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PDB: 11 件
8V7I
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BU of 8v7i by Molmil
Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 1 mM Mg2+ for 1800s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Sugar ring alignment and dynamics underline cytarabine and gemcitabine inhibition on Pol eta catalyzed DNA synthesis.
J.Biol.Chem., 300, 2024
8V7C
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BU of 8v7c by Molmil
Human DNA polymerase eta-DNA-dT primer gemCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion
分子名称: 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Sugar ring alignment and dynamics underline cytarabine and gemcitabine inhibition on Pol eta catalyzed DNA synthesis.
J.Biol.Chem., 300, 2024
8V7K
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BU of 8v7k by Molmil
Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 10 mM Mn2+ for 1800s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Sugar ring alignment and dynamics underline cytarabine and gemcitabine inhibition on Pol eta catalyzed DNA synthesis.
J.Biol.Chem., 300, 2024
8V7A
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BU of 8v7a by Molmil
Human DNA polymerase eta-DNA-dT primer dCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Sugar ring alignment and dynamics underline cytarabine and gemcitabine inhibition on Pol eta catalyzed DNA synthesis.
J.Biol.Chem., 300, 2024
8V7H
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BU of 8v7h by Molmil
Human DNA polymerase eta-DNA-araC-ended primer ternary complex:ground state at pH7.0 (K+ MES) with 1 Ca2+ ion
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Sugar ring alignment and dynamics underline cytarabine and gemcitabine inhibition on Pol eta catalyzed DNA synthesis.
J.Biol.Chem., 300, 2024
8V7J
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BU of 8v7j by Molmil
Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 20 mM Mg2+ for 600s
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Sugar ring alignment and dynamics underline cytarabine and gemcitabine inhibition on Pol eta catalyzed DNA synthesis.
J.Biol.Chem., 300, 2024
8V7F
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BU of 8v7f by Molmil
Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mn2+
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), DNA (5'-D(*CP*AP*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Sugar ring alignment and dynamics underline cytarabine and gemcitabine inhibition on Pol eta catalyzed DNA synthesis.
J.Biol.Chem., 300, 2024
8V7E
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BU of 8v7e by Molmil
Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mg2+
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*C)-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Sugar ring alignment and dynamics underline cytarabine and gemcitabine inhibition on Pol eta catalyzed DNA synthesis.
J.Biol.Chem., 300, 2024
8V7D
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BU of 8v7d by Molmil
Human DNA polymerase eta-DNA-dT primer rCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion
分子名称: CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Sugar ring alignment and dynamics underline cytarabine and gemcitabine inhibition on Pol eta catalyzed DNA synthesis.
J.Biol.Chem., 300, 2024
8V7B
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BU of 8v7b by Molmil
Human DNA polymerase eta-DNA-dT primer araCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion
分子名称: 4-amino-1-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}pyrimidin-2(1H)-one, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Sugar ring alignment and dynamics underline cytarabine and gemcitabine inhibition on Pol eta catalyzed DNA synthesis.
J.Biol.Chem., 300, 2024
8V7G
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BU of 8v7g by Molmil
Human DNA polymerase eta-DNA-gemC-ended primer-dAMPNPP ternary complex with Mg2+
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*(U7B))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Chang, C, Gao, Y.
登録日2023-12-04
公開日2024-05-15
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Sugar ring alignment and dynamics underline cytarabine and gemcitabine inhibition on Pol eta catalyzed DNA synthesis.
J.Biol.Chem., 300, 2024

239149

件を2025-07-23に公開中

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