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PDB: 764 results
2O79
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BU of 2o79 by Molmil
T4 lysozyme with C-terminal extension
Descriptor: CHLORIDE ION, GLYCEROL, Lysozyme, ...
Authors:Llinas, M, Crowder, S.M, Echols, N, Alber, T, Marqusee, S.
Deposit date:2006-12-10
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Exploring subdomain cooperativity in T4 lysozyme I: Structural and energetic studies of a circular permutant and protein fragment.
Protein Sci., 16, 2007
3HTB
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BU of 3htb by Molmil
2-propylphenol in complex with T4 lysozyme L99A/M102Q
Descriptor: 2-propylphenol, BETA-MERCAPTOETHANOL, Lysozyme, ...
Authors:Boyce, S.E, Mobley, D.L, Rocklin, G.J, Graves, A.P, Dill, K.A, Shoichet, B.K.
Deposit date:2009-06-11
Release date:2009-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Predicting ligand binding affinity with alchemical free energy methods in a polar model binding site.
J.Mol.Biol., 394, 2009
2OTY
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BU of 2oty by Molmil
1,2-dichlorobenzene in complex with T4 Lysozyme L99A
Descriptor: 1,2-DICHLOROBENZENE, BETA-MERCAPTOETHANOL, Lysozyme, ...
Authors:Graves, A.P, Shoichet, B.K.
Deposit date:2007-02-09
Release date:2007-08-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Predicting absolute ligand binding free energies to a simple model site.
J.Mol.Biol., 371, 2007
3C83
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BU of 3c83 by Molmil
Bacteriophage T4 lysozyme mutant D89A in wildtype background at room temperature
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme
Authors:Mooers, B.H.M.
Deposit date:2008-02-08
Release date:2009-02-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme.
Protein Sci., 18, 2009
2RB0
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BU of 2rb0 by Molmil
2,6-difluorobenzylbromide complex with T4 lysozyme L99A
Descriptor: 2-(bromomethyl)-1,3-difluorobenzene, Lysozyme, PHOSPHATE ION
Authors:Graves, A.P, Boyce, S.E, Shoichet, B.K.
Deposit date:2007-09-17
Release date:2008-03-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Rescoring docking hit lists for model cavity sites: predictions and experimental testing.
J.Mol.Biol., 377, 2008
1QUH
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BU of 1quh by Molmil
L99G/E108V MUTANT OF T4 LYSOZYME
Descriptor: CHLORIDE ION, HEXANE-1,6-DIOL, PROTEIN (LYSOZYME)
Authors:Wray, J, Baase, W.A, Lindstrom, J.D, Poteete, A.R, Matthews, B.W.
Deposit date:1999-07-01
Release date:1999-07-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural analysis of a non-contiguous second-site revertant in T4 lysozyme shows that increasing the rigidity of a protein can enhance its stability.
J.Mol.Biol., 292, 1999
1QS9
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BU of 1qs9 by Molmil
THE INTRODUCTION OF STRAIN AND ITS EFFECTS ON THE STRUCTURE AND STABILITY OF T4 LYSOZYME
Descriptor: LYSOZYME
Authors:Liu, R, Baase, W.A, Matthews, B.W.
Deposit date:1999-06-25
Release date:1999-07-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The introduction of strain and its effects on the structure and stability of T4 lysozyme.
J.Mol.Biol., 295, 2000
1L72
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BU of 1l72 by Molmil
MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
Authors:Zhang, X, Matthews, B.W.
Deposit date:1991-09-23
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability.
Protein Sci., 1, 1992
109L
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BU of 109l by Molmil
STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
Authors:Blaber, M, Matthews, B.W.
Deposit date:1992-12-17
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis of amino acid alpha helix propensity.
Science, 260, 1993
146L
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BU of 146l by Molmil
ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
Authors:Baldwin, E, Matthews, B.W.
Deposit date:1993-10-15
Release date:1994-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The role of backbone flexibility in the accommodation of variants that repack the core of T4 lysozyme.
Science, 262, 1993
125L
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BU of 125l by Molmil
THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
Authors:Blaber, M, Matthews, B.W.
Deposit date:1993-05-28
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Energetic cost and structural consequences of burying a hydroxyl group within the core of a protein determined from Ala-->Ser and Val-->Thr substitutions in T4 lysozyme.
Biochemistry, 32, 1993
127L
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BU of 127l by Molmil
THE ENERGETIC COST AND THE STRUCTURAL CONSEQUENCES OF BURYING A HYDROXYL GROUP WITHIN THE CORE OF A PROTEIN DETERMINED FROM ALA TO SER AND VAL TO THR SUBSTITUTIONS IN T4 LYSOZYME
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
Authors:Blaber, M, Matthews, B.W.
Deposit date:1993-05-28
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Energetic cost and structural consequences of burying a hydroxyl group within the core of a protein determined from Ala-->Ser and Val-->Thr substitutions in T4 lysozyme.
