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1CTW	T4 LYSOZYME MUTANT I78A Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Gassner, N.C, Baase, W.A, Lindstrom, J.D, Lu, J, Matthews, B.W. Deposit date: 1999-08-20 Release date: 1999-11-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding. Biochemistry, 38, 1999
1CU5	T4 LYSOZYME MUTANT L91M Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Gassner, N.C, Baase, W.A, Lindstrom, J.D, Lu, J, Matthews, B.W. Deposit date: 1999-08-20 Release date: 1999-11-10 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding. Biochemistry, 38, 1999
1CV6	T4 LYSOZYME MUTANT V149M Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Gassner, N.C, Baase, W.A, Lindstrom, J, Lu, J, Matthews, B.W. Deposit date: 1999-08-22 Release date: 1999-11-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding. Biochemistry, 38, 1999
1D2W	N-TERMINAL DOMAIN CORE METHIONINE MUTATION Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Gassner, N.C, Matthews, B.W. Deposit date: 1999-09-28 Release date: 1999-10-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Use of differentially substituted selenomethionine proteins in X-ray structure determination. Acta Crystallogr.,Sect.D, 55, 1999
1D2Y	N-TERMINAL DOMAIN CORE METHIONINE MUTATION Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Gassner, N.C, Matthews, B.W. Deposit date: 1999-09-28 Release date: 1999-10-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Use of differentially substituted selenomethionine proteins in X-ray structure determination. Acta Crystallogr.,Sect.D, 55, 1999
1CX6	T4 LYSOZYME SUBSTITUTED WITH SELENOMETHIONINE Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Gassner, N.C, Baase, W.A, Matthews, B.W. Deposit date: 1999-08-28 Release date: 1999-12-15 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Substitution with selenomethionine can enhance the stability of methionine-rich proteins. J.Mol.Biol., 294, 1999
1JTN	Alternative Structures of a Sequence Extended T4 Lysozyme Show that the Highly Conserved Beta-Sheet Region has weak intrinsic Folding Propensity Descriptor: LYSOZYME, SULFATE ION Authors: Sagermann, M, Matthews, B.W. Deposit date: 2001-08-21 Release date: 2002-03-20 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structures of a T4-lysozyme Duplication-extension Mutant Demonstrate that the Highly Conserved beta-Sheet Region has Low Intrinsic Folding Propensity J.Mol.Biol., 316, 2002
1JTM	Alternative Structures of a Sequence Extended T4 Lysozyme Show that the Highly Conserved Beta-Sheet has Weak Intrinsic Folding Propensity Descriptor: BETA-MERCAPTOETHANOL, LYSOZYME Authors: Sagermann, M, Matthews, B.W. Deposit date: 2001-08-21 Release date: 2002-03-20 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structures of a T4-lysozyme Duplication-extension Mutant Demonstrate that the Highly Conserved beta-Sheet Region has Low Intrinsic Folding Propensity J.Mol.Biol., 316, 2002
1I6S	T4 LYSOZYME MUTANT C54T/C97A/N101A Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Kovall, R.A, Baldwin, E.P, Matthews, B.W. Deposit date: 2001-03-04 Release date: 2001-05-09 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and thermodynamic analysis of the binding of solvent at internal sites in T4 lysozyme. Protein Sci., 10, 2001
1KW7	METHIONINE CORE MUTANT OF T4 LYSOZYME Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Gassner, N.C, Baase, W.A, Mooers, B.H, Busam, R.D, Weaver, L.H, Lindstrom, J.D, Quillin, M.L, Matthews, B.W. Deposit date: 2002-01-28 Release date: 2003-06-03 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability BIOPHYS.CHEM., 100, 2003
1KS3	METHIONINE CORE MUTANT OF T4 LYSOZYME Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Gassner, N.C, Baase, W.A, Mooers, B.H, Busam, R.D, Weaver, L.H, Lindstrom, J.D, Quillin, M.L, Matthews, B.W. Deposit date: 2002-01-10 Release date: 2003-06-03 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability BIOPHYS.CHEM., 100, 2003
