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3T1U	Crystal Structure of the complex of Cyclophilin-A enzyme from Azotobacter vinelandii with sucAFPFpNA peptide Descriptor: Peptidyl-prolyl cis-trans isomerase, succinyl-Ala-Phe-Pro-Phe-p-nitroanilide Authors: Karpusas, M, Christoforides, E, Bethanis, K, Dimou, M, Katinakis, P. Deposit date: 2011-07-22 Release date: 2012-03-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of a bacterial cytoplasmic cyclophilin A in complex with a tetrapeptide. Acta Crystallogr.,Sect.F, 68, 2012
7L6Y	Crystal Structure of the Peptidyl-Prolyl Cis-Trans Isomerase (PpiB) from Streptococcus pyogenes. Descriptor: Peptidyl-prolyl cis-trans isomerase Authors: Minasov, G, Shuvalova, L, Kiryukhina, O, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2020-12-24 Release date: 2021-12-01 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Crystal Structure of the Peptidyl-Prolyl Cis-Trans Isomerase (PpiB) from Streptococcus pyogenes. To Be Published
7L6Z	Crystal Structure of Peptidyl-Prolyl Cis-Trans Isomerasefrom (PpiB) Streptococcus pneumoniae R6 Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... Authors: Minasov, G, Shuvalova, L, Kiryukhina, O, Dubrovska, I, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2020-12-24 Release date: 2021-12-01 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Crystal Structure of Peptidyl-Prolyl Cis-Trans Isomerasefrom (PpiB) Streptococcus pneumoniae R6 To Be Published
7TGV	Structure of Cyclophilin D Peptidyl-Prolyl Isomerase Domain bound to Macrocyclic Inhibitor B2 Descriptor: (4S,7S,11R,13E,19S)-N-[2-(2-aminoethoxy)ethyl]-7-benzyl-4-[([1,1'-biphenyl]-4-yl)methyl]-3,6,12,15,21-pentaoxo-1,3,4,5,6,7,8,9,10,12,15,16,17,18,19,20,21,22-octadecahydro-2H-7,11-methano-2,5,11,16,20-benzopentaazacyclotetracosine-19-carboxamide, Peptidyl-prolyl cis-trans isomerase F, mitochondrial Authors: Rangwala, A.M, Thakur, M.K, Seeliger, M.A, Peterson, A.A, Liu, D.R. Deposit date: 2022-01-09 Release date: 2022-08-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat.Chem.Biol., 18, 2022
7TGS	Structure of Cyclophilin D Peptidyl-Prolyl Isomerase Domain bound to Macrocyclic Inhibitor JOMBt Descriptor: (4S,7R,11S,13E,19S)-N-[2-(2-aminoethoxy)ethyl]-4-[(furan-2-yl)methyl]-3,6,12,15,21-pentaoxo-1,3,4,5,6,7,8,9,10,12,15,16,17,18,19,20,21,22-octadecahydro-2H-7,11-methano-2,5,11,16,20-benzopentaazacyclotetracosine-19-carboxamide, Peptidyl-prolyl cis-trans isomerase F, mitochondrial Authors: Rangwala, A.M, Seeliger, M.A, Peterson, A.A, Liu, D.R. Deposit date: 2022-01-09 Release date: 2022-08-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat.Chem.Biol., 18, 2022
7TGU	Structure of Cyclophilin D Peptidyl-Prolyl Isomerase Domain bound to Macrocyclic Inhibitor B1 Descriptor: (4S,7S,11R,13E,19S)-N-[2-(2-aminoethoxy)ethyl]-4-[(4-benzoylphenyl)methyl]-7-benzyl-3,6,12,15,21-pentaoxo-1,3,4,5,6,7,8,9,10,12,15,16,17,18,19,20,21,22-octadecahydro-2H-7,11-methano-2,5,11,16,20-benzopentaazacyclotetracosine-19-carboxamide, Peptidyl-prolyl cis-trans isomerase F, mitochondrial Authors: Rangwala, A.M, Thakur, M.K, Seeliger, M.A, Peterson, A.A, Liu, D.R. Deposit date: 2022-01-09 Release date: 2022-08-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.21 Å) Cite: Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat.Chem.Biol., 18, 2022
7TGT	Structure of Cyclophilin D Peptidyl-Prolyl Isomerase Domain bound to Macrocyclic Inhibitor A26 Descriptor: (4S,7S,11R,13E,19S)-N-[2-(2-aminoethoxy)ethyl]-7-benzyl-4-[(furan-2-yl)methyl]-3,6,12,15,21-pentaoxo-1,3,4,5,6,7,8,9,10,12,15,16,17,18,19,20,21,22-octadecahydro-2H-7,11-methano-2,5,11,16,20-benzopentaazacyclotetracosine-19-carboxamide, Peptidyl-prolyl cis-trans isomerase F, mitochondrial Authors: Rangwala, A.M, Seeliger, M.A, Peterson, A.A, Liu, D.R. Deposit date: 2022-01-09 Release date: 2022-08-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.06 Å) Cite: Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat.Chem.Biol., 18, 2022
