8T6H
 
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2BSK
 | | Crystal structure of the TIM9 Tim10 hexameric complex | | 分子名称: | MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10, MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9 A | | 著者 | Webb, C.T, Gorman, M.A, Lazarus, M, Ryan, M.T, Gulbis, J.M. | | 登録日 | 2005-05-23 | | 公開日 | 2006-01-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Crystal Structure of the Mitochondrial Chaperone Tim910 Reveals a Six-Bladed Alpha-Propeller.
Mol.Cell, 21, 2006
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3DXR
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7RIE
 | | Plasmodium falciparum M17 in complex with inhibitor MIPS2571 | | 分子名称: | CARBONATE ION, M17 leucyl aminopeptidase, N-{(1R)-2-(hydroxyamino)-1-[4'-(hydroxymethyl)[1,1'-biphenyl]-4-yl]-2-oxoethyl}-2,2-dimethylpropanamide, ... | | 著者 | Webb, C.T, McGowan, S. | | 登録日 | 2021-07-19 | | 公開日 | 2022-09-14 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Genetic and chemical validation of Plasmodium falciparum aminopeptidase Pf A-M17 as a drug target in the hemoglobin digestion pathway.
Elife, 11, 2022
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7T3V
 | | Metal dependent activation of Plasmodium falciparum M17 aminopeptidase, spacegroup P22121 after crystals soaked with Zn2+ | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CARBONATE ION, M17 leucyl aminopeptidase, ... | | 著者 | Webb, C.T, McGowan, S. | | 登録日 | 2021-12-08 | | 公開日 | 2022-06-29 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase.
J.Biol.Chem., 298, 2022
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7SRV
 | | Metal dependent activation of Plasmodium falciparum M17 aminopeptidase (inactive form), spacegroup P22121 | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | | 著者 | Webb, C.T, McGowan, S. | | 登録日 | 2021-11-08 | | 公開日 | 2022-06-29 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase.
J.Biol.Chem., 298, 2022
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8T83
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8T7P
 | | X-ray crystal structure of PfA-M1(M462S) | | 分子名称: | Aminopeptidase N, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Yang, W, Drinkwater, N, Webb, C.T, McGowan, S. | | 登録日 | 2023-06-21 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Conformational dynamics of the Plasmodium falciparum M1 aminopeptidase.
To Be Published
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8EX3
 | | Plasmodium falciparum M1 in complex with inhibitor 9aa | | 分子名称: | GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ... | | 著者 | Calic, P.P.S, McGowan, S, Webb, C.T. | | 登録日 | 2022-10-24 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Eur.J.Med.Chem., 248, 2022
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8EYE
 | | Plasmodium falciparum M1 in complex with inhibitor 9aj | | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... | | 著者 | Calic, P.P.S, McGowan, S, Webb, C.T. | | 登録日 | 2022-10-26 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Eur.J.Med.Chem., 248, 2022
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8EYD
 | | Plasmodium falciparum M1 in complex with inhibitor 15ah | | 分子名称: | GLYCEROL, M1 family aminopeptidase, N-[(1R)-1-(4-bromophenyl)-2-(hydroxyamino)-2-oxoethyl]-N~2~-(4-fluorophenyl)glycinamide, ... | | 著者 | Calic, P.P.S, McGowan, S, Webb, C.T. | | 登録日 | 2022-10-26 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Eur.J.Med.Chem., 248, 2022
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8EWZ
 | | Plasmodium falciparum M1 in complex with inhibitor 9c | | 分子名称: | (2R)-2-(cyclopentylcarbamamido)-N-hydroxy-2-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)acetamide, DIMETHYL SULFOXIDE, GLYCEROL, ... | | 著者 | Calic, P.P.S, McGowan, S, Webb, C.T. | | 登録日 | 2022-10-24 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Eur.J.Med.Chem., 248, 2022
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8EYF
 | | Plasmodium falciparum M1 in complex with inhibitor 15aa | | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... | | 著者 | Calic, P.P.S, McGowan, S, Webb, C.T. | | 登録日 | 2022-10-26 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Eur.J.Med.Chem., 248, 2022
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8EZ4
 | | Plasmodium falciparum M17 in complex with inhibitor 9aa | | 分子名称: | CARBONATE ION, M17 leucyl aminopeptidase, N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-N~2~-phenylglycinamide, ... | | 著者 | Calic, P.P.S, McGowan, S, Webb, C.T. | | 登録日 | 2022-10-31 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Eur.J.Med.Chem., 248, 2022
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8EZ2
 | | Plasmodium falciparum M1 in complex with inhibitor 15ag | | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... | | 著者 | Calic, P.P.S, McGowan, S, Webb, C.T. | | 登録日 | 2022-10-31 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Eur.J.Med.Chem., 248, 2022
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