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PDB: 575 件
1AZ8
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BOVINE TRYPSIN COMPLEXED TO BIS-PHENYLAMIDINE INHIBITOR
分子名称: +/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATE, TRYPSIN
著者Alexander, R, Smallwood, A.
登録日1997-11-26
公開日1999-01-13
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Unexpected Binding Mode of a Bis-Phenylamidine Factor Xa Inhibitor Complexed to Bovine Trypsin
To be Published
3UQO
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Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
分子名称: 3-(3-carbamimidoylphenyl)-N-(2'-sulfamoylbiphenyl-4-yl)-1,2-oxazole-4-carboxamide, CALCIUM ION, Cationic trypsin
著者Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T.
登録日2011-11-21
公開日2012-11-21
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues.
Biol.Chem., 395, 2014
7BS2
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Bovine Pancreatic Trypsin with serotonin (Room Temperature)
分子名称: CALCIUM ION, Cationic trypsin, SEROTONIN, ...
著者Maeki, M, Ito, S, Takeda, R, Funakubo, T, Ueno, G, Ishida, A, Tani, H, Yamamoto, M, Tokeshi, M.
登録日2020-03-30
公開日2020-08-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Room-temperature crystallography using a microfluidic protein crystal array device and its application to protein-ligand complex structure analysis.
Chem Sci, 11, 2020
1PPC
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GEOMETRY OF BINDING OF THE BENZAMIDINE-AND ARGININE-BASED INHIBITORS N-ALPHA-(2-NAPHTHYL-SULPHONYL-GLYCYL)-DL-P-AMIDINOPHENYLALANYL-PIPERIDINE (NAPAP) AND (2R,4R)-4-METHYL-1-[N-ALPHA-(3-METHYL-1,2,3,4-TETRAHYDRO-8-QUINOLINESULPHONYL)-L-ARGINYL]-2-PIPERIDINE CARBOXYLIC ACID (MQPA) TO HUMAN ALPHA-THROMBIN: X-RAY CRYSTALLOGRAPHIC DETERMINATION OF THE NAPAP-TRYPSIN COMPLEX AND MODELING OF NAPAP-THROMBIN AND MQPA-THROMBIN
分子名称: 1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimidoyl-D-phenylalanyl]piperidine, CALCIUM ION, TRYPSIN
著者Bode, W, Turk, D.
登録日1991-10-24
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Geometry of binding of the benzamidine- and arginine-based inhibitors N alpha-(2-naphthyl-sulphonyl-glycyl)-DL-p-amidinophenylalanyl-pipe ridine (NAPAP) and (2R,4R)-4-methyl-1-[N alpha-(3-methyl-1,2,3,4-tetrahydr quinolinesulphonyl)-L-arginyl]-2-piperidine carboxylic acid (MQPA) to human alpha-thrombin.X-ray crystallographic determination of the NAPAP-trypsin complex and modeling of NAPAP-thrombin and MQPA-thrombin.
Eur.J.Biochem., 193, 1990
1G3B
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BOVINE BETA-TRYPSIN BOUND TO META-AMIDINO SCHIFF BASE MAGNESIUM(II) CHELATE
分子名称: 2-(5-CARBAMIMIDOYL-2-HYDROXY-BENZYLAMINO)-PROPIONIC ACID, BETA-TRYPSIN, CALCIUM ION, ...
著者Toyota, E, Ng, K.K.S, Sekizaki, H, Itoh, K, Tanizawa, K, James, M.N.G.
登録日2000-10-23
公開日2001-01-17
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-ray crystallographic analyses of complexes between bovine beta-trypsin and Schiff base copper(II) or iron(III) chelates.
J.Mol.Biol., 305, 2001
1Y3U
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TRYPSIN INHIBITOR COMPLEX
分子名称: (1R,3AS,4R,8AS,8BR)-4-(2-BENZO[1,3]DIOXOL-5-YLMETHYL-1-ISOPROPYL-3-OXO-DECAHYDRO-PYRROLO[3,4-A]PYRROLIZIN-4-YL)-BENZAMIDINE, CALCIUM ION, Trypsin, ...
著者Fokkens, J, Obst, U, Heine, A, Diederich, F, Klebe, G.
登録日2004-11-26
公開日2005-12-06
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and Thermodynamic Characterisation of Protein-Inhibitor-Complexes of Thrombin and Trypsin Inhibitors
To be Published
3V12
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Bovine trypsin variant X(tripleGlu217Phe227) in complex with small molecule inhibitor
分子名称: CALCIUM ION, Cationic trypsin, GLYCEROL, ...
著者Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T.
登録日2011-12-09
公開日2012-12-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues.
