4KGL
| Crystal structure of human alpha-L-iduronidase complex with [2R,3R,4R,5S]-2-carboxy-3,4,5-trihydroxy-piperidine | 分子名称: | (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Bie, H, Yin, J, He, X, Kermode, A.R, Goddard-Borger, E.D, Withers, S.G, James, M.N.G. | 登録日 | 2013-04-29 | 公開日 | 2013-09-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | 主引用文献 | Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase. Nat.Chem.Biol., 9, 2013
|
|
1CPU
| SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 5-HYDROXYMETHYL-CHONDURITOL, ... | 著者 | Brayer, G.D, Sidhu, G, Maurus, R, Rydberg, E.H, Braun, C, Wang, Y, Nguyen, N.T, Overall, C.M, Withers, S.G. | 登録日 | 1999-06-07 | 公開日 | 1999-06-14 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry, 39, 2000
|
|
6N1A
| Crystal structure of an N-acetylgalactosamine deacetylase from F. plautii | 分子名称: | CALCIUM ION, Carbohydrate-binding protein, GLYCEROL, ... | 著者 | Sim, L, Rahfeld, P, Withers, S.G. | 登録日 | 2018-11-08 | 公開日 | 2019-06-12 | 最終更新日 | 2020-01-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | An enzymatic pathway in the human gut microbiome that converts A to universal O type blood. Nat Microbiol, 4, 2019
|
|
6N1B
| Crystal structure of an N-acetylgalactosamine deacetylase from F. plautii in complex with blood group B trisaccharide | 分子名称: | CALCIUM ION, Carbohydrate-binding protein, GLYCEROL, ... | 著者 | Sim, L, Rahfeld, P, Withers, S.G. | 登録日 | 2018-11-08 | 公開日 | 2019-06-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | An enzymatic pathway in the human gut microbiome that converts A to universal O type blood. Nat Microbiol, 4, 2019
|
|
2YK5
| Structure of Neisseria LOS-specific sialyltransferase (NST), in complex with CMP. | 分子名称: | 1,2-ETHANEDIOL, CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE, CYTIDINE-5'-MONOPHOSPHATE, ... | 著者 | Lin, L.Y.C, Rakic, B, Chiu, C.P.C, Lameignere, E, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J. | 登録日 | 2011-05-25 | 公開日 | 2011-08-31 | 最終更新日 | 2019-09-25 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Structure and Mechanism of the Lipooligosaccharide Sialyltransferase from Neisseria Meningitidis J.Biol.Chem., 286, 2011
|
|
2IW0
| Structure of the chitin deacetylase from the fungal pathogen Colletotrichum lindemuthianum | 分子名称: | ACETATE ION, CHITIN DEACETYLASE, CHLORIDE ION, ... | 著者 | Blair, D.E, Hekmat, O, Schuttelkopf, A.W, Shrestha, B, Tokuyasu, K, Withers, S.G, van Aalten, D.M.F. | 登録日 | 2006-06-23 | 公開日 | 2006-07-04 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structure and Mechanism of Chitin Deacetylase from the Fungal Pathogen Colletotrichum Lindemuthianum. Biochemistry, 45, 2006
|
|
1EXP
| BETA-1,4-GLYCANASE CEX-CD | 分子名称: | BETA-1,4-D-GLYCANASE CEX-CD, beta-D-glucopyranose-(1-4)-2-deoxy-2-fluoro-alpha-D-glucopyranose | 著者 | White, A, Tull, D, Johns, K.L, Withers, S.G, Rose, D.R. | 登録日 | 1996-01-11 | 公開日 | 1997-01-27 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystallographic observation of a covalent catalytic intermediate in a beta-glycosidase. Nat.Struct.Biol., 3, 1996
|
|
2YK6
| Structure of Neisseria LOS-specific sialyltransferase (NST), in complex with CDP. | 分子名称: | CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE, CYTIDINE-5'-DIPHOSPHATE, PENTAETHYLENE GLYCOL, ... | 著者 | Lin, L.Y.C, Rakic, B, Chiu, C.P.C, Lameignere, E, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J. | 登録日 | 2011-05-25 | 公開日 | 2011-08-31 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Structure and Mechanism of the Lipooligosaccharide Sialyltransferase from Neisseria Meningitidis J.Biol.Chem., 286, 2011
|
|
2GK1
| X-ray crystal structure of NGT-bound HexA | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, Beta-hexosaminidase subunit alpha, ... | 著者 | Lemieux, M.J, Mark, B.L, Cherney, M.M, Withers, S.G, Mahuran, D.J, James, M.N. | 登録日 | 2006-03-31 | 公開日 | 2006-05-30 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Crystallographic Structure of Human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of G(M2) Ganglioside Hydrolysis. J.Mol.Biol., 359, 2006
|
|
2JCK