6U5C	RT XFEL structure of CypA solved using MESH injection system Descriptor: Peptidyl-prolyl cis-trans isomerase A Authors: Wolff, A.M, Thompson, M.C. Deposit date: 2019-08-27 Release date: 2020-01-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals Iucrj, 7, 2020
3BO7	Crystal structure of Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, 541.m00136 Descriptor: 1,2-ETHANEDIOL, CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE CYCLOPHILIN-TYPE, ... Authors: Wernimont, A.K, Lew, J, Kozieradzki, I, Lin, Y.H, Sun, X, Khuu, C, Zhao, Y, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bochkarev, A, Hui, R, Artz, J.D, Xiao, T, Structural Genomics Consortium (SGC) Deposit date: 2007-12-17 Release date: 2008-02-19 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Crystal Structure of Toxoplasma Gondii Peptidyl-Prolyl Cis-Trans Isomerase, 541.M00136. To be Published
6U5E	RT XFEL structure of CypA solved using celloluse carrier media Descriptor: Peptidyl-prolyl cis-trans isomerase A Authors: Wolff, A.M, Nango, E, Nakane, T, Young, I.D, Brewster, A.S, Sugahara, M, Tanaka, R, Sauter, N.K, Tono, K, Iwata, S, Fraser, J.S, Thompson, M.C. Deposit date: 2019-08-27 Release date: 2020-01-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals Iucrj, 7, 2020
6U5G	MicroED structure of a FIB-milled CypA Crystal Descriptor: Peptidyl-prolyl cis-trans isomerase A Authors: Wolff, A.M, Martynowycz, M.W, Zhao, W, Gonen, T, Fraser, J.S, Thompson, M.C. Deposit date: 2019-08-27 Release date: 2020-01-29 Last modified: 2023-10-11 Method: ELECTRON CRYSTALLOGRAPHY (2.5 Å) Cite: Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals Iucrj, 7, 2020
6U5D	RT XFEL structure of CypA solved using LCP injection system Descriptor: Peptidyl-prolyl cis-trans isomerase A Authors: Wolff, A.M, Young, I.D, Sierra, R.G, Brewster, A.S, Koralek, J.D, Boutet, S, Sauter, N.K, Fraser, J.S, Thompson, M.C. Deposit date: 2019-08-27 Release date: 2020-01-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals Iucrj, 7, 2020
3BT8	Crystal Structure of Mutant Cyclophilin (R147A) from Leishmania donovani Descriptor: Peptidyl-prolyl cis-trans isomerase Authors: Venugopal, V, Sen, B, Datta, A.K, Banerjee, R. Deposit date: 2007-12-28 Release date: 2008-01-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal Structure of Mutant Cyclophilin from Leishmania Donovani To be Published
7N3J	E. coli peptidyl-prolyl cis-trans isomerase, mutant Phe27CF3-Tyr/Phe98CF3-Tyr Descriptor: Peptidyl-prolyl cis-trans isomerase B Authors: Frkic, R.L, Otting, G, Jackson, C.J. Deposit date: 2021-06-01 Release date: 2021-09-29 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Through-Space Scalar 19 F- 19 F Couplings between Fluorinated Noncanonical Amino Acids for the Detection of Specific Contacts in Proteins. J.Am.Chem.Soc., 143, 2021
3CYH	CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE SER-PRO Descriptor: CYCLOPHILIN A, PROLINE, SERINE Authors: Zhao, Y, Ke, H. Deposit date: 1996-02-27 Release date: 1996-07-11 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mechanistic implication of crystal structures of the cyclophilin-dipeptide complexes. Biochemistry, 35, 1996
3CYS	DETERMINATION OF THE NMR SOLUTION STRUCTURE OF THE CYCLOPHILIN A-CYCLOSPORIN A COMPLEX Descriptor: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A Authors: Spitzfaden, C, Braun, W, Wider, G, Widmer, H, Wuthrich, K. Deposit date: 1994-02-28 Release date: 1994-08-31 Last modified: 2017-11-01 Method: SOLUTION NMR Cite: Determination of the NMR Solution Structure of the Cyclophilin A-Cyclosporin a Complex. J.Biomol.NMR, 4, 1994
