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PDB: 1373 件
4ICT
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BU of 4ict by Molmil
Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121
分子名称: (3S,6S)-3-benzyl-6-(4-hydroxybenzyl)piperazine-2,5-dione, Cytochrome P450 121, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Fonvielle, M, Le Du, M.-H, Lequin, O, Lecoq, A, Jacquet, M, Thai, R, Dubois, S, Grach, G, Gondry, M, Belin, P.
登録日2012-12-11
公開日2013-05-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Substrate and Reaction Specificity of Mycobacterium tuberculosis Cytochrome P450 CYP121: INSIGHTS FROM BIOCHEMICAL STUDIES AND CRYSTAL STRUCTURES.
J.Biol.Chem., 288, 2013
4J14
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BU of 4j14 by Molmil
Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound
分子名称: Cholesterol 24-hydroxylase, GLYCEROL, POSACONAZOLE, ...
著者Stout, C.D, Mast, N, Pikuleva, I.A.
登録日2013-01-31
公開日2014-01-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1.
Mol.Pharmacol., 84, 2013
4JLT
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BU of 4jlt by Molmil
Crystal structure of P450 2B4(H226Y) in complex with paroxetine
分子名称: 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, Cytochrome P450 2B4, GLYCEROL, ...
著者Shah, M.B, Pascual, J, Stout, C.D, Halpert, J.R.
登録日2013-03-13
公開日2013-06-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献A Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational States.
J.Pharmacol.Exp.Ther., 346, 2013
4K9V
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BU of 4k9v by Molmil
Complex of CYP3A4 with a desoxyritonavir analog
分子名称: 1,3-thiazol-5-ylmethyl [(3S,6S)-6-{[N-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-seryl]amino}octan-3-yl]carbamate, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE
著者Sevrioukova, I.F, Poulos, T.L.
登録日2013-04-21
公開日2013-06-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Dissecting Cytochrome P450 3A4-Ligand Interactions Using Ritonavir Analogues.
Biochemistry, 52, 2013
4KEW
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BU of 4kew by Molmil
structure of the A82F BM3 heme domain in complex with omeprazole
分子名称: 6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole, Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE
著者Leys, D.
登録日2013-04-26
公開日2013-07-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias.
J.Biol.Chem., 288, 2013
4KQ8
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BU of 4kq8 by Molmil
Structure of Recombinant Human Cytochrome P450 Aromatase
分子名称: 4-ANDROSTENE-3-17-DIONE, Cytochrome P450 19A1, PHOSPHATE ION, ...
著者Ghosh, D, Di Nardo, G, Griswold, J.
登録日2013-05-14
公開日2013-08-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.29 Å)
主引用文献Structural basis for the functional roles of critical residues in human cytochrome p450 aromatase.
Biochemistry, 52, 2013
4K9T
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Complex of CYP3A4 with a desoxyritonavir analog
分子名称: Cytochrome P450 3A4, N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-N-(4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}butyl)-L-valinamide, PROTOPORPHYRIN IX CONTAINING FE
著者Sevrioukova, I.F, Poulos, T.L.
登録日2013-04-21
公開日2013-06-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Dissecting Cytochrome P450 3A4-Ligand Interactions Using Ritonavir Analogues.
Biochemistry, 52, 2013
4KF2
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BU of 4kf2 by Molmil
Structure of the P4509 BM3 A82F F87V heme domain
分子名称: Bifunctional P-450/NADPH-P450 reductase, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE
著者Leys, D.
登録日2013-04-26
公開日2013-07-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias.
J.Biol.Chem., 288, 2013
4IPS
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BU of 4ips by Molmil
Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121
分子名称: (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazin-2-one, Cytochrome P450 121, GLYCEROL, ...
著者Fonvielle, M, LeDu, M.H, Lequin, O, Lecoq, A, Jacquet, M, Thai, R, Dubois, S, Grach, G, Gondry, M, Belin, P.
登録日2013-01-10
公開日2013-05-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Substrate and Reaction Specificity of Mycobacterium tuberculosis Cytochrome P450 CYP121: INSIGHTS FROM BIOCHEMICAL STUDIES AND CRYSTAL STRUCTURES.
