7VFW
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![BU of 7vfw by Molmil](/molmil-images/mine/7vfw) | Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to CaV2.2-blocker1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazole, CALCIUM ION, ... | 著者 | Dong, Y, Gao, Y, Wang, Y, Zhao, Y. | 登録日 | 2021-09-13 | 公開日 | 2021-11-03 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2. Cell Rep, 37, 2021
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7VFS
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![BU of 7vfs by Molmil](/molmil-images/mine/7vfs) | Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, apo state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Dong, Y, Gao, Y, Wang, Y, Zhao, Y. | 登録日 | 2021-09-13 | 公開日 | 2021-11-03 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2. Cell Rep, 37, 2021
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5XAF
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![BU of 5xaf by Molmil](/molmil-images/mine/5xaf) | Crystal structure of tubulin-stathmin-TTL-Compound Z1 complex | 分子名称: | (3S,4R)-4-(3-hydroxy-4-methoxyphenyl)-3-methyl-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Zhang, H, Luo, C, Wang, Y. | 登録日 | 2017-03-12 | 公開日 | 2017-12-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.551 Å) | 主引用文献 | Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents Eur J Med Chem, 144, 2017
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8K3G
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1LQX
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![BU of 1lqx by Molmil](/molmil-images/mine/1lqx) | Crystal structure of V45E mutant of cytochrome b5 | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, cytochrome b5 | 著者 | Gan, J.-H, Wu, J, Wang, Z.-Q, Wang, Y.-H, Huang, Z.-X, Xia, Z.-X. | 登録日 | 2002-05-14 | 公開日 | 2002-09-04 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structures of V45E and V45Y mutants and structure comparison of a variety of cytochrome b5 mutants. Acta Crystallogr.,Sect.D, 58, 2002
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5XAG
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![BU of 5xag by Molmil](/molmil-images/mine/5xag) | Crystal structure of tubulin-stathmin-TTL-Compound Z2 complex | 分子名称: | (3~{R},4~{R})-3-(hydroxymethyl)-4-(4-methoxy-3-oxidanyl-phenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Zhang, H, Luo, C, Wang, Y. | 登録日 | 2017-03-12 | 公開日 | 2018-01-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents Eur J Med Chem, 144, 2017
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1AHC
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1AHA
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![BU of 1aha by Molmil](/molmil-images/mine/1aha) | THE N-GLYCOSIDASE MECHANISM OF RIBOSOME-INACTIVATING PROTEINS IMPLIED BY CRYSTAL STRUCTURES OF ALPHA-MOMORCHARIN | 分子名称: | ADENINE, ALPHA-MOMORCHARIN | 著者 | Ren, J, Wang, Y, Dong, Y, Stuart, D.I. | 登録日 | 1994-01-07 | 公開日 | 1994-06-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The N-glycosidase mechanism of ribosome-inactivating proteins implied by crystal structures of alpha-momorcharin. Structure, 2, 1994
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1AHB
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![BU of 1ahb by Molmil](/molmil-images/mine/1ahb) | THE N-GLYCOSIDASE MECHANISM OF RIBOSOME-INACTIVATING PROTEINS IMPLIED BY CRYSTAL STRUCTURES OF ALPHA-MOMORCHARIN | 分子名称: | ALPHA-MOMORCHARIN, FORMYCIN-5'-MONOPHOSPHATE | 著者 | Ren, J, Wang, Y, Dong, Y, Stuart, D.I. | 登録日 | 1994-01-07 | 公開日 | 1994-06-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The N-glycosidase mechanism of ribosome-inactivating proteins implied by crystal structures of alpha-momorcharin. Structure, 2, 1994
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7VIB
