7RIT
| Drug-free A. baumannii MsbA | 分子名称: | ATP-dependent lipid A-core flippase | 著者 | Thelot, F, Liao, M. | 登録日 | 2021-07-20 | 公開日 | 2021-10-06 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | Distinct allosteric mechanisms of first-generation MsbA inhibitors. Science, 374, 2021
|
|
7T55
| |
7SEL
| E. coli MsbA in complex with LPS and inhibitor G7090 (compound 3) | 分子名称: | (2E)-3-{7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1-methylnaphthalen-2-yl}prop-2-enoic acid, (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, ATP-dependent lipid A-core flippase | 著者 | Payandeh, J, Koth, C.M, Verma, V.A. | 登録日 | 2021-09-30 | 公開日 | 2022-03-09 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.978 Å) | 主引用文献 | Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity. J.Med.Chem., 65, 2022
|
|
7S5X
| Human KATP channel in open conformation, focused on Kir and one SUR, position 1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7S5V
| |
7S5Y
| Human KATP channel in open conformation, focused on Kir and one SUR, position 2 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7S61
| Human KATP channel in open conformation, focused on Kir and one SUR, position 5 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7S60
| Human KATP channel in open conformation, focused on Kir and one SUR, position 4 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7S5Z
| Human KATP channel in open conformation, focused on Kir and one SUR, position 3 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2021-09-12 | 公開日 | 2021-12-01 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
4M2T
| Corrected Structure of Mouse P-glycoprotein bound to QZ59-SSS | 分子名称: | (4S,11S,18S)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, Multidrug resistance protein 1A | 著者 | Li, J, Jaimes, K.F, Aller, S.G. | 登録日 | 2013-08-05 | 公開日 | 2013-11-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (4.35 Å) | 主引用文献 | Refined structures of mouse P-glycoprotein. Protein Sci., 23, 2014
|
|
4MRN
| Structure of a bacterial Atm1-family ABC transporter | 分子名称: | ABC transporter related protein, LAURYL DIMETHYLAMINE-N-OXIDE, PHOSPHATE ION | 著者 | Lee, J.Y, Yang, J.G, Zhitnitsky, D, Lewinson, O, Rees, D.C. | 登録日 | 2013-09-17 | 公開日 | 2014-03-19 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for heavy metal detoxification by an Atm1-type ABC exporter. Science, 343, 2014
|
|
4MRS
| Structure of a bacterial Atm1-family ABC transporter | 分子名称: | ABC transporter related protein, LAURYL DIMETHYLAMINE-N-OXIDE, OXIDIZED GLUTATHIONE DISULFIDE, ... | 著者 | Lee, J.Y, Yang, J.G, Zhitnitsky, D, Lewinson, O, Rees, D.C. | 登録日 | 2013-09-17 | 公開日 | 2014-03-19 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural basis for heavy metal detoxification by an Atm1-type ABC exporter. Science, 343, 2014
|
|
8WP0
| Structure of the Arabidopsis E529Q/E1174Q ABCB19 in the ATP bound state | 分子名称: | ABC transporter B family member 19, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | 著者 | Ying, W, Wei, H, Liu, X, Sun, L. | 登録日 | 2023-10-08 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Science, 383, 2024
|
|
8WOM
| Structure of the wild-type Arabidopsis ABCB19 in the brassinolide-bound state | 分子名称: | ABC transporter B family member 19, Brassinolide | 著者 | Ying, W, Wei, H, Liu, X, Sun, L. | 登録日 | 2023-10-07 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Science, 383, 2024
|
|
8WOI
| |
8WOO
| Structure of the wild-type Arabidopsis ABCB19 in the brassinolide and AMP-PNP bound state | 分子名称: | ABC transporter B family member 19, Brassinolide, MAGNESIUM ION, ... | 著者 | Ying, W, Wei, H, Liu, X, Sun, L. | 登録日 | 2023-10-07 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Science, 383, 2024
|
|
8VSI
| Mechanistic Insights Revealed by YbtPQ in the Occluded State | 分子名称: | ABC transporter ATP-binding protein, ADP ORTHOVANADATE, MAGNESIUM ION, ... | 著者 | Hu, W, Parkinson, C, Zheng, H. | 登録日 | 2024-01-24 | 公開日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Mechanistic Insights Revealed by YbtPQ in the Occluded State. Biomolecules, 14, 2024
|
|
8WI2
| RD-hMRP5-inward open | 分子名称: | ATP-binding cassette sub-family C member 5, CYS-GLN-ASP-ALA-LEU-GLU-THR-ALA-ALA-ARG-ALA-GLU-GLY-LEU-SER-LEU-ASP-ALA-SER | 著者 | Liu, Z.M, Huang, Y. | 登録日 | 2023-09-24 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4.06 Å) | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
|
|
8WI3
| ND-hMRP5-inward open | 分子名称: | ATP-binding cassette sub-family C member 5 | 著者 | Liu, Z.M, Huang, Y. | 登録日 | 2023-09-24 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
|
|
8WI0
| wt-hMRP5 inward-open | 分子名称: | ATP-binding cassette sub-family C member 5 | 著者 | Liu, Z.M, Huang, Y. | 登録日 | 2023-09-24 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
|
|
8WI5
| M5PI-bound hMRP5 | 分子名称: | ATP-binding cassette sub-family C member 5 | 著者 | Liu, Z.M, Huang, Y. | 登録日 | 2023-09-24 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
|
|
8WI4
| m6-hMRP5 inward open | 分子名称: | ATP-binding cassette sub-family C member 5 | 著者 | Liu, Z.M, Huang, Y. | 登録日 | 2023-09-24 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
|
|
4MRV
| Structure of a bacterial Atm1-family ABC transporter | 分子名称: | ABC transporter related protein, LAURYL DIMETHYLAMINE-N-OXIDE, PHOSPHATE ION, ... | 著者 | Lee, J.Y, Yang, J.G, Zhitnitsky, D, Lewinson, O, Rees, D.C. | 登録日 | 2013-09-17 | 公開日 | 2014-03-19 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for heavy metal detoxification by an Atm1-type ABC exporter. Science, 343, 2014
|
|
4MRP
| Structure of a bacterial Atm1-family ABC transporter | 分子名称: | ABC transporter related protein, GLUTATHIONE, LAURYL DIMETHYLAMINE-N-OXIDE, ... | 著者 | Lee, J.Y, Yang, J.G, Zhitnitsky, D, Lewinson, O, Rees, D.C. | 登録日 | 2013-09-17 | 公開日 | 2014-03-19 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for heavy metal detoxification by an Atm1-type ABC exporter. Science, 343, 2014
|
|
8Y6H
| P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent | 分子名称: | ATP-dependent translocase ABCB1,mNeonGreen, UIC2 Fab heavy chain, UIC2 Fab light chain, ... | 著者 | Hamaguchi-Suzuki, N, Adachi, N, Moriya, T, Kawasaki, M, Suzuki, K, Anzai, N, Senda, T, Murata, T. | 登録日 | 2024-02-02 | 公開日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | 主引用文献 | Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules. Biochem.Biophys.Res.Commun., 709, 2024
|
|