Biol.Chem., 395, 2014
1TGC
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ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY
分子名称: CALCIUM ION, TRYPSINOGEN
著者Walter, J, Steigemann, W, Singh, T.P, Bartunik, H, Bode, W, Huber, R.
登録日1981-10-26
公開日1982-03-04
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献On the Disordered Activation Domain in Trypsinogen. Chemical Labelling and Low-Temperature Crystallography
Acta Crystallogr.,Sect.B, 38, 1982
2ZDL
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BU of 2zdl by Molmil
Exploring trypsin S3 pocket
分子名称: (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide, CALCIUM ION, Cationic trypsin, ...
著者Baum, B, Brandt, T, Heine, A, Klebe, G.
登録日2007-11-26
公開日2008-10-14
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Congeneric but still distinct: how closely related trypsin ligands exhibit different thermodynamic and structural properties
J.Mol.Biol., 405, 2011
1TNJ
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PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
分子名称: 2-PHENYLETHYLAMINE, CALCIUM ION, TRYPSIN
著者Kurinov, I, Harrison, R.W.
登録日1994-07-21
公開日1994-11-30
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Prediction of new serine proteinase inhibitors.
Nat.Struct.Biol., 1, 1994
1TNH
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PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
分子名称: 4-FLUOROBENZYLAMINE, CALCIUM ION, TRYPSIN
著者Kurinov, I, Harrison, R.W.
登録日1994-07-21
公開日1994-11-30
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Prediction of new serine proteinase inhibitors.
Nat.Struct.Biol., 1, 1994
1G3D
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BU of 1g3d by Molmil
BOVINE BETA-TRYPSIN BOUND TO META-AMIDINO SCHIFF BASE COPPER (II) CHELATE
分子名称: 2-(5-CARBAMIMIDOYL-2-HYDROXY-BENZYLAMINO)-PROPIONIC ACID, BETA-TRYPSIN, CALCIUM ION, ...
著者Toyota, E, Ng, K.K.S, Sekizaki, H, Itoh, K, Tanizawa, K, James, M.N.G.
登録日2000-10-23
公開日2001-01-17
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-ray crystallographic analyses of complexes between bovine beta-trypsin and Schiff base copper(II) or iron(III) chelates.
J.Mol.Biol., 305, 2001
3UNS
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BU of 3uns by Molmil
Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
分子名称: CALCIUM ION, Cationic trypsin, GLYCEROL, ...
著者Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T.
登録日2011-11-16
公開日2012-11-21
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues.
Biol.Chem., 395, 2014
1NTP
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BU of 1ntp by Molmil
USE OF THE NEUTRON DIFFRACTION H/D EXCHANGE TECHNIQUE TO DETERMINE THE CONFORMATIONAL DYNAMICS OF TRYPSIN
分子名称: BETA-TRYPSIN, PHOSPHORYLISOPROPANE
著者Kossiakoff, A.A.
登録日1987-09-16
公開日1988-01-16
最終更新日2017-11-29
実験手法NEUTRON DIFFRACTION (1.8 Å)
主引用文献Use of the neutron diffraction--H/D exchange technique to determine the conformational dynamics of trypsin
Basic Life Sci., 27, 1984
1TNG
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PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS
分子名称: AMINOMETHYLCYCLOHEXANE, CALCIUM ION, TRYPSIN
著者Kurinov, I, Harrison, R.W.
登録日1994-07-21
公開日1994-11-30
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Prediction of new serine proteinase inhibitors.
Nat.Struct.Biol., 1, 1994
1G3C
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BU of 1g3c by Molmil
BOVINE BETA-TRYPSIN BOUND TO PARA-AMIDINO SCHIFF BASE IRON(III) CHELATE
分子名称: 2-(4-CARBAMIMIDOYL-2-HYDROXY-BENZYLAMINO)-PROPIONIC ACID, BETA-TRYPSIN, CALCIUM ION, ...
著者Toyota, E, Ng, K.K.S, Sekizaki, H, Itoh, K, Tanizawa, K, James, M.N.G.
登録日2000-10-23
公開日2001-01-17
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-ray crystallographic analyses of complexes between bovine beta-trypsin and Schiff base copper(II) or iron(III) chelates.
J.Mol.Biol., 305, 2001
1G3E
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BU of 1g3e by Molmil
BOVINE BETA-TRYPSIN BOUND TO PARA-AMIDINO SCHIFF-BASE COPPER (II) CHELATE
分子名称: 2-(4-CARBAMIMIDOYL-2-HYDROXY-BENZYLAMINO)-PROPIONIC ACID, BETA-TRYPSIN, CALCIUM ION, ...
