8BPW
 
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8BPV
 | | Crystal structure of JAK2 JH1 in complex with pacritinib | | 分子名称: | 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene, Tyrosine-protein kinase JAK2 | | 著者 | Miao, Y, Haikarainen, T. | | 登録日 | 2022-11-18 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity.
J.Med.Chem., 67, 2024
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8BM2
 | | Crystal structure of JAK2 JH1 in complex with gandotinib | | 分子名称: | 3-[(4-chloranyl-2-fluoranyl-phenyl)methyl]-2-methyl-~{N}-(5-methyl-1~{H}-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine, Tyrosine-protein kinase JAK2 | | 著者 | Miao, Y, Haikarainen, T. | | 登録日 | 2022-11-10 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity.
J.Med.Chem., 67, 2024
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8BX6
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8BXH
 | | Crystal structure of JAK2 JH1 in complex with momelotinib | | 分子名称: | MALONATE ION, Momelotinib, Tyrosine-protein kinase JAK2 | | 著者 | Haikarainen, T. | | 登録日 | 2022-12-08 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity.
J.Med.Chem., 67, 2024
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8BXC
 | | Crystal structure of JAK2 JH1 in complex with itacitinib | | 分子名称: | Itacitinib, MALONATE ION, Tyrosine-protein kinase JAK2 | | 著者 | Haikarainen, T. | | 登録日 | 2022-12-08 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity.
J.Med.Chem., 67, 2024
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8BX9
 | | Crystal structure of JAK2 JH1 in complex with ilginatinib | | 分子名称: | DIMETHYL SULFOXIDE, Ilginatinib, Tyrosine-protein kinase JAK2 | | 著者 | Haikarainen, T. | | 登録日 | 2022-12-08 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity.
J.Med.Chem., 67, 2024
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