J.Biol.Chem., 288, 2013
4IPW
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BU of 4ipw by Molmil
Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121
分子名称: (3S,6S)-3-(3,4-dihydroxybenzyl)-6-(4-hydroxybenzyl)piperazine-2,5-dione, Cytochrome P450 121, GLYCEROL, ...
著者Fonvielle, M, Ledu, M.H, Lequin, O, Lecoq, A, Jacquet, M, Thai, R, Dubois, S, Grach, G, Gondry, M, Belin, P.
登録日2013-01-10
公開日2013-05-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Substrate and Reaction Specificity of Mycobacterium tuberculosis Cytochrome P450 CYP121: INSIGHTS FROM BIOCHEMICAL STUDIES AND CRYSTAL STRUCTURES.
J.Biol.Chem., 288, 2013
4IQ7
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BU of 4iq7 by Molmil
Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121
分子名称: (3S,6S)-3-(4-hydroxybenzyl)-6-methylpiperazine-2,5-dione, Cytochrome P450 121, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Fonvielle, M, Ledu, M.H, Lequin, O, Lecoq, A, Jacquet, M, Thai, R, Dubois, S, Grach, G, Gondry, M, Belin, P.
登録日2013-01-11
公開日2013-05-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Substrate and Reaction Specificity of Mycobacterium tuberculosis Cytochrome P450 CYP121: INSIGHTS FROM BIOCHEMICAL STUDIES AND CRYSTAL STRUCTURES.
J.Biol.Chem., 288, 2013
4L49
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BU of 4l49 by Molmil
Structure of L358A mutant of P450cam bound to camphor
分子名称: CAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ...
著者Batabyal, D, Li, H, Poulos, T.L.
登録日2013-06-07
公開日2013-07-31
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.128 Å)
主引用文献Synergistic Effects of Mutations in Cytochrome P450cam Designed To Mimic CYP101D1.
Biochemistry, 52, 2013
4J6D
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BU of 4j6d by Molmil
The 2.4 A crystal structure of CYP154C5 from Nocardia farcinica in complex with testosterone
分子名称: Cytochrome P450 monooxygenase, FORMIC ACID, MAGNESIUM ION, ...
著者Herzog, K, Hoffmann, K.M.
登録日2013-02-11
公開日2014-03-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Enzyme-substrate complex structures of CYP154C5 shed light on its mode of highly selective steroid hydroxylation.
Acta Crystallogr.,Sect.D, 70, 2014
4J6B
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BU of 4j6b by Molmil
The 2.2 A crystal structure of CYP154C5 from Nocardia farcinica in complex with pregnenolone
分子名称: (3BETA)-3-HYDROXYPREGN-5-EN-20-ONE, Cytochrome P450 monooxygenase, FORMIC ACID, ...
著者Herzog, K, Hoffmann, K.M.
登録日2013-02-11
公開日2014-03-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Enzyme-substrate complex structures of CYP154C5 shed light on its mode of highly selective steroid hydroxylation.
Acta Crystallogr.,Sect.D, 70, 2014
4J6C
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BU of 4j6c by Molmil
The 1.9 A crystal structure of CYP154C5 from Nocardia farcinica in complex with progesterone
分子名称: Cytochrome P450 monooxygenase, FORMIC ACID, MAGNESIUM ION, ...
著者Herzog, K, Hoffmann, K.M.
登録日2013-02-11
公開日2014-03-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Enzyme-substrate complex structures of CYP154C5 shed light on its mode of highly selective steroid hydroxylation.
Acta Crystallogr.,Sect.D, 70, 2014
4JBT
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BU of 4jbt by Molmil
The 2.2 A crystal structure of CYP154C5 from Nocardia farcinica in complex with androstenedione
分子名称: 4-ANDROSTENE-3-17-DIONE, Cytochrome P450 monooxygenase, FORMIC ACID, ...
著者Herzog, K, Hoffmann, K.M.
登録日2013-02-20
公開日2014-03-05
最終更新日2014-11-12
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Enzyme-substrate complex structures of CYP154C5 shed light on its mode of highly selective steroid hydroxylation.
