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PDB: 659 件

8AAK
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Crystal structure of the PDZ tandem of syntenin in complex with compound 29
分子名称: (2~{S})-2-[[(2~{S})-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)-3-phenyl-propanoyl]amino]propanoic acid, GLYCEROL, Syntenin-1
著者Feracci, M, Barral, K.
登録日2022-07-01
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.554 Å)
主引用文献Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
8AAP
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Crystal structure of the PDZ tandem of syntenin in complex with compound SYNTi
分子名称: (2S)-2-[[(2S)-2-(6-bromanyl-3-oxidanylidene-1H-isoindol-2-yl)-3-[4-(5-ethanoyl-2-fluoranyl-phenyl)phenyl]propanoyl]amino]propanoic acid, Syntenin-1
著者Feracci, M, Barral, K.
登録日2022-07-01
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.174 Å)
主引用文献Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
8AAO
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Crystal structure of the PDZ tandem of syntenin in complex with compound 95
分子名称: (2~{S})-2-[[(2~{S})-3-[4-(5-ethanoyl-2-fluoranyl-phenyl)phenyl]-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanoyl]amino]propanoic acid, Syntenin-1
著者Feracci, M, Barral, K.
登録日2022-07-01
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.469 Å)
主引用文献Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
8AAI
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Crystal structure of the PDZ tandem of syntenin in complex with fragment E5
分子名称: (2~{S})-2-[[(2~{S})-3-methyl-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)butanoyl]amino]propanoic acid, Syntenin-1
著者Feracci, M, Barral, K.
登録日2022-07-01
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
1GQ4
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STRUCTURAL DETERMINANTS OF THE NHERF INTERACTION WITH BETA2AR AND PDGFR
分子名称: CHLORIDE ION, EZRIN-RADIXIN-MOESIN BINDING PHOSPHOPROTEIN-50
著者Karthikeyan, S, Leung, T, Ladias, J.A.A.
登録日2001-11-19
公開日2002-05-21
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Determinants of the Na+/H+ Exchanger Regulatory Factor Interaction with the Beta 2 Adrenergic and Platelet-Derived Growth Factor Receptors
J.Biol.Chem., 277, 2002
5VWK
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Crystal structure of human Scribble PDZ1:Beta-PIX complex
分子名称: Beta-PIX, Protein scribble homolog, SULFATE ION
著者Lim, K.Y.B, Kvansakul, M.
登録日2017-05-22
公開日2017-11-08
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor beta-PIX.
J. Biol. Chem., 292, 2017
5VWI
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Crystal structure of human Scribble PDZ1:Beta-PIX complex
分子名称: Protein scribble homolog, beta-PIX
著者Lim, K.Y.B, Kvansakul, M.
登録日2017-05-22
公開日2017-11-08
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor beta-PIX.
J. Biol. Chem., 292, 2017
1GQ5
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Structural Determinants of the NHERF Interaction with beta2-AR and PDGFR
分子名称: CHLORIDE ION, EZRIN-RADIXIN-MOESIN BINDING PHOSPHOPROTEIN-50
著者Karthikeyan, S, Leung, T, Ladias, J.A.A.
登録日2001-11-20
公開日2002-11-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Determinants of the Na+/H+ Exchanger Regulatory Factor Interaction with the Beta 2 Adrenergic and Platelet-Derived Growth Factor Receptors
J.Biol.Chem., 277, 2002
1I16
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STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES
分子名称: INTERLEUKIN 16
著者Muehlhahn, P, Zweckstetter, M, Georgescu, J, Ciosto, C, Renner, C, Lanzendoerfer, M, Lang, K, Ambrosius, D, Baier, M, Kurth, R, Holak, T.A.
登録日1998-05-20
公開日1999-05-25
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site.
Nat.Struct.Biol., 5, 1998
4G69
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Structure of the Human Discs Large 1 PDZ2 - Adenomatous Polyposis Coli Cytoskeletal Polarity Complex
分子名称: Adenomatous polyposis coli protein, Disks large homolog 1
著者Slep, K.C.
登録日2012-07-18
公開日2012-12-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the Human Discs Large 1 PDZ2- Adenomatous Polyposis Coli Cytoskeletal Polarity Complex: Insight into Peptide Engagement and PDZ Clustering.
Plos One, 7, 2012
1I92
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STRUCTURAL BASIS OF THE NHERF PDZ1-CFTR INTERACTION
分子名称: CHLORIDE ION, NA+/H+ EXCHANGE REGULATORY CO-FACTOR
著者Karthikeyan, S, Leung, T, Ladias, J.A.A.
登録日2001-03-16
公開日2001-06-27
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis of the Na+/H+ exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator.
J.Biol.Chem., 276, 2001
4E35
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Crystal structure of CFTR Associated Ligand (CAL) PDZ domain bound to iCAL36-L (ANSRWPTSIL) peptide
分子名称: GLYCEROL, Golgi-associated PDZ and coiled-coil motif-containing protein, iCAL50 peptide
著者Amacher, J.F, Madden, D.R.
