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PDB: 10 件
7K72
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BU of 7k72 by Molmil
Structure of DNA ligase A from Mycobacterium tuberculosis bound to NAD
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, DNA ligase A, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2020-09-22
公開日2020-12-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure of DNA ligase A from Mycobacterium tuberculosis bound to NAD
To Be Published
6KDU
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BU of 6kdu by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
分子名称: ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ...
著者Ramachandran, R, Shukla, A, Afsar, M.
登録日2019-07-02
公開日2020-07-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.
Acta Crystallogr D Struct Biol, 77, 2021
6KJM
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BU of 6kjm by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
分子名称: ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ...
著者Ramachandran, R, Shukla, A, Afsar, M.
登録日2019-07-22
公開日2020-07-22
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A.
J.Struct.Biol., 213, 2021
6KSC
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BU of 6ksc by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase A, SULFATE ION
著者Ramachandran, R, Shukla, A, Afsar, M.
登録日2019-08-23
公開日2020-08-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.
Acta Crystallogr D Struct Biol, 77, 2021
6LW8
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BU of 6lw8 by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
分子名称: (4R)-4-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine, DNA ligase A, GLYCEROL, ...
著者Ramachandran, R, Afsar, M, Shukla, A.
登録日2020-02-07
公開日2021-02-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.401 Å)
主引用文献Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A.
J.Struct.Biol., 213, 2021
6KSD
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BU of 6ksd by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
分子名称: BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, SULFATE ION
著者Ramachandran, R, Shukla, A, Afsar, M.
登録日2019-08-23
公開日2020-08-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.
Acta Crystallogr D Struct Biol, 77, 2021
6KKV
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BU of 6kkv by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
分子名称: DNA ligase A, N-[(4-methylphenyl)methyl]-1H-pyrrole-2-carboxamide, SULFATE ION
著者Ramachandran, R, Shukla, A, Afsar, M.
登録日2019-07-27
公開日2020-07-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A.
J.Struct.Biol., 213, 2021
6KRH
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BU of 6krh by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
分子名称: ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ...
著者Ramachandran, R, Shukla, A, Afsar, M.
登録日2019-08-21
公開日2020-08-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.
Acta Crystallogr D Struct Biol, 77, 2021
1ZAU
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BU of 1zau by Molmil
Adenylation domain of NAD+ dependent DNA ligase from M.tuberculosis
分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase
著者Srivastava, S.K, Ramachandran, R.
登録日2005-04-07
公開日2005-07-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献NAD+-dependent DNA Ligase (Rv3014c) from Mycobacterium tuberculosis: CRYSTAL STRUCTURE OF THE ADENYLATION DOMAIN AND IDENTIFICATION OF NOVEL INHIBITORS
J.Biol.Chem., 280, 2005
3SGI
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BU of 3sgi by Molmil
Crystal structure of DNA ligase A BRCT domain deleted mutant of Mycobacterium tuberculosis
分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase
著者Kukshal, V, Ravishankar, R.
登録日2011-06-15
公開日2012-06-20
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Crystal Structure of Domain deleted mutant of Mycobacterium tuberculosis NAD+ dependent DNA ligase capture the AMP cofactor in a new state
To be Published

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件を2024-07-17に公開中

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