Acta Crystallogr.,Sect.D, 70, 2014
4L4B
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BU of 4l4b by Molmil
Structure of L358A/K178G/D182N mutant of P450cam bound to camphor
分子名称: CAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ...
著者Batabyal, D, Li, H, Poulos, T.L.
登録日2013-06-07
公開日2013-07-31
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献Synergistic Effects of Mutations in Cytochrome P450cam Designed To Mimic CYP101D1.
Biochemistry, 52, 2013
4L4G
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BU of 4l4g by Molmil
Structure of cyanide and camphor bound P450cam mutant L358P/K178G
分子名称: CAMPHOR, CYANIDE ION, Camphor 5-monooxygenase, ...
著者Batabyal, D, Li, H, Poulos, T.L.
登録日2013-06-07
公開日2013-07-31
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Synergistic Effects of Mutations in Cytochrome P450cam Designed To Mimic CYP101D1.
Biochemistry, 52, 2013
4L6G
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Crystal Structure of P450cin Y81F mutant, crystallized in 7 mM 1,8-cineole
分子名称: 1,3,3-TRIMETHYL-2-OXABICYCLO[2.2.2]OCTANE, P450cin, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Madrona, Y, Poulos, T.L.
登録日2013-06-12
公開日2013-07-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.371 Å)
主引用文献P450cin active site water: implications for substrate binding and solvent accessibility.
Biochemistry, 52, 2013
4L0F
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Structure of P450sky (CYP163B3), a cytochrome P450 from skyllamycin biosynthesis (open active site)
分子名称: 1,2-ETHANEDIOL, P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Cryle, M.J.
登録日2013-05-31
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Cytochrome p450sky interacts directly with the nonribosomal Peptide synthetase to generate three amino Acid precursors in skyllamycin biosynthesis.
Acs Chem.Biol., 8, 2013
4L36
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Crystal structure of the cytochrome P450 enzyme TxtE
分子名称: HEME B/C, IMIDAZOLE, Putative P450-like protein
著者Yu, F, Li, M.J, Xu, C.Y, Wang, Z.J, Zhou, H, Yang, M, Chen, Y.X, Tang, L, He, J.H.
登録日2013-06-05
公開日2013-12-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.104 Å)
主引用文献Structural Insights into the Mechanism for Recognizing Substrate of the Cytochrome P450 Enzyme TxtE.
Plos One, 8, 2013
4L4A
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BU of 4l4a by Molmil
Structure of L358A/K178G mutant of P450cam bound to camphor
分子名称: CAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ...
著者Batabyal, D, Li, H, Poulos, T.L.
登録日2013-06-07
公開日2013-07-31
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.103 Å)
主引用文献Synergistic Effects of Mutations in Cytochrome P450cam Designed To Mimic CYP101D1.
Biochemistry, 52, 2013
4L54
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Structure of cytochrome P450 OleT, ligand-free
分子名称: PROTOPORPHYRIN IX CONTAINING FE, Terminal olefin-forming fatty acid decarboxylase
著者Leys, D.
登録日2013-06-10
公開日2013-11-27
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 Bacterium.
J.Biol.Chem., 289, 2014
4L4F
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Structure of cyanide and camphor bound P450cam mutant L358A/K178G/D182N
分子名称: CAMPHOR, CYANIDE ION, Camphor 5-monooxygenase, ...
著者Batabyal, D, Li, H, Poulos, T.L.
登録日2013-06-07
公開日2013-07-31
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.294 Å)
主引用文献Synergistic Effects of Mutations in Cytochrome P450cam Designed To Mimic CYP101D1.
Biochemistry, 52, 2013
4LHT
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Crystal Structure of P450cin Y81F mutant, crystallized in 3 mM 1,8-cineole
分子名称: 1,3,3-TRIMETHYL-2-OXABICYCLO[2.2.2]OCTANE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Madrona, Y, Poulos, T.L.
登録日2013-07-01
公開日2013-07-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.137 Å)
主引用文献P450cin active site water: implications for substrate binding and solvent accessibility.
Biochemistry, 52, 2013

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件を2024-08-07に公開中

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