| Crystal structure of alpha-1,3 Galactosyltransferase (R365K) in complex with UDP and 2 manganese ion | 分子名称: | MANGANESE (II) ION, N-ACETYLLACTOSAMINIDE ALPHA-1,3-GALACTOSYLTRANSFERASE, URIDINE-5'-DIPHOSPHATE | 著者 | Jamaluddin, H, Tumbale, P, Withers, S.G, Acharya, K.R, Brew, K. | 登録日 | 2006-12-26 | 公開日 | 2007-05-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Conformational Changes Induced by Binding Udp-2F-Galactose to Alpha-1,3 Galactosyltransferase-Implications for Catalysis. J.Mol.Biol., 369, 2007
|
|
2JCL
| Crystal structure of alpha-1,3 Galactosyltransferase (R365K) in the absence of ligands | 分子名称: | N-ACETYLLACTOSAMINIDE ALPHA-1,3-GALACTOSYLTRANSFERASE, SULFATE ION | 著者 | Jamaluddin, H, Tumbale, P, Withers, S.G, Acharya, K.R, Brew, K. | 登録日 | 2006-12-26 | 公開日 | 2007-05-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | 主引用文献 | Conformational Changes Induced by Binding Udp-2F-Galactose to Alpha-1,3 Galactosyltransferase-Implications for Catalysis. J.Mol.Biol., 369, 2007
|
|
2JCJ
| Crystal structure of alpha-1,3 Galactosyltransferase (C-terminus truncated mutant-C3) in complex with UDP and Tris | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... | 著者 | Jamaluddin, H, Tumbale, P, Withers, S.G, Acharya, K.R, Brew, K. | 登録日 | 2006-12-25 | 公開日 | 2007-05-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Conformational Changes Induced by Binding Udp-2F-Galactose to Alpha-1,3 Galactosyltransferase-Implications for Catalysis. J.Mol.Biol., 369, 2007
|
|
2JCO
| Crystal structure of wild type alpha-1,3 Galactosyltransferase in the absence of ligands | 分子名称: | GLYCEROL, N-ACETYLLACTOSAMINIDE ALPHA-1,3-GALACTOSYL TRANSFERASE | 著者 | Jamaluddin, H, Tumbale, P, Withers, S.G, Acharya, K.R, Brew, K. | 登録日 | 2006-12-28 | 公開日 | 2007-06-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Conformational Changes Induced by Binding Udp-2F-Galactose to Alpha-1,3 Galactosyltransferase-Implications for Catalysis. J.Mol.Biol., 369, 2007
|
|
2YK7
| Structure of Neisseria LOS-specific sialyltransferase (NST), in complex with CMP-3F-Neu5Ac. | 分子名称: | 1,2-ETHANEDIOL, CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE, CYTIDINE-5'-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC ACID, ... | 著者 | Lin, L.Y.C, Rakic, B, Chiu, C.P.C, Lameignere, E, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J. | 登録日 | 2011-05-25 | 公開日 | 2011-08-31 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Structure and Mechanism of the Lipooligosaccharide Sialyltransferase from Neisseria Meningitidis J.Biol.Chem., 286, 2011
|
|
2YK4
| Structure of Neisseria LOS-specific sialyltransferase (NST). | 分子名称: | 1,2-ETHANEDIOL, 2-(2-{2-[2-(2-{2-[2-(2-{2-[4-(1,1,3,3-TETRAMETHYL-BUTYL)-PHENOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOX Y}-ETHOXY)-ETHANOL, CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE, ... | 著者 | Lin, L.Y.C, Rakic, B, Chiu, C.P.C, Lameignere, E, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J. | 登録日 | 2011-05-25 | 公開日 | 2011-08-31 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structure and Mechanism of the Lipooligosaccharide Sialyltransferase from Neisseria Meningitidis J.Biol.Chem., 286, 2011
|
|
2GJX
| Crystallographic structure of human beta-Hexosaminidase A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-hexosaminidase alpha chain, ... | 著者 | Lemieux, M.J, Mark, B.L, Cherney, M.M, Withers, S.G, Mahuran, D.J, James, M.N.G. | 登録日 | 2006-03-31 | 公開日 | 2006-06-20 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystallographic structure of human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss
of GM2 Ganglioside Hydrolysis J.Mol.Biol., 359, 2006
|
|
1QX1
| Golgi alpha-mannosidase II D341N mutant complex with 2-F-mannosyl-F | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-2-fluoro-beta-D-mannopyranosyl fluoride, ... | 著者 | Numao, S, Kuntz, D.A, Withers, S.G, Rose, D.R. | 登録日 | 2003-09-04 | 公開日 | 2003-10-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates. J.Biol.Chem., 278, 2003
|
|
1XCX