登録日2012-03-09
公開日2012-12-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Stereochemical Determinants of C-terminal Specificity in PDZ Peptide-binding Domains: A NOVEL CONTRIBUTION OF THE CARBOXYLATE-BINDING LOOP.
J.Biol.Chem., 288, 2013
5WOU
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Crystal Structure of drosophila melanogaster Scribble PDZ1 domain in complex with Guk-Holder
分子名称: 1,2-ETHANEDIOL, GUK-holder, isoform A, ...
著者Caria, S, Kvansakul, M.
登録日2017-08-03
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Drosophila melanogasterGuk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large.
J. Biol. Chem., 293, 2018
4F8K
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Molecular analysis of the interaction between the prostacyclin receptor and the first PDZ domain of PDZK1
分子名称: Na(+)/H(+) exchange regulatory cofactor NHE-RF3, Prostacyclin receptor
著者Kocher, O, Birrane, G, Kinsella, B.T, Mulvaney, E.P.
登録日2012-05-17
公開日2013-02-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Molecular Analysis of the Prostacyclin Receptor's Interaction with the PDZ1 Domain of Its Adaptor Protein PDZK1.
Plos One, 8, 2013
4H11
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Interaction partners of PSD-93 studied by X-ray crystallography and fluorescent polarization spectroscopy
分子名称: ACETATE ION, Disks large homolog 2, SULFATE ION
著者Fiorentini, M, Kastrup, J.S, Gajhede, M.
登録日2012-09-10
公開日2013-04-03
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy.
Acta Crystallogr.,Sect.D, 69, 2013
1IU2
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The first PDZ domain of PSD-95
分子名称: PSD-95
著者Long, J.-F, Tochio, H, Wang, P, Sala, C, Niethammer, M, Sheng, M, Zhang, M.
登録日2002-02-19
公開日2003-03-11
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95
J.MOL.BIOL., 327, 2003
4GVD
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BU of 4gvd by Molmil
Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in complex with Syndecan1 Peptide
分子名称: 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID), CHLORIDE ION, SODIUM ION, ...
著者Liu, X, Shepherd, T.R, Murray, A.M, Xu, Z, Fuentes, E.J.
登録日2012-08-30
公開日2013-03-13
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics.
Structure, 21, 2013
1IHJ
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Crystal Structure of the N-terminal PDZ domain of InaD in complex with a NorpA C-terminal peptide
分子名称: InaD, phospholipase C
著者Kimple, M.E, Siderovski, D.P, Sondek, J.
登録日2001-04-19
公開日2001-08-22
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA.
EMBO J., 20, 2001
5V6B
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Crystal structure of GIPC1
分子名称: PDZ domain-containing protein GIPC1
著者Shang, G, Zhang, X.
登録日2017-03-16
公開日2017-05-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex.
Elife, 6, 2017
5VWC
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Crystal structure of human Scribble PDZ1 domain
分子名称: 1,2-ETHANEDIOL, Protein scribble homolog
著者Lim, K.Y.B, Kvansakul, M.
登録日2017-05-21
公開日2017-11-08
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.911 Å)
主引用文献Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor beta-PIX.
J. Biol. Chem., 292, 2017
5W72
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Impact of IR active probes on PDZ3 and its ligand binding studied by NMR and X-ray crystallography
分子名称: Disks large homolog 4
著者Lehner, F, Kudlinzki, D, Schwalbe, H, Silvers, R.
登録日2017-06-19
公開日2017-12-13
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding.
Chembiochem, 18, 2017
4GVC
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Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in complex with phosphorylated Syndecan1 Peptide
分子名称: 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID), CHLORIDE ION, SODIUM ION, ...
著者Liu, X, Shepherd, T.R, Murray, A.M, Xu, Z, Fuentes, E.J.
登録日2012-08-30
公開日2013-03-13
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics.
Structure, 21, 2013
4HOP
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Crystal structure of the computationally designed NNOS-Syntrophin complex
分子名称: Alpha-1-syntrophin, Nitric oxide synthase, brain
著者Harwood, I.M, Melero, C, Ollikainen, N, Kortemme, T.
登録日2012-10-22
公開日2013-11-06
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Quantification of the transferability of a designed protein specificity switch reveals extensive epistasis in molecular recognition.
Proc.Natl.Acad.Sci.USA, 111, 2014
1GM1
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Second PDZ Domain (PDZ2) of PTP-BL
分子名称: PROTEIN TYROSINE PHOSPHATASE
著者Walma, T, Tessari, M, Aelen, J, Schepens, J, Hendriks, W, Vuister, G.W.
登録日2001-09-06
公開日2002-03-08
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL.
J. Mol. Biol., 316, 2002
1IU0
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The first PDZ domain of PSD-95
分子名称: PSD-95
著者Long, J.-F, Tochio, H, Wang, P, Sala, C, Niethammer, M, Sheng, M, Zhang, M.
登録日2002-02-18
公開日2003-03-11
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95
J.MOL.BIOL., 327, 2003

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