5EX1	Crystal structure of cyclophilin AquaCyp300 from Hirschia baltica Descriptor: MAGNESIUM ION, Peptidyl-prolyl cis-trans isomerase cyclophilin type Authors: Jakob, R.P, Maier, T. Deposit date: 2015-11-23 Release date: 2016-06-22 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.053 Å) Cite: Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps. Plos One, 11, 2016
5EX2	Crystal structure of cyclophilin AquaCyp293 from Hirschia baltica Descriptor: CALCIUM ION, CHLORIDE ION, MAGNESIUM ION, ... Authors: Jakob, R.P, Maier, T. Deposit date: 2015-11-23 Release date: 2016-06-22 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.294 Å) Cite: Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps. Plos One, 11, 2016
1OCA	HUMAN CYCLOPHILIN A, UNLIGATED, NMR, 20 STRUCTURES Descriptor: CYCLOPHILIN A Authors: Ottiger, M, Zerbe, O, Guntert, P, Wuthrich, K. Deposit date: 1997-07-07 Release date: 1997-11-19 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: The NMR solution conformation of unligated human cyclophilin A. J.Mol.Biol., 272, 1997
5F66	High-resolution isotropic multiconformer synchrotron model of CypA at 273 K Descriptor: Peptidyl-prolyl cis-trans isomerase A Authors: Fraser, J.S. Deposit date: 2015-12-05 Release date: 2015-12-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Measuring and modeling diffuse scattering in protein X-ray crystallography. Proc.Natl.Acad.Sci.USA, 113, 2016
1QNH	Plasmodium falciparum Cyclophilin (double mutant) complexed with Cyclosporin A Descriptor: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE Authors: Peterson, M.R, Hall, D.R, Hunter, W.N. Deposit date: 1999-10-14 Release date: 2000-10-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The Three-Dimensional Structure of a Plasmodium Falciparum Cyclophilin in Complex with the Potent Anti-Malarial Cyclosporin A J.Mol.Biol., 298, 2000
5T9U	Discovery of a Potent Cyclophilin Inhibitor (Compound 3) based on Structural Simplification of Sanglifehrin A Descriptor: 3-[(3-hydroxyphenyl)methyl]-10,12-dimethoxy-9,11-dimethyl-6-(propan-2-yl)-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetrone, Peptidyl-prolyl cis-trans isomerase A Authors: Appleby, T.C, Steadman, V, Pettit, S, Schmitz, U, Mackman, R.L, Schultz, B. Deposit date: 2016-09-09 Release date: 2017-01-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.301 Å) Cite: Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A. J. Med. Chem., 60, 2017
5T9Z	Discovery of a Potent Cyclophilin Inhibitor (Compound 6) based on Structural Simplification of Sanglifehrin A Descriptor: 11-[(3-hydroxyphenyl)methyl]-18-methoxy-17-methyl-14-(propan-2-yl)-3-oxa-9,12,15,28-tetraazatricyclo[21.3.1.1~5,9~]octacosa-1(27),21,23,25-tetraene-4,10,13,16-tetrone, Peptidyl-prolyl cis-trans isomerase A Authors: Appleby, T.C, Steadman, V, Pettit, S, Schmitz, U, Mackman, R.L, Schultz, B. Deposit date: 2016-09-09 Release date: 2017-01-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A. J. Med. Chem., 60, 2017
1QOI	U4/U6 snRNP-specific cyclophilin SnuCyp-20 Descriptor: SNUCYP-20 Authors: Reidt, U, Reuter, K, Achsel, T, Ingelfinger, D, Luehrmann, R, Ficner, R. Deposit date: 1999-11-09 Release date: 2000-04-10 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of the Human U4/U6 Small Nuclear Ribonucleoproteinparticle-Specificsnucyp-20, a Nuclear Cyclophilin J.Biol.Chem., 275, 2000
1QNG	Plasmodium falciparum Cyclophilin complexed with Cyclosporin A Descriptor: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE Authors: Peterson, M.R, Hall, D.R, Hunter, W.N. Deposit date: 1999-10-14 Release date: 2000-10-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The Three-Dimensional Structure of a Plasmodium Falciparum Cyclophilin in Complex with the Potent Anti-Malarial Cyclosporin A J.Mol.Biol., 298, 2000

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