1YVT
 
 | | The high salt (phosphate) crystal structure of CO Hemoglobin E (Glu26Lys) at physiological pH (pH 7.35) | | 分子名称: | CARBON MONOXIDE, GLYCEROL, Hemoglobin alpha chain, ... | | 著者 | Malashkevich, V.N, Balazs, T.C, Almo, S.C, Hirsch, R.E. | | 登録日 | 2005-02-16 | | 公開日 | 2006-02-28 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The high salt (phosphate) crystal structure of CO Hemoglobin E (Glu26Lys) at physiological pH (pH 7.35)
To be Published
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3QJB
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1C7D
 | | DEOXY RHB1.2 (RECOMBINANT HEMOGLOBIN) | | 分子名称: | PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)), PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)), PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Brucker, E.A. | | 登録日 | 2000-02-09 | | 公開日 | 2000-06-30 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Genetically crosslinked hemoglobin: a structural study.
Acta Crystallogr.,Sect.D, 56, 2000
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2W6V
 | | Structure of Human deoxy Hemoglobin A in complex with Xenon | | 分子名称: | GLYCEROL, HEMOGLOBIN SUBUNIT ALPHA, HEMOGLOBIN SUBUNIT BETA, ... | | 著者 | Miele, A.E, Draghi, F, Sciara, G, Johnson, K.A, Renzi, F, Vallone, B, Brunori, M, Savino, C. | | 登録日 | 2008-12-19 | | 公開日 | 2009-04-28 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Pattern of Cavities in Globins: The Case of Human Hemoglobin.
Biopolymers, 91, 2009
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1C7C
 | | DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN) | | 分子名称: | PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)), PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)), PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Brucker, E.A. | | 登録日 | 2000-02-09 | | 公開日 | 2000-06-30 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Genetically crosslinked hemoglobin: a structural study.
Acta Crystallogr.,Sect.D, 56, 2000
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1R1Y
 | | Crystal structure of deoxy-human hemoglobin Bassett at 1.8 angstrom | | 分子名称: | Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Abdulmalik, O, Safo, M.K, Lerner, N.B, Ochotorena, J, Dhaikin, Y, Abraham, D.J, Asakura, T. | | 登録日 | 2003-09-25 | | 公開日 | 2003-10-07 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Characterization of hemoglobin bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity
Am.J.Hematol., 77, 2004
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1A01
 | | HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 ALA) MUTANT | | 分子名称: | HEMOGLOBIN (ALPHA CHAIN), HEMOGLOBIN (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Kavanaugh, J.S, Arnone, A. | | 登録日 | 1997-12-08 | | 公開日 | 1998-03-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | High-resolution crystal structures of human hemoglobin with mutations at tryptophan 37beta: structural basis for a high-affinity T-state,.
Biochemistry, 37, 1998
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1A3N
 | | DEOXY HUMAN HEMOGLOBIN | | 分子名称: | HEMOGLOBIN (ALPHA CHAIN), HEMOGLOBIN (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Tame, J, Vallone, B. | | 登録日 | 1998-01-22 | | 公開日 | 1998-04-29 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The structures of deoxy human haemoglobin and the mutant Hb Tyralpha42His at 120 K.
Acta Crystallogr.,Sect.D, 56, 2000
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1YE2
 | | T-To-T(High) quaternary transitions in human hemoglobin: betaY35F oxy (2MM IHP, 20% PEG) (1 test set) | | 分子名称: | Hemoglobin alpha chain, Hemoglobin beta chain, OXYGEN MOLECULE, ... | | 著者 | Kavanaugh, J.S, Rogers, P.H, Arnone, A. | | 登録日 | 2004-12-27 | | 公開日 | 2005-01-04 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions.