1KW5	METHIONINE CORE MUTANT OF T4 LYSOZYME Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME Authors: Gassner, N.C, Baase, W.A, Mooers, B.H, Busam, R.D, Weaver, L.H, Lindstrom, J.D, Quillin, M.L, Matthews, B.W. Deposit date: 2002-01-28 Release date: 2003-06-03 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability BIOPHYS.CHEM., 100, 2003
1JQU	Are Carboxy Terminii of Helices Coded by the Local Sequence or by Tertiary Structure Contacts Descriptor: Lysozyme Authors: Sagermann, M, Martensson, L.-G, Baase, W.A, Matthews, B.W. Deposit date: 2001-08-08 Release date: 2002-03-06 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A test of proposed rules for helix capping: Implications for protein design Protein Sci., 11, 2002
1L02	CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Dao-Pin, S, Alber, T, Matthews, B.W. Deposit date: 1988-02-05 Release date: 1988-04-16 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme. Nature, 330, 1987
1L09	CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Dao-Pin, S, Bell, J, Alber, T, Matthews, B.W. Deposit date: 1988-02-05 Release date: 1988-04-16 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme. Nature, 330, 1987
1L26	REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY Descriptor: BETA-MERCAPTOETHANOL, T4 LYSOZYME Authors: Bell, J.A, Dao-Pin, S, Matthews, B.W. Deposit date: 1989-05-01 Release date: 1990-01-15 Last modified: 2022-11-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Replacements of Pro86 in phage T4 lysozyme extend an alpha-helix but do not alter protein stability. Science, 239, 1988
1L44	CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY Descriptor: T4 LYSOZYME Authors: Daopin, S, Matthews, B.W. Deposit date: 1991-01-28 Release date: 1991-10-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability. J.Mol.Biol., 221, 1991
1L58	ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, T4 LYSOZYME Authors: Nicholson, H, Matthews, B.W. Deposit date: 1991-05-06 Release date: 1991-10-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.65 Å) Cite: To be Published
1L64	TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Heinz, D, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Folding and function of a T4 lysozyme containing 10 consecutive alanines illustrate the redundancy of information in an amino acid sequence. Proc.Natl.Acad.Sci.USA, 89, 1992
1L71	MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Zhang, X, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992
1L76	TOLERANCE OF T4 LYSOZYME TO PROLINE SUBSTITUTIONS WITHIN THE LONG INTERDOMAIN ALPHA-HELIX ILLUSTRATES THE ADAPTABILITY OF PROTEINS TO POTENTIALLY DESTABILIZING LESIONS Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Sauer, U, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions. J.Biol.Chem., 267, 1992
1L91	SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Eriksson, A.E, Matthews, B.W. Deposit date: 1992-01-21 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J.Mol.Biol., 229, 1993
1L96	STRUCTURE OF A HINGE-BENDING BACTERIOPHAGE T4 LYSOZYME MUTANT, ILE3-> PRO Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Dixon, M, Shewchuk, L, Matthews, B.W. Deposit date: 1992-02-11 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of a hinge-bending bacteriophage T4 lysozyme mutant, Ile3-->Pro. J.Mol.Biol., 227, 1992
1LGW	T4 Lysozyme Mutant L99A/M102Q Bound by 2-fluoroaniline Descriptor: 2-FLUOROANILINE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... Authors: Wei, B.Q, Baase, W.A, Weaver, L.H, Matthews, B.W, Shoichet, B.K. Deposit date: 2002-04-16 Release date: 2002-05-08 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.85 Å) Cite: A Model Binding Site for Testing Scoring Functions in Molecular Docking J.Mol.Biol., 322, 2002
1KNI	Stabilizing Disulfide Bridge Mutant of T4 Lysozyme Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Jacobson, R.H, Matsumura, M, Faber, H.R, Matthews, B.W. Deposit date: 2001-12-18 Release date: 2001-12-28 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure of a stabilizing disulfide bridge mutant that closes the active-site cleft of T4 lysozyme. Protein Sci., 1, 1992

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