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PDB: 7 件
3CSF
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BU of 3csf by Molmil
Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor DW2
分子名称: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, RU-PYRIDOCARBAZOLE-2
著者Xie, P, Marmorstein, R.
登録日2008-04-09
公開日2008-05-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.
Acs Chem.Biol., 3, 2008
3CST
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BU of 3cst by Molmil
Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor E5E2
分子名称: Methylated Ruthenium Pyridocarbazole, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者Xie, P, Marmorstein, R.
登録日2008-04-10
公開日2008-05-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.
Acs Chem.Biol., 3, 2008
3Q4C
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BU of 3q4c by Molmil
Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292
分子名称: Serine/threonine-protein kinase B-raf, [(1,2,3,4,5,6-eta)-(1S,2R,3R,4R,5S,6S)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5H-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~N~1~,N~12~)ruthenium(1+)
著者Xie, P, Streu, C, Qin, J, Pregman, H, Pagano, N, Meggers, E, Marmorstein, R.
登録日2010-12-23
公開日2011-03-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase.
Biochemistry, 48, 2009
4E26
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BU of 4e26 by Molmil
BRAF in complex with an organic inhibitor 7898734
分子名称: 5-chloro-7-[(R)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol, Serine/threonine-protein kinase B-raf
著者Qin, J, Xie, P, Ventocilla, C, Zhou, G, Vultur, A, Chen, Q, Herlyn, M, Winkler, J, Marmorstein, R.
登録日2012-03-07
公開日2012-05-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Identification of a Novel Family of BRAF(V600E) Inhibitors.
J.Med.Chem., 55, 2012
1AGN
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BU of 1agn by Molmil
X-RAY STRUCTURE OF HUMAN SIGMA ALCOHOL DEHYDROGENASE
分子名称: ACETATE ION, HUMAN SIGMA ALCOHOL DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Hurley, T.D, Xie, P.
登録日1996-06-04
公開日1997-03-12
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity.
J.Biol.Chem., 272, 1997
1ZMS
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BU of 1zms by Molmil
LMP1 Protein binds to TRAF3 as a structural CD40
分子名称: Latent membrane protein 1, TNF receptor associated factor 3
著者Wu, S.D, Xie, P, Welsh, K, Li, C, Ni, C.-Z, Zhu, X, Reed, J.C, Satterthwait, A.C, Bishop, G.A, Ely, K.R.
登録日2005-05-10
公開日2005-07-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献LMP1 protein from the Epstein Barr virus is a structural CD40 decoy in B lymphocytes fro binding to TRAF3
J.Biol.Chem., 39, 2005
3KVQ
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BU of 3kvq by Molmil
Crystal structure of VEGFR2 extracellular domain D7
分子名称: Vascular endothelial growth factor receptor 2
著者Yang, Y, Opatowsky, Y, Xie, P, Schlessinger, J.
登録日2009-11-30
公開日2010-02-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling
Proc.Natl.Acad.Sci.USA, 107, 2010

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件を2024-10-09に公開中

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