PDB クエリの検索結果 - 日本蛋白質構造データバンク

PDB: 2 件

X-Ray Co-structure of Rho-Associated Protein Kinase (ROCK1) with a potent 2H-isoquinolin-1-one inhibitor
分子名称:	Rho-associated protein kinase 1, cis-4-amino-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)cyclohexanecarboxamide
著者	Li, X.
登録日	2010-06-06
公開日	2010-12-08
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive rats. Bioorg.Med.Chem.Lett., 20, 2010

Crystal structure of Rho-Associated Protein Kinase (ROCK1) with a potent isoquinolone derivative
分子名称:	(3S,4R)-N-(7-chloro-1-oxo-1,4-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide, Rho-Associated Protein Kinase (ROCK1)
著者	Li, X.
登録日	2010-06-07
公開日	2010-12-08
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (3.3 Å)
主引用文献	Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines. Bioorg.Med.Chem.Lett., 20, 2010