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![BU of 7vib by Molmil](/molmil-images/mine/7vib) | Crystal structure of human ACE2 and GX/P2V RBD | 分子名称: | Angiotensin-converting enzyme 2, Spike glycoprotein, ZINC ION | 著者 | Guo, Y, Cao, W, Jia, N, Wang, W, Yuan, S, Wang, Y. | 登録日 | 2021-09-26 | 公開日 | 2022-10-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structure of human ACE2 and GX/P2V RBD To Be Published
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1ES1
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![BU of 1es1 by Molmil](/molmil-images/mine/1es1) | CRYSTAL STRUCTURE OF VAL61HIS MUTANT OF TRYPSIN-SOLUBILIZED FRAGMENT OF CYTOCHROME B5 | 分子名称: | CYTOCHROME B5, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Wu, J, Gan, J.-H, Xia, Z.-X, Wang, Y.-H, Wang, W.-H, Xue, L.-L, Xie, Y, Huang, Z.-X. | 登録日 | 2000-04-07 | 公開日 | 2000-08-09 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of recombinant trypsin-solubilized fragment of cytochrome b(5) and the structural comparison with Val61His mutant. Proteins, 40, 2000
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1EHB
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![BU of 1ehb by Molmil](/molmil-images/mine/1ehb) | CRYSTAL STRUCTURE OF RECOMBINANT TRYPSIN-SOLUBILIZED FRAGMENT OF CYTOCHROME B5 | 分子名称: | PROTEIN (CYTOCHROME B5), PROTOPORPHYRIN IX CONTAINING FE | 著者 | Wu, J, Gan, J.-H, Xia, Z.-X, Wang, Y.-H, Wang, W.-H, Xue, L.-L, Xie, Y, Huang, Z.-X. | 登録日 | 2000-02-20 | 公開日 | 2000-08-09 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of recombinant trypsin-solubilized fragment of cytochrome b(5) and the structural comparison with Val61His mutant. Proteins, 40, 2000
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8YM2
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![BU of 8ym2 by Molmil](/molmil-images/mine/8ym2) | Crystal structure of AIDA-1 PTB domain in complex with SynGAP NPxF motif | 分子名称: | Ankyrin repeat and sterile alpha motif domain-containing protein 1B, Ras/Rap GTPase-activating protein SynGAP | 著者 | Wang, X, Wang, Y, Cai, Q, Zhang, M. | 登録日 | 2024-03-08 | 公開日 | 2024-05-29 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity and Specificity. J.Mol.Biol., 436, 2024
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8IL5
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8IKU
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8YU9
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![BU of 8yu9 by Molmil](/molmil-images/mine/8yu9) | Tubulin-RB3-TTL in complex with compound SI10 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-chloranylthieno[3,2-d]pyrimidin-4-yl)-7-methoxy-1,3-dihydroquinoxalin-2-one, CALCIUM ION, ... | 著者 | Wu, C.Y, Wang, Y.X. | 登録日 | 2024-03-27 | 公開日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | The crystal structure of tubulin-RB3-TTL in complex with compound AB10 To Be Published
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8YTX
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![BU of 8ytx by Molmil](/molmil-images/mine/8ytx) | Tubulin-RB3-TTL in complex with compound SI9 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloranyl-~{N}-(4-methoxyphenyl)-~{N}-methyl-thieno[2,3-d]pyrimidin-4-amine, CALCIUM ION, ... | 著者 | Wu, C.Y, Wang, Y.X. | 登録日 | 2024-03-26 | 公開日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Tubulin-RB3-TTL in complex with compound SI9 To Be Published
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8YUA
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![BU of 8yua by Molmil](/molmil-images/mine/8yua) | Tubulin-RB3-TTL in complex with compound SI10 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloranyl-~{N}-(4-methoxyphenyl)-~{N}-methyl-thieno[3,2-d]pyrimidin-4-amine, CALCIUM ION, ... | 著者 | Wu, C.Y, Wang, Y.X. | 登録日 | 2024-03-27 | 公開日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | The complex structure of tubulin-RB3-TTL in complex with compound SI10 To Be Published
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5VEX
