9EQJ
 
 | | Crystal structure of pVHL:EloB:EloC in complex with MP-1-39 | | 分子名称: | (2S,4R)-1-[(2R)-2-[(1-fluoranylcyclopropyl)carbonylamino]-3-methyl-3-[[cis-4-(morpholin-4-ylmethyl)cyclohexyl]methylsulfanyl]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | | 著者 | Kroupova, A, Pierri, M, Liu, X, Ciulli, A. | | 登録日 | 2024-03-21 | | 公開日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity.
Bioorg.Med.Chem.Lett., 110, 2024
|
|
9EQM
 | | Crystal structure of pVHL:EloB:EloC in complex with MP-1-21 | | 分子名称: | (2S,4R)-1-[(2R)-2-[(1-fluoranylcyclopropyl)carbonylamino]-3-methyl-3-[[trans-4-(morpholin-4-ylmethyl)cyclohexyl]methylsulfanyl]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | | 著者 | Kroupova, A, Pierri, M, Liu, X, Ciulli, A. | | 登録日 | 2024-03-21 | | 公開日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity.
Bioorg.Med.Chem.Lett., 110, 2024
|
|
