2IHN
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![BU of 2ihn by Molmil](/molmil-images/mine/2ihn) | Co-crystal of Bacteriophage T4 RNase H with a fork DNA substrate | Descriptor: | 5'-D(*CP*TP*AP*AP*CP*TP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*CP*C)-3', 5'-D(*GP*GP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*TP*AP*GP*TP*CP*AP*A)-3', Ribonuclease H | Authors: | Devos, J.M, Mueser, T.C. | Deposit date: | 2006-09-26 | Release date: | 2007-08-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of bacteriophage T4 5' nuclease in complex with a branched DNA reveals how FEN-1 family nucleases bind their substrates. J.Biol.Chem., 282, 2007
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3H7I
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![BU of 3h7i by Molmil](/molmil-images/mine/3h7i) | Structure of the metal-free D132N T4 RNase H | Descriptor: | Ribonuclease H, SULFATE ION | Authors: | Tomanicek, S.J, Mueser, T.C. | Deposit date: | 2009-04-27 | Release date: | 2010-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.502 Å) | Cite: | Additional Order Appears in the Absence of Metals in a FEN-1 protein: Structural Analysis of Magnesium Binding to Bacteriophage T4 RNaseH To be Published
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3H8J
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![BU of 3h8j by Molmil](/molmil-images/mine/3h8j) | |
3H8S
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![BU of 3h8s by Molmil](/molmil-images/mine/3h8s) | |
3H8W
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![BU of 3h8w by Molmil](/molmil-images/mine/3h8w) | |
1TFR
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![BU of 1tfr by Molmil](/molmil-images/mine/1tfr) | RNASE H FROM BACTERIOPHAGE T4 | Descriptor: | MAGNESIUM ION, T4 RNASE H | Authors: | Mueser, T.C, Nossal, N.G, Hyde, C.C. | Deposit date: | 1996-04-27 | Release date: | 1996-11-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Structure of bacteriophage T4 RNase H, a 5' to 3' RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins. Cell(Cambridge,Mass.), 85, 1996
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6VDE
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![BU of 6vde by Molmil](/molmil-images/mine/6vde) | Full-length M. smegmatis Pol1 | Descriptor: | DNA polymerase I, MANGANESE (II) ION | Authors: | Shuman, S, Goldgur, Y, Ghosh, S. | Deposit date: | 2019-12-24 | Release date: | 2020-02-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.713 Å) | Cite: | Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme. Nucleic Acids Res., 48, 2020
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1XO1
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![BU of 1xo1 by Molmil](/molmil-images/mine/1xo1) | T5 5'-EXONUCLEASE MUTANT K83A | Descriptor: | 5'-EXONUCLEASE | Authors: | Ceska, T.A, Suck, D, Sayers, J.R. | Deposit date: | 1998-11-19 | Release date: | 1999-04-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mutagenesis of conserved lysine residues in bacteriophage T5 5'-3' exonuclease suggests separate mechanisms of endo-and exonucleolytic cleavage. Proc.Natl.Acad.Sci.USA, 96, 1999
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1BGX
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![BU of 1bgx by Molmil](/molmil-images/mine/1bgx) | TAQ POLYMERASE IN COMPLEX WITH TP7, AN INHIBITORY FAB | Descriptor: | TAQ DNA POLYMERASE, TP7 MAB | Authors: | Murali, R, Sharkey, D.J, Daiss, J.L, Krishna Murthy, H.M. | Deposit date: | 1998-06-02 | Release date: | 1998-10-14 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of Taq DNA polymerase in complex with an inhibitory Fab: the Fab is directed against an intermediate in the helix-coil dynamics of the enzyme. Proc.Natl.Acad.Sci.USA, 95, 1998
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1EXN
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![BU of 1exn by Molmil](/molmil-images/mine/1exn) | T5 5'-EXONUCLEASE | Descriptor: | 5'-EXONUCLEASE | Authors: | Ceska, T.A, Sayers, J.R, Stier, G, Suck, D. | Deposit date: | 1997-01-17 | Release date: | 1997-07-07 | Last modified: | 2018-04-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A helical arch allowing single-stranded DNA to thread through T5 5'-exonuclease. Nature, 382, 1996
