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PDB: 1282 件

3ZEE
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Electron cyro-microscopy helical reconstruction of Par-3 N terminal domain
分子名称: PARTITIONING DEFECTIVE 3 HOMOLOG
著者Zhang, Y, Wang, W, Chen, J, Zhang, K, Gao, F, Gong, W, Zhang, M, Sun, F, Feng, W.
登録日2012-12-05
公開日2013-10-16
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (6.1 Å)
主引用文献Structural Insights Into the Intrinsic Self-Assembly of Par-3 N-Terminal Domain.
Structure, 21, 2013
1THD
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BU of 1thd by Molmil
COMPLEX ORGANIZATION OF DENGUE VIRUS E PROTEIN AS REVEALED BY 9.5 ANGSTROM CRYO-EM RECONSTRUCTION
分子名称: Major envelope protein E
著者Zhang, Y, Zhang, W, Ogata, S, Clements, D, Strauss, J.H, Baker, T.S, Kuhn, R.J, Rossmann, M.G.
登録日2004-06-01
公開日2004-09-28
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (9.5 Å)
主引用文献Conformational changes of the flavivirus e glycoprotein
Structure, 12, 2004
4R7I
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BU of 4r7i by Molmil
Crystal structure of FMS kinase domain with a small molecular inhibitor, GLEEVEC
分子名称: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Macrophage colony-stimulating factor 1 receptor
著者Zhang, Y, Zhang, C.
登録日2014-08-27
公開日2015-08-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.
N Engl J Med, 373, 2015
1TGE
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BU of 1tge by Molmil
The structure of immature Dengue virus at 12.5 angstrom
分子名称: envelope glycoprotein
著者Zhang, Y, Zhang, W, Ogata, S, Clements, D, Strauss, J.H, Baker, T.S, Kuhn, R.J, Rossmann, M.G.
登録日2004-05-28
公開日2004-09-28
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (12.5 Å)
主引用文献Conformational changes of the flavivirus e glycoprotein.
Structure, 12, 2004
1TG8
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BU of 1tg8 by Molmil
The structure of Dengue virus E glycoprotein
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose, envelope glycoprotein
著者Zhang, Y, Zhang, W, Ogata, S, Clements, D, Strauss, J.H, Baker, T.S, Rossmann, M.G.
登録日2004-05-28
公開日2004-09-28
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Conformational changes of the flavivirus e glycoprotein
Structure, 12, 2004
5CRZ
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BU of 5crz by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand
分子名称: 1,2-ETHANEDIOL, 2-chloro-N-(1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)-4-fluorobenzenesulfonamide, Bromodomain-containing protein 4, ...
著者Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y.
登録日2015-07-23
公開日2016-01-13
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation
J.Med.Chem., 59, 2016
8JI9
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BU of 8ji9 by Molmil
Crystal Structure of cas7 and AcrIE10 complex
分子名称: Uncharacterized protein, type I-E Cascade subunit cas7
著者Zhang, Y, Yu, C.Z, Sun, S.Y.
登録日2023-05-26
公開日2024-07-24
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献A new anti-CRISPR gene promotes the spread of drug-resistance plasmids in Klebsiella pneumoniae.
Nucleic Acids Res., 2024
4RT7
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Crystal Structure of FLT3 with a small molecule inhibitor
分子名称: 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea, Receptor-type tyrosine-protein kinase FLT3
著者Zhang, Y, Zhang, C.
登録日2014-11-13
公開日2015-04-22
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397.
Cancer Discov, 5, 2015
8YM1
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BU of 8ym1 by Molmil
Structure of SADS-CoV Virus Nucleocapsid Protein
分子名称: nucleocapsid phosphoprotein
著者Zhang, Y, Wu, F, Xu, W.
登録日2024-03-08
公開日2024-07-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Unraveling the assembly mechanism of SADS-CoV virus nucleocapsid protein: insights from RNA binding, dimerization, and epitope diversity profiling
J.Virol., 2024
6J1L
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BU of 6j1l by Molmil
Crystal Structure Analysis of the ROR gamma(C455E)
分子名称: 2-[4-(ethylsulfonyl)phenyl]-N-[2'-fluoro-4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)[1,1'-biphenyl]-4-yl]acetamide, Nuclear receptor ROR-gamma
著者zhang, Y, Li, C.C, wu, X.S.
登録日2018-12-28
公開日2019-05-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer.
J.Med.Chem., 62, 2019
4XV2
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BU of 4xv2 by Molmil
B-Raf Kinase V600E oncogenic mutant in complex with Dabrafenib
分子名称: Dabrafenib, Serine/threonine-protein kinase B-raf
著者zhang, Y, zhang, c.
登録日2015-01-26
公開日2015-10-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
4XV3
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BU of 4xv3 by Molmil
B-Raf Kinase V600E oncogenic mutant in complex with PLX7922
分子名称: N'-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-N-ethyl-N-methylsulfuric diamide, Serine/threonine-protein kinase B-raf
著者Zhang, Y, Zhang, C.
登録日2015-01-26
公開日2015-10-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
4XV9
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B-Raf Kinase domain in complex with PLX5568
分子名称: N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamide, SULFATE ION, Serine/threonine-protein kinase B-raf
著者zhang, Y, zhang, c, wang, w.
