7BM3
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![BU of 7bm3 by Molmil](/molmil-images/mine/7bm3) | Notum Rosmarinic acid complex | Descriptor: | (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhao, Y, Jones, E.Y. | Deposit date: | 2021-01-19 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Notum Inhibitor To Be Published
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6WJO
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![BU of 6wjo by Molmil](/molmil-images/mine/6wjo) | Crystal structure of wild-type Arginine Repressor from the pathogenic bacterium Corynebacterium pseudotuberculosis bound to tyrosine | Descriptor: | Arginine repressor, SODIUM ION, SULFATE ION, ... | Authors: | Nascimento, A.F.Z, Hernandez-Gonzalez, J.E, de Morais, M.A.B, Murakami, M.T, Carareto, C.M.A, Arni, R.K, Mariutti, R.B. | Deposit date: | 2020-04-14 | Release date: | 2020-04-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.693 Å) | Cite: | A single P115Q mutation modulates specificity in the Corynebacterium pseudotuberculosis arginine repressor. Biochim Biophys Acta Gen Subj, 1864, 2020
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6WJR
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2YVQ
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![BU of 2yvq by Molmil](/molmil-images/mine/2yvq) | Crystal structure of MGS domain of carbamoyl-phosphate synthetase from homo sapiens | Descriptor: | Carbamoyl-phosphate synthase | Authors: | Xie, Y, Ihsanawati, Kishishita, S, Murayama, K, Takemoto, C, Shirozu, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-13 | Release date: | 2008-04-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Crystal structure of MGS domain of carbamoyl-phosphate synthetase from homo sapiens To be Published
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6WK2
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![BU of 6wk2 by Molmil](/molmil-images/mine/6wk2) | SETD3 mutant (N255V) in Complex with an Actin Peptide with His73 Replaced with Methionine | Descriptor: | 1,2-ETHANEDIOL, Actin, cytoplasmic 2, ... | Authors: | Dai, S, Horton, J.R, Cheng, X. | Deposit date: | 2020-04-15 | Release date: | 2020-06-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Characterization of SETD3 methyltransferase-mediated protein methionine methylation. J.Biol.Chem., 295, 2020
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6WKH
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![BU of 6wkh by Molmil](/molmil-images/mine/6wkh) | Crystal structure of pentalenene synthase mutant F76W complexed with 12,13-difluorofarnesyl diphosphate | Descriptor: | (2E,6E)-12-fluoro-11-(fluoromethyl)-3,7-dimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate, Pentalenene synthase | Authors: | Prem Kumar, R, Matos, J.O, Oprian, D.D. | Deposit date: | 2020-04-16 | Release date: | 2020-08-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase. Biochemistry, 59, 2020
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2YY9
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![BU of 2yy9 by Molmil](/molmil-images/mine/2yy9) | Crystal structure of BTB domain from mouse HKR3 | Descriptor: | Zinc finger and BTB domain-containing protein 48 | Authors: | Kishishita, S, Nishino, A, Murayama, K, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-27 | Release date: | 2008-04-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of BTB domain from mouse HKR3 To be Published
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6WVD
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![BU of 6wvd by Molmil](/molmil-images/mine/6wvd) | Human JAGN1 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Green fluorescent protein, Protein jagunal homolog 1 chimera | Authors: | Yang, Y, Liu, S, Li, W. | Deposit date: | 2020-05-05 | Release date: | 2021-01-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Termini restraining of small membrane proteins enables structure determination at near-atomic resolution. Sci Adv, 6, 2020
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6WVN
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![BU of 6wvn by Molmil](/molmil-images/mine/6wvn) | Crystal Structure of Nsp16-Nsp10 from SARS-CoV-2 in Complex with 7-methyl-GpppA and S-Adenosylmethionine. | Descriptor: | 2'-O-methyltransferase, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, ADENINE, ... | Authors: | Minasov, G, Shuvalova, L, Rosas-Lemus, M, Kiryukhina, O, Brunzelle, J.S, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-05-06 | Release date: | 2020-05-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | High-resolution structures of the SARS-CoV-2 2'- O -methyltransferase reveal strategies for structure-based inhibitor design. Sci.Signal., 13, 2020
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2YZ2
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![BU of 2yz2 by Molmil](/molmil-images/mine/2yz2) | Crystal structure of the ABC transporter in the cobalt transport system | Descriptor: | Putative ABC transporter ATP-binding protein TM_0222 | Authors: | Ethayathullah, A.S, Bessho, Y, Padmanabhan, B, Singh, T.P, Kaur, P, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-02 | Release date: | 2007-11-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the ABC transporter in the cobalt transport system To be Published
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6WWD
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8SIV