Biochemistry, 44, 2005
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1O1P
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1YVQ
 | | The low salt (PEG) crystal structure of CO Hemoglobin E (betaE26K) approaching physiological pH (pH 7.5) | | 分子名称: | CARBON MONOXIDE, Hemoglobin alpha chain, Hemoglobin beta chain, ... | | 著者 | Malashkevich, V.N, Balazs, T.C, Almo, S.C, Hirsch, R.E. | | 登録日 | 2005-02-16 | | 公開日 | 2006-02-28 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structures of CO Hemoglobin E (betaE26K) approaching physiological pH (pH 7.5)
To be Published
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4L7Y
 | | Deoxygenated Hb in complex with the allosteric effectors, IRL2500 and 2,3-DPG | | 分子名称: | (2R)-2,3-diphosphoglyceric acid, (2R)-2-({(2S)-3-(biphenyl-4-yl)-2-[(3,5-dimethylbenzoyl)(methyl)amino]propanoyl}amino)-3-(1H-indol-3-yl)propanoic acid (non-preferred name), Hemoglobin subunit alpha, ... | | 著者 | Safo, M.K, Chowdhury, N. | | 登録日 | 2013-06-14 | | 公開日 | 2013-07-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Novel small molecule modulators of human hemoglobin oxygen binding identified by small molecule microarray screening
To be Published
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1CBL
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5E83
 | | CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT440, CO-CRYSTALLIZATION EXPERIMENT | | 分子名称: | 2-methyl-3-({2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl}methoxy)phenol, CARBON MONOXIDE, GLYCEROL, ... | | 著者 | Patskovska, L, Patskovsky, Y, Bonanno, J.B, Almo, S.C. | | 登録日 | 2015-10-13 | | 公開日 | 2016-07-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease.
Br.J.Haematol., 175, 2016
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1O1O
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5KSI
 | | Crystal structure of deoxygenated hemoglobin in complex with sphingosine phosphate and 2,3-Bisphosphoglycerate | | 分子名称: | (2R)-2,3-diphosphoglyceric acid, (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Hemoglobin subunit alpha, ... | | 著者 | Ahmed, M.H, Safo, M.K, Xia, Y. | | 登録日 | 2016-07-08 | | 公開日 | 2017-07-26 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease.
Sci Rep, 7, 2017
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1O1L
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3S65
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1QI8
 | | DEOXYGENATED STRUCTURE OF A DISTAL POCKET HEMOGLOBIN MUTANT | | 分子名称: | HEMOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Miele, A.E, Vallone, B, Santanche, S, Travaglini-Allocatelli, C, Bellelli, A, Brunori, M. | | 登録日 | 1999-06-07 | | 公開日 | 1999-07-11 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Modulation of ligand binding in engineered human hemoglobin distal pocket.
J.Mol.Biol., 290, 1999
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3QJE
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1C7B
 | | DEOXY RHB1.0 (RECOMBINANT HEMOGLOBIN) | | 分子名称: | PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)), PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)), PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Brucker, E.A. | | 登録日 | 2000-02-09 | | 公開日 | 2000-06-30 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | | 主引用文献 | Genetically crosslinked hemoglobin: a structural study.
Acta Crystallogr.,Sect.D, 56, 2000
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1Y4V
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1QXE
 | | Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds | | 分子名称: | 5-HYDROXYMETHYL-FURFURAL, Hemoglobin alpha chain, Hemoglobin beta chain, ... | | 著者 | Safo, M.K, Abdulmalik, O, Danso-Danquah, R, Nokuri, S, Joshi, G.S, Musayev, F.N, Asakura, T, Abraham, D.J. | | 登録日 | 2003-09-05 | | 公開日 | 2003-09-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds
J.Med.Chem., 47, 2004
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1O1M
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5URC
 | | Design, Synthesis, Functional and Biological Evaluation of Ether and Ester Derivatives of the Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease | | 分子名称: | (5-formylfuran-2-yl)methyl acetate, 5-HYDROXYMETHYL-FURFURAL, CARBON MONOXIDE, ... | | 著者 | Pagare, P.P, Safo, R.S, Gazi, A. | | 登録日 | 2017-02-10 | | 公開日 | 2017-03-15 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease.
Mol. Pharm., 14, 2017
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