著者Toyota, E, Ng, K.K.S, Sekizaki, H, Itoh, K, Tanizawa, K, James, M.N.G.
登録日2000-10-23
公開日2001-01-17
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-ray crystallographic analyses of complexes between bovine beta-trypsin and Schiff base copper(II) or iron(III) chelates.
J.Mol.Biol., 305, 2001
3A89
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BU of 3a89 by Molmil
Crystal Structure of Trypsin complexed with (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide (soaking 4 hours)
分子名称: (E)-4-((2-nicotinoylhydrazono)methyl)benzimidamide, CALCIUM ION, Cationic trypsin, ...
著者Yamane, J, Yao, M, Tanaka, I.
登録日2009-10-05
公開日2010-09-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献In-Crystal Chemical Ligation for Drug Discovery
To be Published
3A7Z
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Crystal Structure of Trypsin complexed with (E)-4-((1-methylpiperidin-4-yloxyimino)methyl)benzimidamide (soaking 3hours)
分子名称: (E)-4-((1-methylpiperidin-4-yloxyimino)methyl)benzimidamide, CALCIUM ION, Cationic trypsin, ...
著者Yamane, J, Yao, M, Tanaka, I.
登録日2009-10-05
公開日2010-09-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献In-Crystal Chemical Ligation for Drug Discovery
To be Published
1TGB
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BU of 1tgb by Molmil
CRYSTAL STRUCTURE OF BOVINE TRYPSINOGEN AT 1.8 ANGSTROMS RESOLUTION. II. CRYSTALLOGRAPHIC REFINEMENT, REFINED CRYSTAL STRUCTURE AND COMPARISON WITH BOVINE TRYPSIN
分子名称: CALCIUM ION, TRYPSINOGEN
著者Bode, W, Fehlhammer, H, Huber, R.
登録日1979-03-07
公開日1979-06-13
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of bovine trypsinogen at 1-8 A resolution. II. Crystallographic refinement, refined crystal structure and comparison with bovine trypsin.
J.Mol.Biol., 111, 1977
1BJV
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BU of 1bjv by Molmil
BETA-TRYPSIN COMPLEXED WITH APPU
分子名称: 1-(2-AMIDINOPHENYL)-3-(PHENOXYPHENYL)UREA, BETA-TRYPSIN, CALCIUM ION, ...
著者Presnell, S, Patil, G, Mura, C, Jude, K, Conley, J, Kam, C, Bertrand, J, Powers, J, Williams, L.
登録日1998-06-29
公開日1998-12-02
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Oxyanion-mediated inhibition of serine proteases.
Biochemistry, 37, 1998
1BJU
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BU of 1bju by Molmil
BETA-TRYPSIN COMPLEXED WITH ACPU
分子名称: 1-(4-AMIDINOPHENYL)-3-(4-CHLOROPHENYL)UREA, BETA-TRYPSIN, CALCIUM ION, ...
著者Presnell, S, Patil, G, Mura, C, Jude, K, Conley, J, Kam, C, Bertrand, J, Powers, J, Williams, L.
登録日1998-06-29
公開日1998-12-02
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Oxyanion-mediated inhibition of serine proteases.
Biochemistry, 37, 1998
1V2V
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Benzamidine in complex with bovine trypsin variant X(SSAI)bT.C1
分子名称: BENZAMIDINE, CALCIUM ION, SULFATE ION, ...
著者Rauh, D, Klebe, G, Stubbs, M.T.
登録日2003-10-17
公開日2004-06-01
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Understanding protein-ligand interactions: the price of protein flexibility
J.Mol.Biol., 335, 2004
1V2N
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BU of 1v2n by Molmil
Potent factor XA inhibitor in complex with bovine trypsin variant X(99/175/190)bT
分子名称: 2,7-BIS-(4-AMIDINOBENZYLIDENE)-CYCLOHEPTAN-1-ONE, CALCIUM ION, Trypsin
著者Rauh, D, Klebe, G, Stubbs, M.T.
登録日2003-10-17
公開日2004-06-01
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Understanding protein-ligand interactions: the price of protein flexibility
J.Mol.Biol., 335, 2004
1QBN
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Bovine Trypsin 2-[amino(imino)methyl]-2-hydroxyphenoxy]-6-[3-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridine-4-carboxylic Acid (ZK-806688) Complex
分子名称: 2-[AMINO(IMINO)METHYL]-2-HYDROXYPHENOXY]-6-[3-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)PHENOXY]PYRIDINE-4-CARBOXYLIC ACID, CALCIUM ION, PROTEIN (TRYPSIN)
著者Whitlow, M.
登録日1999-04-25
公開日2000-05-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin.
Acta Crystallogr.,Sect.D, 55, 1999

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