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![BU of 5vex by Molmil](/molmil-images/mine/5vex) | Structure of the human GLP-1 receptor complex with NNC0640 | 分子名称: | 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide, Glucagon-like peptide 1 receptor, Endolysin chimera | 著者 | Song, G, Yang, D, Wang, Y, Graaf, C.D, Zhou, Q, Jiang, S, Liu, K, Cai, X, Dai, A, Lin, G, Liu, D, Wu, F, Wu, Y, Zhao, S, Ye, L, Han, G.W, Lau, J, Wu, B, Hanson, M.A, Liu, Z.-J, Wang, M.-W, Stevens, R.C. | 登録日 | 2017-04-05 | 公開日 | 2017-05-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature, 546, 2017
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4AUA
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![BU of 4aua by Molmil](/molmil-images/mine/4aua) | Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6) | 分子名称: | 1H-benzimidazol-2-yl(1H-pyrrol-2-yl)methanone, CYCLIN-DEPENDENT KINASE 6 | 著者 | Cho, Y.S, Angove, H, Brain, C, Chen, C.H.T, Cheng, R, Chopra, R, Chung, K, Congreve, M, Dagostin, C, Davis, D, Feltell, R, Giraldes, J, Hiscock, S, Kim, S, Kovats, S, Lagu, B, Lewry, K, Loo, A, Lu, Y, Luzzio, M, Maniara, W, Mcmenamin, R, Mortenson, P, Benning, R, O'Reilly, M, Rees, D, Shen, J, Smith, T, Wang, Y, Williams, G, Woolford, A, Wrona, W, Xu, M, Yang, F, Howard, S. | 登録日 | 2012-05-15 | 公開日 | 2013-02-06 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors. ACS Med Chem Lett, 3, 2012
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6QGK
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![BU of 6qgk by Molmil](/molmil-images/mine/6qgk) | Structure of human Bcl-2 in complex with THIQ-phenyl pyrazole compound | 分子名称: | 1-[2-[[(3~{S})-3-(aminomethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]phenyl]-~{N},~{N}-dibutyl-5-methyl-pyrazole-3-carboxamide, ACETATE ION, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1 | 著者 | Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. | 登録日 | 2019-01-11 | 公開日 | 2019-06-12 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1. Acs Omega, 4, 2019
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8JFU
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![BU of 8jfu by Molmil](/molmil-images/mine/8jfu) | AcrIIA15 in complex with palindromic DNA substrate | 分子名称: | AcrIIA15, DNA (5'-D(*AP*TP*TP*AP*TP*GP*AP*CP*AP*AP*AP*TP*GP*TP*CP*AP*TP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*AP*TP*GP*AP*CP*AP*TP*TP*TP*GP*TP*CP*AP*TP*AP*A)-3') | 著者 | Deng, X, Wang, Y. | 登録日 | 2023-05-18 | 公開日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | AcrIIA15 in complex with palindromic DNA substrate To Be Published
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8GXD
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![BU of 8gxd by Molmil](/molmil-images/mine/8gxd) | L-LEUCINE DEHYDROGENASE FROM EXIGUOBACTERIUM SIBIRICUM | 分子名称: | CALCIUM ION, GLYCEROL, Glu/Leu/Phe/Val dehydrogenase | 著者 | Mu, X, Nie, Y, Wu, T, Wang, Y, Zhang, N, Yin, D, Xu, Y. | 登録日 | 2022-09-19 | 公開日 | 2023-04-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | 主引用文献 | Reshaping Substrate-Binding Pocket of Leucine Dehydrogenase for Bidirectionally Accessing Structurally Diverse Substrates Acs Catalysis, 13, 2023
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6QFI
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![BU of 6qfi by Molmil](/molmil-images/mine/6qfi) | Structure of human Mcl-1 in complex with BIM BH3 peptide | 分子名称: | Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION | 著者 | Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. | 登録日 | 2019-01-10 | 公開日 | 2019-06-12 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1. Acs Omega, 4, 2019
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6QFQ
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![BU of 6qfq by Molmil](/molmil-images/mine/6qfq) | Structure of human Mcl-1 in complex with indole acid inhibitor | 分子名称: | 7-(3,5-dimethyl-1~{H}-pyrazol-4-yl)-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. | 登録日 | 2019-01-10 | 公開日 | 2019-06-12 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1. Acs Omega, 4, 2019
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