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5HML
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![BU of 5hml by Molmil](/molmil-images/mine/5hml) | Crystal Structure of T5 D15 Protein Co-crystallized with Metal Ions | Descriptor: | 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | Authors: | Flemming, C.S, Feng, M, Sedelnikova, S.E, Zhang, J, Rafferty, J.B, Sayers, J.R, Artymiuk, P.J. | Deposit date: | 2016-01-16 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.482 Å) | Cite: | Direct observation of DNA threading in flap endonuclease complexes. Nat.Struct.Mol.Biol., 23, 2016
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5HMM
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![BU of 5hmm by Molmil](/molmil-images/mine/5hmm) | Crystal Structure of T5 D15 Protein Co-crystallized with Metal Ions | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Exodeoxyribonuclease, ... | Authors: | Flemming, C.S, Sedelnikova, S.E, Rafferty, J.B, Sayers, J.R, Artymiuk, P.J. | Deposit date: | 2016-01-16 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Direct observation of DNA threading in flap endonuclease complexes. Nat.Struct.Mol.Biol., 23, 2016
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5HP4
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![BU of 5hp4 by Molmil](/molmil-images/mine/5hp4) | Crystal structure bacteriohage T5 D15 flap endonuclease (D155K) pseudo-enzyme-product complex with DNA and metal ions | Descriptor: | CALCIUM ION, DNA (5'-D(*GP*AP*TP*CP*TP*AP*TP*AP*TP*GP*CP*CP*AP*TP*CP*GP*G)-3'), Exodeoxyribonuclease, ... | Authors: | Almalki, F.A, Zhang, J, Sedelnikova, S.E, Rafferty, J.B, Sayers, J.R, Artymiuk, P.A. | Deposit date: | 2016-01-20 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Direct observation of DNA threading in flap endonuclease complexes. Nat.Struct.Mol.Biol., 23, 2016
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6C34
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![BU of 6c34 by Molmil](/molmil-images/mine/6c34) | Mycobacterium smegmatis DNA flap endonuclease mutant D125N | Descriptor: | 5'-3' exonuclease, MANGANESE (II) ION | Authors: | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | Deposit date: | 2018-01-09 | Release date: | 2018-03-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities. Nucleic Acids Res., 46, 2018
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5HNK
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![BU of 5hnk by Molmil](/molmil-images/mine/5hnk) | Crystal structure of T5Fen in complex intact substrate and metal ions. | Descriptor: | DNA (5'-D(*AP*AP*AP*AP*GP*CP*GP*TP*AP*CP*GP*C)-3'), Exodeoxyribonuclease, GLYCEROL, ... | Authors: | Almalki, F.A, Feng, M, Zhang, J, Sedelnikova, S.E, Rafferty, J.B, Sayers, J.R, Artymiuk, P.J. | Deposit date: | 2016-01-18 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Direct observation of DNA threading in flap endonuclease complexes. Nat.Struct.Mol.Biol., 23, 2016
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6C36
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![BU of 6c36 by Molmil](/molmil-images/mine/6c36) | Mycobacterium smegmatis flap endonuclease mutant D208N | Descriptor: | 5'-3' exonuclease, MANGANESE (II) ION, PHOSPHATE ION | Authors: | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | Deposit date: | 2018-01-09 | Release date: | 2018-03-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities. Nucleic Acids Res., 46, 2018
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6C33
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![BU of 6c33 by Molmil](/molmil-images/mine/6c33) | Mycobacterium smegmatis DNA flap endonuclease | Descriptor: | 5'-3' exonuclease, MANGANESE (II) ION | Authors: | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | Deposit date: | 2018-01-09 | Release date: | 2018-03-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities. Nucleic Acids Res., 46, 2018