| Acarbose Rearrangement Mechanism Implied by the Kinetic and Structural Analysis of Human Pancreatic alpha-Amylase in Complex with Analogues and Their Elongated Counterparts | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-6)-beta-D-glucopyranose, Alpha-amylase, ... | 著者 | Li, C, Begum, A, Numao, S, Park, K.H, Withers, S.G, Brayer, G.D. | 登録日 | 2004-09-03 | 公開日 | 2004-12-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Acarbose Rearrangement Mechanism Implied by the Kinetic and Structural Analysis of Human Pancreatic alpha-Amylase in Complex with Analogues and Their Elongated Counterparts Biochemistry, 44, 2005
|
|
4NCS
| Human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate) | 分子名称: | (2S,3S,4R,5R,6R)-5-acetamido-2,3-bis(fluoranyl)-4-oxidanyl-6-[(1S,2S)-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid, PHOSPHATE ION, Sialidase-2 | 著者 | Buchini, S, Gallat, F.-X, Greig, I.R, Kim, J.-H, Wakatsuki, S, Chavas, L.M.G, Withers, S.G. | 登録日 | 2013-10-25 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.201 Å) | 主引用文献 | Tuning mechanism-based inactivators of neuraminidases: mechanistic and structural insights. Angew.Chem.Int.Ed.Engl., 53, 2014
|
|
1XCW
| Acarbose Rearrangement Mechanism Implied by the Kinetic and Structural Analysis of Human Pancreatic alpha-Amylase in Complex with Analogues and Their Elongated Counterparts | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, Alpha-amylase, ... | 著者 | Li, C, Begum, A, Numao, S, Park, K.H, Withers, S.G, Brayer, G.D. | 登録日 | 2004-09-03 | 公開日 | 2004-12-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Acarbose Rearrangement Mechanism Implied by the Kinetic and Structural Analysis of Human Pancreatic alpha-Amylase in Complex with Analogues and Their Elongated Counterparts Biochemistry, 44, 2005
|
|
1XD0
| Acarbose Rearrangement Mechanism Implied by the Kinetic and Structural Analysis of Human Pancreatic alpha-Amylase in Complex with Analogues and Their Elongated Counterparts | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACARBOSE DERIVED PENTASACCHARIDE, Alpha-amylase, ... | 著者 | Li, C, Begum, A, Numao, S, Park, K.H, Withers, S.G, Brayer, G.D. | 登録日 | 2004-09-03 | 公開日 | 2004-12-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Acarbose Rearrangement Mechanism Implied by the Kinetic and Structural Analysis of Human Pancreatic alpha-Amylase in Complex with Analogues and Their Elongated Counterparts Biochemistry, 44, 2005
|
|
4MJ2
| Crystal structure of apo-iduronidase in the R3 form | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-L-iduronidase, ... | 著者 | Bie, H, Yin, J, He, X, Kermode, A.R, Goddard-Borger, E.D, Withers, S.G, James, M.N.G. | 登録日 | 2013-09-03 | 公開日 | 2013-09-18 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase. Nat.Chem.Biol., 9, 2013
|
|
1XH1
| Structure of the N298S variant of human pancreatic alpha-amylase complexed with chloride | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-amylase, pancreatic, ... | 著者 | Maurus, R, Begum, A, Kuo, H.H, Racaza, A, Numao, S, Overall, C.M, Withers, S.G, Brayer, G.D. | 登録日 | 2004-09-17 | 公開日 | 2005-05-24 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structural and mechanistic studies of chloride induced activation of human pancreatic alpha-amylase PROTEIN SCI., 14, 2005
|
|
1XH2
| Structure of the N298S variant of human pancreatic alpha-amylase complexed with chloride and acarbose | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACARBOSE DERIVED PENTASACCHARIDE, Alpha-amylase, ... | 著者 | Maurus, R, Begum, A, Kuo, H.H, Racaza, A, Numao, S, Overall, C.M, Withers, S.G, Brayer, G.D. | 登録日 | 2004-09-17 | 公開日 | 2005-05-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and mechanistic studies of chloride induced activation of human pancreatic alpha-amylase PROTEIN SCI., 14, 2005
|
|
1XSI
| Structure of a Family 31 alpha glycosidase | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ACETIC ACID, Putative family 31 glucosidase yicI, ... | 著者 | Lovering, A.L, Lee, S.S, Kim, Y.W, Withers, S.G, Strynadka, N.C. | 登録日 | 2004-10-19 | 公開日 | 2004-10-26 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Mechanistic and Structural Analysis of a Family 31 alpha-Glycosidase and Its Glycosyl-enzyme Intermediate J.Biol.Chem., 280, 2005
|
|