, SULFATE ION, ... | | 著者 | Hibi, T, Hayashi, Y, Kawamura, A, Itoh, T. | | 登録日 | 2014-12-28 | | 公開日 | 2016-01-13 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Glycine Substitution of Surface Proline 287 Involves Entropic Enhancement of Bacillus sp. TB-90 Uricase Activity
To be published
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6A4M
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5FRC
 | | Structure of urate oxidase prepared by the 'soak-and-freeze' method under 42 bar of oxygen pressure | | 分子名称: | 8-AZAXANTHINE, OXYGEN MOLECULE, SODIUM ION, ... | | 著者 | Lafumat, B, Mueller-Dieckmann, C, Colloc'h, N, Prange, T, Royant, A, van der Linden, P, Carpentier, P. | | 登録日 | 2015-12-16 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.443 Å) | | 主引用文献 | Gas-Sensitive Biological Crystals Processed in Pressurized Oxygen and Krypton Atmospheres: Deciphering Gas Channels in Proteins Using a Novel `Soak-and-Freeze' Methodology.
J.Appl.Crystallogr., 49, 2016
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2PES
 | | Urate Oxidase in complex with tris-dipicolinate Lutetium | | 分子名称: | 8-AZAXANTHINE, LUTETIUM (III) ION, PYRIDINE-2,6-DICARBOXYLIC ACID, ... | | 著者 | Pompidor, G, Vicat, J, Kahn, R. | | 登録日 | 2007-04-03 | | 公開日 | 2008-04-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | A dipicolinate lanthanide complex for solving protein structures using anomalous diffraction.
Acta Crystallogr.,Sect.D, 66, 2010
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7A0L
 | | Joint neutron/X-ray room temperature structure of perdeuterated Aspergillus flavus urate oxidase in complex with the 8-azaxanthine inhibitor and catalytic water bound in the peroxo hole | | 分子名称: | 8-AZAXANTHINE, SODIUM ION, Uricase | | 著者 | McGregor, L, Bui, S, Blakeley, M.P, Steiner, R.A. | | 登録日 | 2020-08-09 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-05-01 | | 実験手法 | NEUTRON DIFFRACTION (1.33 Å), X-RAY DIFFRACTION | | 主引用文献 | Joint neutron/X-ray crystal structure of a mechanistically relevant complex of perdeuterated urate oxidase and simulations provide insight into the hydration step of catalysis.
Iucrj, 8, 2021
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6OE8
 | | The crystal structure of hyper-thermostable AgUricase mutant K12C/E286C | | 分子名称: | MALONATE ION, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ... | | 著者 | Shi, Y, Wang, T, Zhou, X.E, Liu, Q, Jiang, Y, Xu, H.E. | | 登録日 | 2019-03-27 | | 公開日 | 2019-08-21 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy.
Acta Pharmacol.Sin., 40, 2019
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5AYJ
 | | Hyperthermostable mutant of Bacillus sp. TB-90 Urate Oxidase - R298C | | 分子名称: | 9-METHYL URIC ACID, HEXAETHYLENE GLYCOL, SULFATE ION, ... | | 著者 | Hibi, T, Kume, A, Kawamura, A, Itoh, T, Nishiya, Y. | | 登録日 | 2015-08-21 | | 公開日 | 2016-01-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Hyperstabilization of Tetrameric Bacillus sp. TB-90 Urate Oxidase by Introducing Disulfide Bonds through Structural Plasticity
Biochemistry, 55, 2016
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1R4S
 | | URATE OXIDASE FROM ASPERGILLUS FLAVUS COMPLEXED WITH ITS INHIBITOR 9-METHYL URIC ACID | | 分子名称: | 9-METHYL URIC ACID, CYSTEINE, Uricase | | 著者 | Retailleau, P, Colloc'h, N, Prange, T. | | 登録日 | 2003-10-08 | | 公開日 | 2004-03-02 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Complexed and ligand-free high-resolution structures of urate oxidase (Uox) from Aspergillus flavus: a reassignment of the active-site binding mode.
Acta Crystallogr.,Sect.D, 60, 2004
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4FSK
 | | Urate oxidase-azide complex in anaerobic conditions | | 分子名称: | AZIDE ION, SODIUM ION, Uricase | | 著者 | Gabison, L, Colloc'h, N, El Hajji, M, Castro, B, Chiadmi, M, Prange, T. | | 登録日 | 2012-06-27 | | 公開日 | 2013-07-03 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Azide and Cyanide Have Different Inhibition Modes of Urate Oxidase
To be Published
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3WLV
 | | Thermostable urate oxidase from Bacillus sp. TB-90 | | 分子名称: | 8-AZAXANTHINE, CHLORIDE ION, POTASSIUM ION, ... | | 著者 | Hibi, T, Hayashi, Y, Itoh, T. | | 登録日 | 2013-11-14 | | 公開日 | 2014-06-18 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.747 Å) | | 主引用文献 | Intersubunit salt bridges with a sulfate anion control subunit dissociation and thermal stabilization of Bacillus sp. TB-90 urate oxidase.