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![BU of 8siv by Molmil](/molmil-images/mine/8siv) | Structure of Compound 2 bound to the CHK1 10-point mutant | Descriptor: | N-(7-chloro-6-{1-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperidin-4-yl}isoquinolin-3-yl)cyclopropanecarboxamide, Serine/threonine-protein kinase Chk1 | Authors: | Palte, R.L. | Deposit date: | 2023-04-17 | Release date: | 2023-11-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.759 Å) | Cite: | Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease. J.Med.Chem., 66, 2023
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2YZQ
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![BU of 2yzq by Molmil](/molmil-images/mine/2yzq) | Crystal structure of uncharacterized conserved protein from Pyrococcus horikoshii | Descriptor: | Putative uncharacterized protein PH1780, S-ADENOSYLMETHIONINE | Authors: | Kanagawa, M, Minami, Y, Watanabe, N, Yokoyama, S, Kuramitsu, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-06 | Release date: | 2007-11-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Crystal structure of uncharacterized conserved protein from Pyrococcus horikoshii To be Published
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6D9I
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2Z0J
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![BU of 2z0j by Molmil](/molmil-images/mine/2z0j) | Crystal structure of uncharacterized conserved protein from Thermus thermophilus HB8 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Putative uncharacterized protein TTHA1438 | Authors: | Nakagawa, N, Kukimoto-Niino, M, Yokoyama, S, Kuramitsu, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-07 | Release date: | 2007-11-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of uncharacterized conserved protein from Thermus thermophilus HB8 To be Published
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6DP1
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6DPF
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4U2T
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2YQP
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![BU of 2yqp by Molmil](/molmil-images/mine/2yqp) | Solution structure of the zf-HIT domain in DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 | Descriptor: | Probable ATP-dependent RNA helicase DDX59, ZINC ION | Authors: | He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Tarada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-03-30 | Release date: | 2007-10-02 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the zf-HIT domain in DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 To be Published
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8SIX
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![BU of 8six by Molmil](/molmil-images/mine/8six) | Structure of Compound 13 bound to the CHK1 10-point mutant | Descriptor: | (1S)-N-(7-chloro-6-{4-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperazin-1-yl}isoquinolin-3-yl)-6-oxaspiro[2.5]octane-1-carboxamide, Serine/threonine-protein kinase Chk1 | Authors: | Palte, R.L. | Deposit date: | 2023-04-17 | Release date: | 2023-11-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease. J.Med.Chem., 66, 2023
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2YR6
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![BU of 2yr6 by Molmil](/molmil-images/mine/2yr6) | Crystal structure of L-phenylalanine oxidase from Psuedomonas sp.P501 | Descriptor: | 2-AMINOBENZOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Ida, K, Kurabayashi, M, Suguro, M, Suzuki, H. | Deposit date: | 2007-04-02 | Release date: | 2008-04-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural basis of proteolytic activation of L-phenylalanine oxidase from Pseudomonas sp. P-501. J.Biol.Chem., 283, 2008
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2YS4
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![BU of 2ys4 by Molmil](/molmil-images/mine/2ys4) | Solution structure of the N-terminal PapD-like domain of HYDIN protein from human | Descriptor: | Hydrocephalus-inducing protein homolog | Authors: | Li, H, Tomizawa, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-03 | Release date: | 2008-04-08 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the N-terminal PapD-like domain of HYDIN protein from human To be Published
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2Y9J
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2YT1
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![BU of 2yt1 by Molmil](/molmil-images/mine/2yt1) | Solution structure of the chimera of the C-terminal tail peptide of APP and the C-terminal PID domain of Fe65L | Descriptor: | Amyloid beta A4 protein and Amyloid beta A4 precursor protein-binding family B member 2 | Authors: | Li, H, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-05 | Release date: | 2008-04-08 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode J.Biol.Chem., 283, 2008
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8SIW
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![BU of 8siw by Molmil](/molmil-images/mine/8siw) | Structure of Compound 5 bound to the CHK1 10-point mutant | Descriptor: | (1S,2S)-N-(7-chloro-6-{1-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperidin-4-yl}isoquinolin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)cyclopropane-1-carboxamide, Serine/threonine-protein kinase Chk1 | Authors: | Palte, R.L. | Deposit date: | 2023-04-17 | Release date: | 2023-11-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.877 Å) | Cite: | Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease. J.Med.Chem., 66, 2023
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