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PDB: 72 件
7NG7
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Src kinase bound to eCF506 trapped in inactive conformation
分子名称: 1,2-ETHANEDIOL, Proto-oncogene tyrosine-protein kinase Src, tert-butyl (4-(4-amino-1-(2-(4-(dimethylamino)piperidin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)carbamate
著者Lietha, D, Unciti-Broceta, A.
登録日2021-02-08
公開日2021-09-15
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.
Cancer Res., 81, 2021
1FMK
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BU of 1fmk by Molmil
CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC
分子名称: TYROSINE-PROTEIN KINASE SRC
著者Xu, W, Harrison, S.C, Eck, M.J.
登録日1997-01-24
公開日1997-08-20
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Three-dimensional structure of the tyrosine kinase c-Src.
Nature, 385, 1997
2SRC
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CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP
分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TYROSINE-PROTEIN KINASE SRC
著者Xu, W, Doshi, A, Lei, M, Eck, M.J, Harrison, S.C.
登録日1998-12-29
公開日1999-07-22
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structures of c-Src reveal features of its autoinhibitory mechanism.
Mol.Cell, 3, 1999
1O43
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82129.
分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [4-((1Z)-2-(ACETYLAMINO)-3-{[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]AMINO}-3-OXOPROP-1-ENYL)-2-FORMYLPHENYL]ACET IC ACID
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4A
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82197.
分子名称: 4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-FORMYL-BENZOIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
6C4S
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Human cSrc SH3 Domain in complex with Choline Kinase fragment 60-69
分子名称: Proto-oncogene tyrosine-protein kinase Src,cSrc SH3 Domain, ZINC ION
著者Kall, S.L, Lavie, A.
登録日2018-01-12
公開日2019-01-23
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Molecular basis for the interaction between human choline kinase alpha and the SH3 domain of the c-Src tyrosine kinase.
Sci Rep, 9, 2019
1O4R
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78783.
分子名称: (PHENYL-PHOSPHONO-METHYL)-PHOSPHONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4G
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH DPI59.
分子名称: HYDROXY(1-NAPHTHYL)METHYLPHOSPHONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O48
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85053.
分子名称: 5-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXYMETHYL-BENZOIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4K
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PASBN.
分子名称: BENZYL 2-FORMYLPHENYL HYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
4F5B
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Triple mutant Src SH2 domain bound to phosphotyrosine
分子名称: O-PHOSPHOTYROSINE, Proto-oncogene tyrosine-protein kinase Src
著者Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S.
登録日2012-05-12
公開日2012-10-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
1O4M
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH MALONICACID.
分子名称: MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4N
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH OXALIC ACID.
分子名称: OXALIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4L
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH FRAGMENT2.
分子名称: CITRIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4J
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH ISO24.
分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [(4-ETHYLPHENYL)AMINO]CARBONYLPHOSPHONIC ACID
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O41
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78300.
分子名称: 2-FORMYL-6-METHOXYPHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O49
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85493.
分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, {4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENOXY}-ACETIC ACID
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O42
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU81843.
分子名称: N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-O-PHOSPHONOTYROSINAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O44
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Crystal structure of sh2 in complex with ru85052
分子名称: 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXY-PHENYL}-MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4O
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHENYLPHOSPHATE.
分子名称: PHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4Q
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79256.
分子名称: PHENYL(SULFO)ACETIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
4F59
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Triple mutant Src SH2 domain
分子名称: Proto-oncogene tyrosine-protein kinase Src
著者Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S.
登録日2012-05-12
公開日2012-10-03
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
1O4I
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PAS219.
分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, cyclohexylmethyl 2-formylphenyl hydrogen (S)-phosphate
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O47
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82209.
分子名称: N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-4-[DIFLUORO(PHOSPHONO)METHYL]PHENYLALANINAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
3VRO
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Crystal structure of the tyrosine kinase binding domain of Cbl-c in complex with phospho-Src peptide
分子名称: CALCIUM ION, Proto-oncogene tyrosine-protein kinase Src, Signal transduction protein CBL-C
著者Takeshita, K, Tezuka, T, Isozaki, Y, Yamashita, E, Suzuki, M, Yamanashi, Y, Yamamoto, T, Nakagawa, A.
登録日2012-04-13
公開日2013-03-06
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.
J.Biochem., 152, 2012

 

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