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6C35
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![BU of 6c35 by Molmil](/molmil-images/mine/6c35) | Mycobacterium smegmatis flap endonuclease mutant D148N | Descriptor: | 5'-3' exonuclease, MANGANESE (II) ION | Authors: | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | Deposit date: | 2018-01-09 | Release date: | 2018-03-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.803 Å) | Cite: | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities. Nucleic Acids Res., 46, 2018
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1TAU
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![BU of 1tau by Molmil](/molmil-images/mine/1tau) | TAQ POLYMERASE (E.C.2.7.7.7)/DNA/B-OCTYLGLUCOSIDE COMPLEX | Descriptor: | 2-O-octyl-beta-D-glucopyranose, DNA (5'-D(*CP*GP*GP*AP*TP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*AP*TP*CP*CP*G)-3'), ... | Authors: | Eom, S.H, Wang, J, Steitz, T.A. | Deposit date: | 1996-06-17 | Release date: | 1997-04-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of Taq ploymerase with DNA at the polymerase active site. Nature, 382, 1996
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1UT5
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![BU of 1ut5 by Molmil](/molmil-images/mine/1ut5) | |
1UT8
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![BU of 1ut8 by Molmil](/molmil-images/mine/1ut8) | |
1TAQ
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![BU of 1taq by Molmil](/molmil-images/mine/1taq) | STRUCTURE OF TAQ DNA POLYMERASE | Descriptor: | 2-O-octyl-beta-D-glucopyranose, TAQ DNA POLYMERASE, ZINC ION | Authors: | Kim, Y, Eom, S.H, Wang, J, Lee, D.-S, Suh, S.W, Steitz, T.A. | Deposit date: | 1996-06-04 | Release date: | 1996-12-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of Thermus aquaticus DNA polymerase. Nature, 376, 1995
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3ZDA
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![BU of 3zda by Molmil](/molmil-images/mine/3zda) | Structure of E. coli ExoIX in complex with a fragment of the Flap1 DNA oligonucleotide, potassium and magnesium | Descriptor: | 5'-D(*AP*AP*GP*CP*GP*CP)-3', 5'-D(*GP*CP*GP*CP)-3', MAGNESIUM ION, ... | Authors: | Hemsworth, G.R, Anstey-Gilbert, C.S, Flemming, C.S, Hodskinson, M.R.G, Zhang, J, Sedelnikova, S.E, Stillman, T.J, Sayers, J.R, Artymiuk, P.J. | Deposit date: | 2012-11-26 | Release date: | 2013-07-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The Structure of E. Coli Exoix - Implications for DNA Binding and Catalysis in Flap Endonucleases Nucleic Acids Res., 41, 2013
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3ZDD
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![BU of 3zdd by Molmil](/molmil-images/mine/3zdd) | Structure of E. coli ExoIX in complex with the palindromic 5ov6 oligonucleotide and potassium | Descriptor: | 1,2-ETHANEDIOL, 5OV6 DNA, ISOPROPYL ALCOHOL, ... | Authors: | Flemming, C.S, Hemsworth, G.R, Anstey-Gilbert, C.S, Hodskinson, M.R.G, Zhang, J, Sedelnikova, S.E, Stillman, T.J, Sayers, J.R, Artymiuk, P.J. | Deposit date: | 2012-11-26 | Release date: | 2013-07-10 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The structure of Escherichia coli ExoIX--implications for DNA binding and catalysis in flap endonucleases. Nucleic Acids Res., 41, 2013
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3ZDE
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![BU of 3zde by Molmil](/molmil-images/mine/3zde) | Potassium free structure of E. coli ExoIX | Descriptor: | PROTEIN XNI | Authors: | Hemsworth, G.R, Anstey-Gilbert, C.S, Flemming, C.S, Hodskinson, M.R.G, Zhang, J, Sedelnikova, S.E, Stillman, T.J, Sayers, J.R, Artymiuk, P.J. | Deposit date: | 2012-11-26 | Release date: | 2013-07-10 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | The Structure of E. Coli Exoix - Implications for DNA Binding and Catalysis in Flap Endonucleases Nucleic Acids Res., 41, 2013
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