1GR0
| myo-inositol 1-phosphate synthase from Mycobacterium tuberculosis in complex with NAD and zinc. | Descriptor: | CACODYLATE ION, INOSITOL-3-PHOSPHATE SYNTHASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Norman, R.A, Murray-Rust, J, McDonald, N.Q, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2001-12-10 | Release date: | 2002-03-12 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure of Inositol 1-Phosphate Synthase from Mycobacterium Tuberculosis, a Key Enzyme in Phosphatidylinositol Synthesis Structure, 10, 2002
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3CIN
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9F2K
| Myo-inositol-1-phosphate synthase from Thermochaetoides thermophila in complex with NAD | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, inositol-3-phosphate synthase | Authors: | Traeger, T.K, Kyrilis, F.L, Hamdi, F, Kastritis, P.L. | Deposit date: | 2024-04-23 | Release date: | 2024-08-14 | Last modified: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (2.48 Å) | Cite: | Disorder-to-order active site capping regulates the rate-limiting step of the inositol pathway. Proc.Natl.Acad.Sci.USA, 121, 2024
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7NWR
| Structure of BT1526, a myo-inositol-1-phosphate synthase | Descriptor: | Inositol-3-phosphate synthase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION | Authors: | Basle, A, Tang, G, Marles-Wright, J, Campopiano, D. | Deposit date: | 2021-03-17 | Release date: | 2022-03-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Characterization of inositol lipid metabolism in gut-associated Bacteroidetes. Nat Microbiol, 7, 2022
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6K96
| Crystal structure of Ari2 | Descriptor: | Five-membered-cyclitol-phosphate synthase, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Miyanaga, A, Tsunoda, T, Kudo, F, Eguchi, T. | Deposit date: | 2019-06-14 | Release date: | 2019-12-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Stereochemistry in the Reaction of themyo-Inositol Phosphate Synthase Ortholog Ari2 during Aristeromycin Biosynthesis. Biochemistry, 58, 2019
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1U1I
| Myo-inositol phosphate synthase mIPS from A. fulgidus | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PHOSPHATE ION, POTASSIUM ION, ... | Authors: | Stieglitz, K.A, Yang, H, Roberts, M.F, Stec, B. | Deposit date: | 2004-07-15 | Release date: | 2004-08-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Reaching for Mechanistic Consensus Across Life Kingdoms: Structure and Insights into Catalysis of the myo-Inositol-1-phosphate Synthase (mIPS) from Archaeoglobus fulgidus Biochemistry, 44, 2005
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1JKF
| Holo 1L-myo-inositol-1-phosphate Synthase | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, myo-inositol-1-phosphate synthase | Authors: | Stein, A.J, Geiger, J.H. | Deposit date: | 2001-07-12 | Release date: | 2002-04-10 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The crystal structure and mechanism of 1-L-myo-inositol- 1-phosphate synthase J.Biol.Chem., 277, 2002
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1LA2
| Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase | Descriptor: | Myo-inositol-1-phosphate synthase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Kniewel, R, Buglino, J.A, Shen, V, Chadna, T, Beckwith, A, Lima, C.D, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2002-03-27 | Release date: | 2002-04-10 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase J.STRUCT.FUNCT.GENOM., 2, 2002
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1JKI
| myo-Inositol-1-phosphate Synthase Complexed with an Inhibitor, 2-deoxy-glucitol-6-phosphate | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-DEOXY-GLUCITOL-6-PHOSPHATE, AMMONIUM ION, ... | Authors: | Stein, A.J, Geiger, J.H. | Deposit date: | 2001-07-12 | Release date: | 2002-04-10 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structure and mechanism of 1-L-myo-inositol- 1-phosphate synthase J.Biol.Chem., 277, 2002
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3QW2