Biochemistry, 32, 1993
137L
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BU of 137l by Molmil
STRUCTURAL BASIS OF AMINO ACID ALPHA HELIX PROPENSITY
Descriptor: T4 LYSOZYME
Authors:Blaber, M, Matthews, B.W.
Deposit date:1993-08-17
Release date:1994-07-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis of amino acid alpha helix propensity.
Science, 260, 1993
3C81
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BU of 3c81 by Molmil
Mutant K85A of T4 lysozyme in wildtype background at room temperature
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme
Authors:Mooers, B.H.M.
Deposit date:2008-02-08
Release date:2009-02-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme.
Protein Sci., 18, 2009
1QT3
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BU of 1qt3 by Molmil
T26D MUTANT OF T4 LYSOZYME
Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, PROTEIN (T4 Lysozyme)
Authors:Kuroki, R, Weaver, L.H, Matthews, B.W.
Deposit date:1999-06-30
Release date:1999-07-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site.
Proc.Natl.Acad.Sci.USA, 96, 1999
3GUK
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BU of 3guk by Molmil
T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--Toluene binding
Descriptor: ACETATE ION, CALCIUM ION, CHLORIDE ION, ...
Authors:Liu, L, Matthews, B.W.
Deposit date:2009-03-30
Release date:2009-08-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Use of stabilizing mutations to engineer a charged group within a ligand-binding hydrophobic cavity in T4 lysozyme.
Biochemistry, 48, 2009
1L88
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BU of 1l88 by Molmil
SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES
Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
Authors:Eriksson, A.E, Matthews, B.W.
Deposit date:1992-01-21
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences.
J.Mol.Biol., 229, 1993
1L39
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BU of 1l39 by Molmil
CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
Descriptor: T4 LYSOZYME
Authors:Daopin, S, Matthews, B.W.
Deposit date:1991-01-28
Release date:1991-10-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis.
Biochemistry, 30, 1991
1L37
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BU of 1l37 by Molmil
CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
Descriptor: T4 LYSOZYME
Authors:Daopin, S, Matthews, B.W.
Deposit date:1991-01-28
Release date:1991-10-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis.
Biochemistry, 30, 1991
1L21
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BU of 1l21 by Molmil
CONTRIBUTIONS OF LEFT-HANDED HELICAL RESIDUES TO THE STRUCTURE AND STABILITY OF BACTERIOPHAGE T4 LYSOZYME
Descriptor: T4 LYSOZYME
Authors:Nicholson, H, Matthews, B.W.
Deposit date:1989-05-01
Release date:1990-01-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Contributions of left-handed helical residues to the structure and stability of bacteriophage T4 lysozyme.
J.Mol.Biol., 210, 1989
1L40
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BU of 1l40 by Molmil
CONTRIBUTIONS OF ENGINEERED SURFACE SALT BRIDGES TO THE STABILITY OF T4 LYSOZYME DETERMINED BY DIRECTED MUTAGENESIS
Descriptor: T4 LYSOZYME
Authors:Daopin, S, Matthews, B.W.
Deposit date:1991-01-28
Release date:1991-10-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis.
Biochemistry, 30, 1991
1L50
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BU of 1l50 by Molmil
STRUCTURAL AND THERMODYNAMIC ANALYSIS OF THE PACKING OF TWO ALPHA-HELICES IN BACTERIOPHAGE T4 LYSOZYME
Descriptor: T4 LYSOZYME
Authors:Daopin, S, Matthews, B.W.
Deposit date:1991-01-28
Release date:1991-10-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and thermodynamic analysis of the packing of two alpha-helices in bacteriophage T4 lysozyme.
J.Mol.Biol., 221, 1991
220L
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BU of 220l by Molmil
GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS
Descriptor: BENZENE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
Authors:Baldwin, E.P, Baase, W.A, Zhang, X.-J, Feher, V, Matthews, B.W.
Deposit date:1997-06-25
Release date:1998-03-18
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Generation of ligand binding sites in T4 lysozyme by deficiency-creating substitutions.
J.Mol.Biol., 277, 1998
1LGW
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BU of 1lgw by Molmil
T4 Lysozyme Mutant L99A/M102Q Bound by 2-fluoroaniline
Descriptor: 2-FLUOROANILINE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
Authors:Wei, B.Q, Baase, W.A, Weaver, L.H, Matthews, B.W, Shoichet, B.K.
Deposit date:2002-04-16
Release date:2002-05-08
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Model Binding Site for Testing Scoring Functions in Molecular Docking
J.Mol.Biol., 322, 2002
1EPY
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BU of 1epy by Molmil
T4 LYSOZYME MUTANT, T21H/C54T/C97A/Q141H/T142H
Descriptor: CHLORIDE ION, COBALT (II) ION, LYSOZYME, ...
Authors:Wray, J.W, Baase, W.A, Ostheimer, G.J, Zhang, X.-J, Matthews, B.W.
Deposit date:2000-03-29
Release date:2000-04-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Use of a non-rigid region in T4 lysozyme to design an adaptable metal-binding site.
Protein Eng., 13, 2000

221716

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