PDB Search results for query - 日本蛋白質結構資料庫

PDB: 27 results

Discovery of VX-509 (Decernotinib): A Potent and Selective Janus kinase (JAK) 3 Inhibitor for the Treatment of Autoimmune Diseases
Descriptor:	N~2~-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-2-methyl-N-(2,2,2-trifluoroethyl)-D-alaninamide, Tyrosine-protein kinase JAK2
Authors:	Ledeboer, M.W, Zuccola, H.J.
Deposit date:	2015-03-17
Release date:	2015-08-12
Last modified:	2016-07-20
Method:	X-RAY DIFFRACTION (2.04 Å)
Cite:	Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases. J.Med.Chem., 58, 2015

Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity
Descriptor:	2-fluoro-6-[(3S)-tetrahydrofuran-3-ylamino]-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide, Heat shock protein HSP 90-alpha
Authors:	Ernst, J.T, Zuccola, H.J.
Deposit date:	2013-11-04
Release date:	2014-01-15
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Correlation between chemotype-dependent binding conformations of HSP90 alpha / beta and isoform selectivity-Implications for the structure-based design of HSP90 alpha / beta selective inhibitors for treating neurodegenerative diseases. Bioorg.Med.Chem.Lett., 24, 2014