| L-myo-inositol 1-phosphate synthase from Archaeoglobus mutant N255A | Descriptor: | GLYCEROL, Myo-inositol-1-phosphate synthase (Ino1), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Neelon, K, Roberts, M.F, Stec, B. | Deposit date: | 2011-02-26 | Release date: | 2012-01-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Crystal structure of a trapped catalytic intermediate suggests that forced atomic proximity drives the catalysis of mIPS. Biophys.J., 101, 2011
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3QVW
| L-myo-inositol 1-phosphate synthase from Archaeoglobus fulgidus mutant K278A | Descriptor: | GLYCEROL, Myo-inositol-1-phosphate synthase (Ino1), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Neelon, K, Roberts, M.F, Stec, B. | Deposit date: | 2011-02-26 | Release date: | 2012-01-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a trapped catalytic intermediate suggests that forced atomic proximity drives the catalysis of mIPS. Biophys.J., 101, 2011
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3QVS
| L-myo-inositol 1-phosphate synthase from Archaeoglobus fulgidus wild type | Descriptor: | GLYCEROL, Myo-inositol-1-phosphate synthase (Ino1), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Neelon, K, Roberts, M.F, Stec, B. | Deposit date: | 2011-02-25 | Release date: | 2012-01-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of a trapped catalytic intermediate suggests that forced atomic proximity drives the catalysis of mIPS. Biophys.J., 101, 2011
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3QVT
| L-myo-inositol 1-phosphate synthase from Archaeoglobus fulgidus wild-type with the intermediate 5-keto 1-phospho glucose | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, Myo-inositol-1-phosphate synthase (Ino1), ... | Authors: | Neelon, K, Roberts, M.F, Stec, B. | Deposit date: | 2011-02-25 | Release date: | 2012-01-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a trapped catalytic intermediate suggests that forced atomic proximity drives the catalysis of mIPS. Biophys.J., 101, 2011
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3QVX
| L-myo-inositol 1-phosphate synthase from Archaeoglobus fulgidus mutant K367A | Descriptor: | GLYCEROL, Myo-inositol-1-phosphate synthase (Ino1), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Neelon, K, Roberts, M.F, Stec, B. | Deposit date: | 2011-02-26 | Release date: | 2012-01-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of a trapped catalytic intermediate suggests that forced atomic proximity drives the catalysis of mIPS. Biophys.J., 101, 2011
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1P1K
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1P1H
| Crystal structure of the 1L-myo-inositol/NAD+ complex | Descriptor: | Inositol-3-phosphate synthase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Jin, X, Geiger, J.H. | Deposit date: | 2003-04-12 | Release date: | 2003-07-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structures of NAD(+)- and NADH-bound 1-l-myo-inositol 1-phosphate synthase. Acta Crystallogr.,Sect.D, 59, 2003
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1P1J
| Crystal structure of the 1L-myo-inositol 1-phosphate synthase complexed with NADH | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, Inositol-3-phosphate synthase, ... | Authors: | Jin, X, Geiger, J.H. | Deposit date: | 2003-04-12 | Release date: | 2003-07-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structures of NAD(+)- and NADH-bound 1-l-myo-inositol 1-phosphate synthase. Acta Crystallogr.,Sect.D, 59, 2003
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1P1F
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1P1I
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1RM0
| Crystal Structure of Myo-Inositol 1-Phosphate Synthase From Saccharomyces cerevisiae In Complex With NAD+ and 2-deoxy-D-glucitol 6-(E)-vinylhomophosphonate | Descriptor: | (3,4,5,7-TETRAHYDROXY-HEPT-1-ENYL)-PHOSPHONIC ACID, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | Authors: | Jin, X, Foley, K.M, Geiger, J.H. | Deposit date: | 2003-11-26 | Release date: | 2004-05-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | The structure of the 1L-myo-inositol-1-phosphate synthase-NAD+-2-deoxy-D-glucitol 6-(E)-vinylhomophosphonate complex demands a revision of the enzyme mechanism. J.Biol.Chem., 279, 2004
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