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PDB: 6 件
8W23
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BU of 8w23 by Molmil
Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, TDI-2804 (consensus map).
分子名称: Maltose/maltodextrin-binding periplasmic protein,Poly [ADP-ribose] polymerase tankyrase-2, N-{2-[4-(2-hydroxypropan-2-yl)phenyl]-4-oxo-1,4-dihydroquinazolin-7-yl}-4-methoxy-6-phenylpyridine-3-carboxamide, ZINC ION
著者Malone, B.F, Zimmerman, J.L, Dow, L.E, Hite, R.K.
登録日2024-02-19
公開日2025-07-09
実験手法ELECTRON MICROSCOPY (2.28 Å)
主引用文献A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression.
Biorxiv, 2025
8W25
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BU of 8w25 by Molmil
Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, TDI-2804 (focused refinement map).
分子名称: Maltose/maltodextrin-binding periplasmic protein,Poly [ADP-ribose] polymerase tankyrase-2, N-{2-[4-(2-hydroxypropan-2-yl)phenyl]-4-oxo-1,4-dihydroquinazolin-7-yl}-4-methoxy-6-phenylpyridine-3-carboxamide, ZINC ION
著者Malone, B.F, Zimmerman, J.L, Dow, L.E, Hite, R.K.
登録日2024-02-20
公開日2025-07-09
実験手法ELECTRON MICROSCOPY (2.42 Å)
主引用文献A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression.
Biorxiv, 2025
8W2T
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BU of 8w2t by Molmil
Cryo-EM structure of human tankyrase 2 SAM-PARP filament - apo state (focused refinement map).
分子名称: Poly [ADP-ribose] polymerase tankyrase-2, ZINC ION
著者Malone, B.F, Zimmerman, J.L, Dow, L.E, Hite, R.K.
登録日2024-02-21
公開日2025-07-09
実験手法ELECTRON MICROSCOPY (2.52 Å)
主引用文献A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression.
Biorxiv, 2025
8W28
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BU of 8w28 by Molmil
Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, XAV (focused refinement map).
分子名称: 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, Maltose/maltodextrin-binding periplasmic protein,Poly [ADP-ribose] polymerase tankyrase-2, ZINC ION
著者Malone, B.F, Zimmerman, J.L, Dow, L.E, Hite, R.K.
登録日2024-02-20
公開日2025-07-09
実験手法ELECTRON MICROSCOPY (2.19 Å)
主引用文献A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression.
Biorxiv, 2025
8W2U
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BU of 8w2u by Molmil
Cryo-EM structure of human tankyrase 2 SAM-PARP filament -apo state (consensus map).
分子名称: Poly [ADP-ribose] polymerase tankyrase-2, ZINC ION
著者Malone, B.F, Zimmerman, J.L, Dow, L.E, Hite, R.K.
登録日2024-02-21
公開日2025-07-09
実験手法ELECTRON MICROSCOPY (2.46 Å)
主引用文献A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression.
Biorxiv, 2025
8W27
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BU of 8w27 by Molmil
Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, XAV (consensus map).
分子名称: 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, Maltose/maltodextrin-binding periplasmic protein,Poly [ADP-ribose] polymerase tankyrase-2, ZINC ION
著者Malone, B.F, Zimmerman, J.L, Dow, L.E, Hite, R.K.
登録日2024-02-20
公開日2025-07-09
実験手法ELECTRON MICROSCOPY (2.21 Å)
主引用文献A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression.
Biorxiv, 2025

238582

件を2025-07-09に公開中

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