6DZK
| Cryo-EM Structure of Mycobacterium smegmatis C(minus) 30S ribosomal subunit with MPY | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Sharma, M.R, Li, Y, Korripella, R, Yang, Y, Kaushal, P.S, Lin, Q, Wade, J.T, Gray, A.G, Derbyshire, K.M, Agrawal, R.K, Ojha, A. | Deposit date: | 2018-07-05 | Release date: | 2018-09-19 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Zinc depletion induces ribosome hibernation in mycobacteria. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6DZI
| Cryo-EM Structure of Mycobacterium smegmatis 70S C(minus) ribosome 70S-MPY complex | Descriptor: | 16S rRNA, 23 S rRNA (3119-MER), 30S ribosomal protein S10, ... | Authors: | Sharma, M.R, Li, Y, Korripella, R, Yang, Y, Kaushal, P.S, Lin, Q, Wade, J.T, Gray, A.G, Derbyshire, K.M, Agrawal, R.K, Ojha, A. | Deposit date: | 2018-07-05 | Release date: | 2018-09-26 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Zinc depletion induces ribosome hibernation in mycobacteria. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6GWT
| Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State I) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Graf, M, Huter, P, Maracci, C, Peterek, M, Rodnina, M.V, Wilson, D.N. | Deposit date: | 2018-06-25 | Release date: | 2018-08-15 | Last modified: | 2019-02-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1. Nat Commun, 9, 2018
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6GZX
| T. thermophilus hibernating 100S ribosome (ice) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Flygaard, R.K, Jenner, L.B. | Deposit date: | 2018-07-05 | Release date: | 2018-10-24 | Method: | ELECTRON MICROSCOPY (4.57 Å) | Cite: | Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism. Nat Commun, 9, 2018
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8JDK
| Structure of the Human cytoplasmic Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU) | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | Deposit date: | 2023-05-14 | Release date: | 2023-12-06 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (2.26 Å) | Cite: | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell, 186, 2023
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6GZQ
| T. thermophilus hibernating 70S ribosome | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Flygaard, R.K, Jenner, L.B. | Deposit date: | 2018-07-04 | Release date: | 2018-10-24 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism. Nat Commun, 9, 2018
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6EML
| Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae | Descriptor: | 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, 40S ribosomal protein S11-A, ... | Authors: | Heuer, A, Thomson, E, Schmidt, C, Berninghausen, O, Becker, T, Hurt, E, Beckmann, R. | Deposit date: | 2017-10-02 | Release date: | 2017-11-29 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of a late pre-40S ribosomal subunit fromSaccharomyces cerevisiae. Elife, 6, 2017
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6ENF
| Cryo-EM structure of a polyproline-stalled ribosome in the absence of EF-P | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Huter, P, Arenz, S, Wilson, D.N. | Deposit date: | 2017-10-04 | Release date: | 2017-11-22 | Last modified: | 2018-01-31 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P. Mol. Cell, 68, 2017
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6GQV
| Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP) | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Pellegrino, S, Yusupov, M, Yusupova, G, Hashem, Y. | Deposit date: | 2018-06-08 | Release date: | 2018-07-11 | Last modified: | 2018-08-08 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance. J. Mol. Biol., 430, 2018
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8K4E
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6G5I
| Cryo-EM structure of a late human pre-40S ribosomal subunit - State R | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Ameismeier, M, Cheng, J, Berninghausen, O, Beckmann, R. | Deposit date: | 2018-03-29 | Release date: | 2018-06-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Visualizing late states of human 40S ribosomal subunit maturation. Nature, 558, 2018
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8K3O
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8K2C
| Cryo-EM structure of the human 80S ribosome with Tigecycline | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | Authors: | Li, X, Wang, M, Cheng, J. | Deposit date: | 2023-07-12 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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8K2D
| Cryo-EM structure of the yeast 80S ribosome with tigecycline, eEF2, Stm1 and eIF5A | Descriptor: | 18S rRNA, 23S rRNA, 40S ribosomal protein S1-A, ... | Authors: | Buschauer, R, Beckmann, R, Cheng, J. | Deposit date: | 2023-07-12 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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8K82