Biochemistry, 53, 2014
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2FUB
 | | Crystal structure of urate oxidase at 140 MPa | | 分子名称: | 8-AZAXANTHINE, CYSTEINE, Uricase | | 著者 | Colloc'h, N, Girard, E, Fourme, R. | | 登録日 | 2006-01-26 | | 公開日 | 2006-02-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | High pressure macromolecular crystallography: The 140-MPa crystal structure at 2.3 A resolution of urate oxidase, a 135-kDa tetrameric assembly
Biochim.Biophys.Acta, 1764, 2006
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6RGM
 | | urate oxidase under 130 bar of krypton | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 8-AZAXANTHINE, ACETATE ION, ... | | 著者 | Prange, T, Colloc'h, N, Carpentier, P. | | 登録日 | 2019-04-17 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Comparative study of the effects of high hydrostatic pressure per se and high argon pressure on urate oxidase ligand stabilization
Acta Cryst. D, 78, 2022
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5M98
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7F2V
 | | Urate oxidase from Thermobispora bispora in apo form | | 分子名称: | DIMETHYL SULFOXIDE, SULFATE ION, Uricase | | 著者 | Chiu, Y.C, Hsu, T.S, Huang, C.Y, Hsu, C.H. | | 登録日 | 2021-06-14 | | 公開日 | 2022-05-04 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural and biochemical insights into a hyperthermostable urate oxidase from Thermobispora bispora for hyperuricemia and gout therapy.
Int.J.Biol.Macromol., 188, 2021
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7F2W
 | | TbUox in complex with uric acid | | 分子名称: | URIC ACID, Uricase | | 著者 | Chiu, Y.C, Hsu, T.S, Huang, C.Y, Hsu, C.H. | | 登録日 | 2021-06-14 | | 公開日 | 2022-05-04 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Structural and biochemical insights into a hyperthermostable urate oxidase from Thermobispora bispora for hyperuricemia and gout therapy.
Int.J.Biol.Macromol., 188, 2021
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6RGT
 | | Crystal structure of the cofactor-free Aspergillus flavus urate oxidase T57A variant anaerobically complexed with 9-methyl uric acid | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 9-METHYL URIC ACID, ... | | 著者 | Bui, S, Lowden, S.R.J, Steiner, R.A. | | 登録日 | 2019-04-17 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal structure of the cofactor-free Aspergillus flavus urate oxidase T57A variant anaerobically complexed with 9-methyl uric acid
To Be Published
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5LL1
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1R4U
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1R56
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1R51
 | | URATE OXIDASE FROM ASPERGILLUS FLAVUS COMPLEXED WITH ITS INHIBITOR 8-AZAXANTHIN | | 分子名称: | 8-AZAXANTHINE, CYSTEINE, Uricase | | 著者 | Prange, T, Retailleau, P, Colloc'h, N. | | 登録日 | 2003-10-09 | | 公開日 | 2004-03-02 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Complexed and ligand-free high-resolution structures of urate oxidase (Uox) from Aspergillus flavus: a reassignment of the active-site binding mode.
Acta Crystallogr.,Sect.D, 60, 2004
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3F2M
 | | Urate oxidase complexed with 8-azaxanthine at 150 MPa | | 分子名称: | 8-AZAXANTHINE, SODIUM ION, Uricase | | 著者 | Colloc'h, N, Girard, E, Kahn, R, Fourme, R. | | 登録日 | 2008-10-30 | | 公開日 | 2009-11-10 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure-function perturbation and dissociation of tetrameric urate oxidase by high hydrostatic pressure.
Biophys.J., 98, 2010
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3CKS
 | | Urate oxidase complexed with 8-azaxanthine under 4.0 MPa oxygen pressure | | 分子名称: | 8-AZAXANTHINE, OXYGEN MOLECULE, SODIUM ION, ... | | 著者 | Colloc'h, N, Gabison, L, Chiadmi, M, Abraini, J.H, Prange, T. | | 登録日 | 2008-03-17 | | 公開日 | 2008-10-07 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Oxygen pressurized X-ray crystallography: probing the dioxygen binding site in cofactorless urate oxidase and implications for its catalytic mechanism.
Biophys.J., 95, 2008
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7P0D
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7P0G
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