2VKD
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![BU of 2vkd by Molmil](/molmil-images/mine/2vkd) | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP-GLC AND MANGANESE ION | Descriptor: | CYTOTOXIN L, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-GLUCOSE | Authors: | Ziegler, M.O.P, Jank, T, Aktories, K, Schulz, G.E. | Deposit date: | 2007-12-18 | Release date: | 2008-03-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Conformational Changes and Reaction of Clostridial Glycosylating Toxins. J.Mol.Biol., 377, 2008
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2VK9
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2VKH
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![BU of 2vkh by Molmil](/molmil-images/mine/2vkh) | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP-GLC AND CALCIUM ION | Descriptor: | CALCIUM ION, CYTOTOXIN L, URIDINE-5'-DIPHOSPHATE-GLUCOSE | Authors: | Ziegler, M.O.P, Jank, T, Aktories, K, Schulz, G.E. | Deposit date: | 2007-12-19 | Release date: | 2008-03-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Conformational Changes and Reaction of Clostridial Glycosylating Toxins. J.Mol.Biol., 377, 2008
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1GZU
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![BU of 1gzu by Molmil](/molmil-images/mine/1gzu) | Crystal Structure of Human Nicotinamide Mononucleotide Adenylyltransferase in Complex with NMN | Descriptor: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE | Authors: | Werner, E, Ziegler, M, Lerner, F, Schweiger, M, Heinemann, U. | Deposit date: | 2002-06-06 | Release date: | 2002-07-05 | Last modified: | 2018-06-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMN. FEBS Lett., 516, 2002
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8R15
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![BU of 8r15 by Molmil](/molmil-images/mine/8r15) | Crystal structure of Fusarium oxysporum NADase I | Descriptor: | GLYCEROL, TNT domain-containing protein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Kallio, J.P, Ferrario, E, Stromland, O, Ziegler, M. | Deposit date: | 2023-11-01 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Evolution of fungal tuberculosis necrotizing toxin (TNT) domain-containing enzymes reveals divergent adaptations to enhance NAD cleavage. Protein Sci., 33, 2024
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8R17
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![BU of 8r17 by Molmil](/molmil-images/mine/8r17) | Crystal structure of Neurospora crassa NADase with modified C-terminus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Conidial surface nicotinamide adenine dinucleotide glycohydrolase,Conidial surface nicotinamide adenine dinucleotide glycohydrolase nadA, ... | Authors: | Kallio, J.P, Ferrario, E, Ziegler, M. | Deposit date: | 2023-11-01 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Evolution of fungal tuberculosis necrotizing toxin (TNT) domain-containing enzymes reveals divergent adaptations to enhance NAD cleavage. Protein Sci., 33, 2024
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8PMS
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![BU of 8pms by Molmil](/molmil-images/mine/8pms) | NADase from Aspergillus fumigatus with replaced C-terminus from Neurospora crassa | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kallio, J.P, Ferrario, E, Stromland, O, Ziegler, M. | Deposit date: | 2023-06-29 | Release date: | 2023-11-15 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Novel Calcium-Binding Motif Stabilizes and Increases the Activity of Aspergillus fumigatus Ecto-NADase. Biochemistry, 62, 2023
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8PMR
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![BU of 8pmr by Molmil](/molmil-images/mine/8pmr) | NADase from Aspergillus fumigatus with mutated calcium binding motif (D219A/E220A) | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kallio, J.P, Ferrario, E, Stromland, O, Ziegler, M. | Deposit date: | 2023-06-29 | Release date: | 2023-11-15 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Novel Calcium-Binding Motif Stabilizes and Increases the Activity of Aspergillus fumigatus Ecto-NADase. Biochemistry, 62, 2023
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6TAC
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![BU of 6tac by Molmil](/molmil-images/mine/6tac) | Human NAMPT deletion mutant in complex with nicotinamide mononucleotide, pyrophosphate, and Mg2+ | Descriptor: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Houry, D, Raasakka, A, Kursula, P, Ziegler, M. | Deposit date: | 2019-10-29 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Identification of structural determinants of NAMPT activity and substrate selectivity To Be Published
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6YGG
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![BU of 6ygg by Molmil](/molmil-images/mine/6ygg) | NADase from Aspergillus fumigatus complexed with a substrate anologue | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, AfNADase, ... | Authors: | Stromland, O, Ziegler, M, Kallio, J.P. | Deposit date: | 2020-03-27 | Release date: | 2020-12-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Discovery of fungal surface NADases predominantly present in pathogenic species. Nat Commun, 12, 2021
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6YGF
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![BU of 6ygf by Molmil](/molmil-images/mine/6ygf) | NADase from Aspergillus fumigatus with trapped reaction products | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, AfNADase, ... | Authors: | Stromland, O, Ziegler, M, Kallio, J.P. | Deposit date: | 2020-03-27 | Release date: | 2020-12-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of fungal surface NADases predominantly present in pathogenic species. Nat Commun, 12, 2021
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6YGE
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![BU of 6yge by Molmil](/molmil-images/mine/6yge) | NADase from Aspergillus fumigatus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, AfNADase, ... | Authors: | Stromland, O, Ziegler, M, Kallio, J.P. | Deposit date: | 2020-03-27 | Release date: | 2020-12-23 | Last modified: | 2021-07-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Discovery of fungal surface NADases predominantly present in pathogenic species. Nat Commun, 12, 2021
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6TA2
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![BU of 6ta2 by Molmil](/molmil-images/mine/6ta2) | Human NAMPT in complex with nicotinic acid mononucleotide and phosphate | Descriptor: | CHLORIDE ION, GLYCEROL, NICOTINATE MONONUCLEOTIDE, ... | Authors: | Houry, D, Raasakka, A, Kursula, P, Ziegler, M. | Deposit date: | 2019-10-29 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Identification of structural determinants of NAMPT activity and substrate selectivity To Be Published
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6TA0
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![BU of 6ta0 by Molmil](/molmil-images/mine/6ta0) | Human NAMPT in complex with nicotinic acid and phosphoribosyl pyrophosphate | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, GLYCEROL, NICOTINIC ACID, ... | Authors: | Houry, D, Raasakka, A, Kursula, P, Ziegler, M. | Deposit date: | 2019-10-29 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Identification of structural determinants of NAMPT activity and substrate selectivity To Be Published
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2V9U
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![BU of 2v9u by Molmil](/molmil-images/mine/2v9u) | Rim domain of main porin from Mycobacteria smegmatis | Descriptor: | MSPA | Authors: | Grueninger, D, Ziegler, M.O.P, Koetter, J.W.A, Treiber, N, Schulze, M.-S, Schulz, G.E. | Deposit date: | 2007-08-27 | Release date: | 2008-01-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Designed Protein-Protein Association. Science, 319, 2008
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2VL8
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![BU of 2vl8 by Molmil](/molmil-images/mine/2vl8) | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP, CASTANOSPERMINE AND CALCIUM ION | Descriptor: | CALCIUM ION, CASTANOSPERMINE, CYTOTOXIN L, ... | Authors: | Jank, T, Ziegler, M.O.P, Schulz, G.E, Aktories, K. | Deposit date: | 2008-01-09 | Release date: | 2008-06-17 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Inhibition of the Glucosyltransferase Activity of Clostridial Rho/Ras-Glucosylating Toxins by Castanospermine. FEBS Lett., 582, 2008
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