2VKD
 
 | | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP-GLC AND MANGANESE ION | | 分子名称: | CYTOTOXIN L, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-GLUCOSE | | 著者 | Ziegler, M.O.P, Jank, T, Aktories, K, Schulz, G.E. | | 登録日 | 2007-12-18 | | 公開日 | 2008-03-18 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Conformational Changes and Reaction of Clostridial Glycosylating Toxins.
J.Mol.Biol., 377, 2008
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2VK9
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2VKH
 | | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP-GLC AND CALCIUM ION | | 分子名称: | CALCIUM ION, CYTOTOXIN L, URIDINE-5'-DIPHOSPHATE-GLUCOSE | | 著者 | Ziegler, M.O.P, Jank, T, Aktories, K, Schulz, G.E. | | 登録日 | 2007-12-19 | | 公開日 | 2008-03-18 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Conformational Changes and Reaction of Clostridial Glycosylating Toxins.
J.Mol.Biol., 377, 2008
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8R15
 | | Crystal structure of Fusarium oxysporum NADase I | | 分子名称: | GLYCEROL, TNT domain-containing protein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Kallio, J.P, Ferrario, E, Stromland, O, Ziegler, M. | | 登録日 | 2023-11-01 | | 公開日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Evolution of fungal tuberculosis necrotizing toxin (TNT) domain-containing enzymes reveals divergent adaptations to enhance NAD cleavage.
Protein Sci., 33, 2024
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8R17
 | | Crystal structure of Neurospora crassa NADase with modified C-terminus | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Conidial surface nicotinamide adenine dinucleotide glycohydrolase,Conidial surface nicotinamide adenine dinucleotide glycohydrolase nadA, ... | | 著者 | Kallio, J.P, Ferrario, E, Ziegler, M. | | 登録日 | 2023-11-01 | | 公開日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Evolution of fungal tuberculosis necrotizing toxin (TNT) domain-containing enzymes reveals divergent adaptations to enhance NAD cleavage.
Protein Sci., 33, 2024
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8PMS
 | | NADase from Aspergillus fumigatus with replaced C-terminus from Neurospora crassa | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Kallio, J.P, Ferrario, E, Stromland, O, Ziegler, M. | | 登録日 | 2023-06-29 | | 公開日 | 2023-11-15 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Novel Calcium-Binding Motif Stabilizes and Increases the Activity of Aspergillus fumigatus Ecto-NADase.
Biochemistry, 62, 2023
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8PMR
 | | NADase from Aspergillus fumigatus with mutated calcium binding motif (D219A/E220A) | | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Kallio, J.P, Ferrario, E, Stromland, O, Ziegler, M. | | 登録日 | 2023-06-29 | | 公開日 | 2023-11-15 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Novel Calcium-Binding Motif Stabilizes and Increases the Activity of Aspergillus fumigatus Ecto-NADase.
Biochemistry, 62, 2023
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6TAC
 | | Human NAMPT deletion mutant in complex with nicotinamide mononucleotide, pyrophosphate, and Mg2+ | | 分子名称: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Houry, D, Raasakka, A, Kursula, P, Ziegler, M. | | 登録日 | 2019-10-29 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Identification of structural determinants of NAMPT activity and substrate selectivity
To Be Published
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6TA2
 | | Human NAMPT in complex with nicotinic acid mononucleotide and phosphate | | 分子名称: | CHLORIDE ION, GLYCEROL, NICOTINATE MONONUCLEOTIDE, ... | | 著者 | Houry, D, Raasakka, A, Kursula, P, Ziegler, M. | | 登録日 | 2019-10-29 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Identification of structural determinants of NAMPT activity and substrate selectivity
To Be Published
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6TA0
 | | Human NAMPT in complex with nicotinic acid and phosphoribosyl pyrophosphate | | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, GLYCEROL, NICOTINIC ACID, ... | | 著者 | Houry, D, Raasakka, A, Kursula, P, Ziegler, M. | | 登録日 | 2019-10-29 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Identification of structural determinants of NAMPT activity and substrate selectivity
To Be Published
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6YGG
 | | NADase from Aspergillus fumigatus complexed with a substrate anologue | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, AfNADase, ... | | 著者 | Stromland, O, Ziegler, M, Kallio, J.P. | | 登録日 | 2020-03-27 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Discovery of fungal surface NADases predominantly present in pathogenic species.
Nat Commun, 12, 2021
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6YGF
 | | NADase from Aspergillus fumigatus with trapped reaction products | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, AfNADase, ... | | 著者 | Stromland, O, Ziegler, M, Kallio, J.P. | | 登録日 | 2020-03-27 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Discovery of fungal surface NADases predominantly present in pathogenic species.
Nat Commun, 12, 2021
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6YGE
 | | NADase from Aspergillus fumigatus | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, AfNADase, ... | | 著者 | Stromland, O, Ziegler, M, Kallio, J.P. | | 登録日 | 2020-03-27 | | 公開日 | 2020-12-23 | | 最終更新日 | 2021-07-07 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Discovery of fungal surface NADases predominantly present in pathogenic species.
Nat Commun, 12, 2021
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1GZU
 | | Crystal Structure of Human Nicotinamide Mononucleotide Adenylyltransferase in Complex with NMN | | 分子名称: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE | | 著者 | Werner, E, Ziegler, M, Lerner, F, Schweiger, M, Heinemann, U. | | 登録日 | 2002-06-06 | | 公開日 | 2002-07-05 | | 最終更新日 | 2018-06-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMN.
FEBS Lett., 516, 2002
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2V9U
 | | Rim domain of main porin from Mycobacteria smegmatis | | 分子名称: | MSPA | | 著者 | Grueninger, D, Ziegler, M.O.P, Koetter, J.W.A, Treiber, N, Schulze, M.-S, Schulz, G.E. | | 登録日 | 2007-08-27 | | 公開日 | 2008-01-15 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Designed Protein-Protein Association.
Science, 319, 2008
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2VL8
 | | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP, CASTANOSPERMINE AND CALCIUM ION | | 分子名称: | CALCIUM ION, CASTANOSPERMINE, CYTOTOXIN L, ... | | 著者 | Jank, T, Ziegler, M.O.P, Schulz, G.E, Aktories, K. | | 登録日 | 2008-01-09 | | 公開日 | 2008-06-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Inhibition of the Glucosyltransferase Activity of Clostridial Rho/Ras-Glucosylating Toxins by Castanospermine.
FEBS Lett., 582, 2008
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