登録日2015-01-26
公開日2015-10-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
4XV1
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BU of 4xv1 by Molmil
B-Raf Kinase V600E oncogenic mutant in complex with PLX7904
分子名称: N'-(3-{[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)-N-ethyl-N-methylsulfuric diamide, Serine/threonine-protein kinase B-raf
著者Zhang, Y, Zhang, C.
登録日2015-01-26
公開日2015-10-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
5VAI
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BU of 5vai by Molmil
Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein
分子名称: Glucagon-like peptide 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhang, Y, Sun, B, Feng, D, Hu, H, Chu, M, Qu, Q, Tarrasch, J.T, Li, S, Kobilka, T.S, Kobilka, B.K, Skiniotis, G.
登録日2017-03-27
公開日2017-05-24
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.
Nature, 546, 2017
5V22
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Crystal structure of human SETD2 SET-domain in complex with H3K36M peptide and SAH
分子名称: Histone H3K36M peptide, Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Zhang, Y, Tong, L.
登録日2017-03-02
公開日2017-03-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation.
Sci Rep, 7, 2017
4XVC
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Crystal structure of an esterase from the bacterial hormone-sensitive lipase (HSL) family
分子名称: Esterase E40, phenylmethanesulfonic acid
著者Zhang, Y, Li, P.
登録日2015-01-27
公開日2015-03-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Interdomain Hydrophobic Interactions Modulate the Thermostability of Microbial Esterases from the Hormone-Sensitive Lipase Family.
J.Biol.Chem., 290, 2015
4RZZ
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BU of 4rzz by Molmil
Crystal structure of metallopeptidase-like dimethylsulphoniopropionate (DMSP) lyase RlDddP in complex with phosphate
分子名称: FE (III) ION, GLYCEROL, PHOSPHATE ION, ...
著者Zhang, Y, Wang, P.
登録日2014-12-27
公開日2015-08-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold.
Mol.Microbiol., 98, 2015
4S00
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BU of 4s00 by Molmil
Crystal structure of metallopeptidase-like dimethylsulphoniopropionate (DMSP) lyase RlDddP mutant Y366A in complex with acrylate
分子名称: ACRYLIC ACID, FE (III) ION, GLYCEROL, ...
著者Zhang, Y, Wang, P.
登録日2014-12-27
公開日2015-08-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold.
Mol.Microbiol., 98, 2015
4RZY
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BU of 4rzy by Molmil
Crystal structure of metallopeptidase-like dimethylsulphoniopropionate (DMSP) lyase RlDddP in complex with MES
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FE (III) ION, Peptidase M24
著者Zhang, Y, Wang, P.
登録日2014-12-26
公開日2015-08-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.949 Å)
主引用文献Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold.
Mol.Microbiol., 98, 2015
4S01
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BU of 4s01 by Molmil
Crystal structure of metallopeptidase-like dimethylsulphoniopropionate (DMSP) lyase RlDddP mutant D377N in complex with acrylate
分子名称: ACRYLIC ACID, FE (III) ION, GLYCEROL, ...
著者Zhang, Y, Wang, P.
登録日2014-12-27
公開日2015-08-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold.
Mol.Microbiol., 98, 2015
5ADY
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Cryo-EM structures of the 50S ribosome subunit bound with HflX
分子名称: 23S RRNA, 50S RIBOSOMAL PROTEIN L1, 50S RIBOSOMAL PROTEIN L10, ...
著者Zhang, Y, Mandava, C.S, Cao, W, Li, X, Zhang, D, Li, N, Zhang, Y, Zhang, X, Qin, Y, Mi, K, Lei, J, Sanyal, S, Gao, N.
登録日2015-08-25
公開日2015-10-14
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Hflx is a Ribosome Splitting Factor Rescuing Stalled Ribosomes Under Stress Conditions
Nat.Struct.Mol.Biol., 22, 2015
1T8W
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Crystal Structure of E. coli AMP Nucleosidase
分子名称: AMP nucleosidase
著者Zhang, Y, Cottet, S.E, Ealick, S.E.
登録日2004-05-13
公開日2004-08-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of Escherichia coli AMP Nucleosidase Reveals Similarity to Nucleoside Phosphorylases
STRUCTURE, 12, 2004
1T8S
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Crystal Structure of E.coli AMP Nucleosidase complexed with formicin 5'-monophosphate
分子名称: AMP nucleosidase, FORMYCIN-5'-MONOPHOSPHATE
著者Zhang, Y, Cottet, S.E, Ealick, S.E.
登録日2004-05-13
公開日2004-08-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of Escherichia coli AMP Nucleosidase Reveals Similarity to Nucleoside Phosphorylases
STRUCTURE, 12, 2004
1T8Y
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Crystal Structure of E.coli AMP Nucleosidase complexed with phosphate
分子名称: AMP nucleosidase, PHOSPHATE ION
著者Zhang, Y, Cottet, S.E, Ealick, S.E.
登録日2004-05-13
公開日2004-08-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of Escherichia coli AMP Nucleosidase Reveals Similarity to Nucleoside Phosphorylases
STRUCTURE, 12, 2004

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