4DAT
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4DHS
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![BU of 4dhs by Molmil](/molmil-images/mine/4dhs) | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | (2-{2-[(3,5-dichlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 PROTEIN SIGMA, CHLORIDE ION, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2013-09-04 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4DNK
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![BU of 4dnk by Molmil](/molmil-images/mine/4dnk) | |
4DHN
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![BU of 4dhn by Molmil](/molmil-images/mine/4dhn) | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4DHP
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![BU of 4dhp by Molmil](/molmil-images/mine/4dhp) | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2013-09-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4E2E
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![BU of 4e2e by Molmil](/molmil-images/mine/4e2e) | |
4DHM
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![BU of 4dhm by Molmil](/molmil-images/mine/4dhm) | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4DHT
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![BU of 4dht by Molmil](/molmil-images/mine/4dht) | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | 14-3-3 PROTEIN SIGMA, CHLORIDE ION, GLYCEROL, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4DAU
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![BU of 4dau by Molmil](/molmil-images/mine/4dau) | |
4DX0
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![BU of 4dx0 by Molmil](/molmil-images/mine/4dx0) | Structure of the 14-3-3/PMA2 complex stabilized by a pyrazole derivative | 分子名称: | 14-3-3-like protein E, 4-[(4R)-4-(4-nitrophenyl)-6-oxidanylidene-3-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoic acid, N.plumbaginifolia H+-translocating ATPase mRNA | 著者 | Richter, A, Rose, R, Hedberg, C, Waldmann, H, Ottmann, C. | 登録日 | 2012-02-27 | 公開日 | 2012-05-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | An Optimised Small-Molecule Stabiliser of the 14-3-3-PMA2 Protein-Protein Interaction. Chemistry, 18, 2012
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4DHO
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![BU of 4dho by Molmil](/molmil-images/mine/4dho) | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | (2-{2-[(3-methoxyphenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 protein sigma, CHLORIDE ION, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4DHU
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![BU of 4dhu by Molmil](/molmil-images/mine/4dhu) | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | (2-{2-[(2,3-dichlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 PROTEIN SIGMA, CHLORIDE ION, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2013-09-04 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4DHQ
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![BU of 4dhq by Molmil](/molmil-images/mine/4dhq) | Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | (2-{2-[(3-chlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 protein sigma, CHLORIDE ION, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2013-09-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4F7R
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![BU of 4f7r by Molmil](/molmil-images/mine/4f7r) | |
4FR3
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![BU of 4fr3 by Molmil](/molmil-images/mine/4fr3) | Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer 16-O-Me-FC-H | 分子名称: | (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl alpha-D-glucopyranoside, 14-3-3 protein sigma, MAGNESIUM ION, ... | 著者 | Ottmann, C, Anders, C, Schumacher, B. | 登録日 | 2012-06-26 | 公開日 | 2013-05-08 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of k(+) channels at the cell surface. Chem.Biol., 20, 2013
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7OQG
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![BU of 7oqg by Molmil](/molmil-images/mine/7oqg) | |
7OQJ
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![BU of 7oqj by Molmil](/molmil-images/mine/7oqj) | |
7OQS
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7OR3
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![BU of 7or3 by Molmil](/molmil-images/mine/7or3) | Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ136 | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | 登録日 | 2021-06-04 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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7ORS
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![BU of 7ors by Molmil](/molmil-images/mine/7ors) | Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ147 | 分子名称: | (4~{S})-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]oxepane-4-carboxamide, 14-3-3 protein sigma, CHLORIDE ION, ... | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | 登録日 | 2021-06-06 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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7OQU
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![BU of 7oqu by Molmil](/molmil-images/mine/7oqu) | Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ180 | 分子名称: | (2~{S},3~{S})-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-3-methyl-2,3-dihydro-1-benzofuran-2-carboxamide, 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), ... | 著者 | Centorrino, F, Ottmann, C. | 登録日 | 2021-06-04 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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7ORG
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![BU of 7org by Molmil](/molmil-images/mine/7org) | Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ162 | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, Cyclin-dependent kinase inhibitor 1B, ... | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | 登録日 | 2021-06-05 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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7OR8
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![BU of 7or8 by Molmil](/molmil-images/mine/7or8) | Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ136 | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | 登録日 | 2021-06-04 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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7ORT
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![BU of 7ort by Molmil](/molmil-images/mine/7ort) | Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ176 | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, Cyclin-dependent kinase inhibitor 1B, ... | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | 登録日 | 2021-06-06 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove To Be Published
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7OQW
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![BU of 7oqw by Molmil](/molmil-images/mine/7oqw) | |