| Cryo-EM structure of the yeast 80S ribosome with tigecycline, Not5 and P-site tRNA | Descriptor: | 18S rRNA, 23S rRNA, 40S ribosomal protein S1-A, ... | Authors: | Buschauer, R, Beckmann, R, Cheng, J. | Deposit date: | 2023-07-28 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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6GXN
| Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State III) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Graf, M, Huter, P, Maracci, C, Peterek, M, Rodnina, M.V, Wilson, D.N. | Deposit date: | 2018-06-27 | Release date: | 2018-08-15 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1. Nat Commun, 9, 2018
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6GZ3
| tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-1 (TI-POST-1) | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Flis, J, Holm, M, Rundlet, E.J, Loerke, J, Hilal, T, Dabrowski, M, Buerger, J, Mielke, T, Blanchard, S.C, Spahn, C.M.T, Budkevich, T.V. | Deposit date: | 2018-07-03 | Release date: | 2018-12-05 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis. Cell Rep, 25, 2018
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6H58
| Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - Full 100S Hibernating E. coli Ribosome | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ... | Authors: | Beckert, B, Turk, M, Czech, A, Berninghausen, O, Beckmann, R, Ignatova, Z, Plitzko, J, Wilson, D.N. | Deposit date: | 2018-07-24 | Release date: | 2018-09-05 | Last modified: | 2018-10-24 | Method: | ELECTRON MICROSCOPY (7.9 Å) | Cite: | Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1. Nat Microbiol, 3, 2018
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8P18
| E167K RF2 on E. coli 70S release complex with UGG (Structure III) | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | Authors: | Pundir, S, Larsson, D.S.D, Selmer, M, Sanyal, S. | Deposit date: | 2023-05-11 | Release date: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | The compensatory mechanism of a naturally evolved
E167K RF2 counteracting the loss of
RF1 in bacteria To Be Published
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6GSJ
| Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Rozov, A, Yusupov, M, Yusupova, G. | Deposit date: | 2018-06-14 | Release date: | 2018-07-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | Tautomeric G•U pairs within the molecular ribosomal grip and fidelity of decoding in bacteria. Nucleic Acids Res., 46, 2018
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8S1U
| YlmH bound to stalled 50S subunits with RqcH and PtRNA | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Paternoga, H, Wilson, D.N. | Deposit date: | 2024-02-16 | Release date: | 2024-06-12 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | A role for the S4-domain containing protein YlmH in ribosome-associated quality control in Bacillus subtilis. Nucleic Acids Res., 52, 2024
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8S1P
| YlmH bound to PtRNA-50S | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Paternoga, H, Dimitrova-Paternoga, L, Wilson, D.N. | Deposit date: | 2024-02-15 | Release date: | 2024-06-12 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (1.96 Å) | Cite: | A role for the S4-domain containing protein YlmH in ribosome-associated quality control in Bacillus subtilis. Nucleic Acids Res., 52, 2024
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4WWW
| Crystal structure of the E. coli ribosome bound to CEM-101 | Descriptor: | (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-{4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl}-4-ethyl-7-fluoro-11-methoxy-3a ,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside, 16S rRNA, 23S rRNA, ... | Authors: | Dunkle, J.A, Zhang, W, Cate, J.H.D, Mankin, A.S. | Deposit date: | 2014-11-12 | Release date: | 2014-12-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis. Antimicrob. Agents Chemother., 54, 2010
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4X64
| Crystal Structure of 30S ribosomal subunit from Thermus thermophilus | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Demirci, H, Chen, J, Choi, J, Soltis, M, Puglisi, J.D. | Deposit date: | 2014-12-06 | Release date: | 2015-11-18 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics. Nat.Struct.Mol.Biol., 23, 2016
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8SYL
| Cryo-EM structure of the Escherichia coli 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs | Descriptor: | (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S ,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | Authors: | Seely, S.M, Gagnon, M.G. | Deposit date: | 2023-05-25 | Release date: | 2023-08-09 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome. Nat Commun, 14, 2023
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