8T1D
| Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD | 分子名称: | (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T1F
| Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T1B
| Cryo-EM structure of full-length human TRPV4 in apo state | 分子名称: | (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera, ... | 著者 | Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T1C
| Cryo-EM structure of human TRPV4 ankyrin repeat domain in complex with GTPase RhoA | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4-Enhanced green fluorescent protein chimera | 著者 | Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T1E
| Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD | 分子名称: | (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4,Enhanced green fluorescent protein, ... | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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