2H40
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h40 by Molmil](/molmil-images/mine/2h40) | Crystal structure of the catalytic domain of unliganded PDE5 | 分子名称: | MAGNESIUM ION, ZINC ION, cGMP-specific 3',5'-cyclic phosphodiesterase | 著者 | Wang, H, Liu, Y, Huai, Q, Cai, J, Zoraghi, R, Francis, S.H, Corbin, J.D, Robinson, H, Xin, Z, Lin, G, Ke, H. | 登録日 | 2006-05-23 | 公開日 | 2006-06-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development J.Biol.Chem., 281, 2006
|
|
5J0F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5j0f by Molmil](/molmil-images/mine/5j0f) | Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P4/5 | 分子名称: | GLYCEROL, Superoxide dismutase [Cu-Zn],OXIDOREDUCTASE,Superoxide dismutase [Cu-Zn] | 著者 | Wang, H, Lang, L, Logan, D, Danielsson, J, Oliveberg, M. | 登録日 | 2016-03-28 | 公開日 | 2017-02-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Tricking a Protein To Swap Strands. J. Am. Chem. Soc., 138, 2016
|
|
2QYK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2qyk by Molmil](/molmil-images/mine/2qyk) | Crystal structure of PDE4A10 in complex with inhibitor NPV | 分子名称: | 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, Cyclic AMP-specific phosphodiesterase HSPDE4A10, MAGNESIUM ION, ... | 著者 | Wang, H, Peng, M, Chen, Y, Geng, J, Robinson, H, Houslay, M. | 登録日 | 2007-08-15 | 公開日 | 2008-04-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem.J., 408, 2007
|
|
2H42
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h42 by Molmil](/molmil-images/mine/2h42) | Crystal structure of PDE5 in complex with sildenafil | 分子名称: | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, MAGNESIUM ION, ZINC ION, ... | 著者 | Wang, H, Ke, H. | 登録日 | 2006-05-23 | 公開日 | 2006-06-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development J.Biol.Chem., 281, 2006
|
|
2H44
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2h44 by Molmil](/molmil-images/mine/2h44) | Crystal structure of PDE5A1 in complex with icarisid II | 分子名称: | 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-8-(3-METHYLBUTYL)-4-OXO-4H-CHROMEN-3-YL 6-DEOXY-ALPHA-L-MANNOPYRANOSIDE, MAGNESIUM ION, ZINC ION, ... | 著者 | Wang, H, Ke, H. | 登録日 | 2006-05-23 | 公開日 | 2006-06-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development J.Biol.Chem., 281, 2006
|
|
3ECN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ecn by Molmil](/molmil-images/mine/3ecn) | Crystal structure of PDE8A catalytic domain in complex with IBMX | 分子名称: | 3-ISOBUTYL-1-METHYLXANTHINE, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | 著者 | Wang, H, Yan, Z, Yang, S, Cai, J, Robinson, H, Ke, H. | 登録日 | 2008-09-01 | 公開日 | 2008-11-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity Biochemistry, 47, 2008
|
|
2F5H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f5h by Molmil](/molmil-images/mine/2f5h) | Solution structure of the alpha-domain of human Metallothionein-3 | 分子名称: | CADMIUM ION, Metallothionein-3 | 著者 | Wang, H, Zhang, Q, Cai, B, Li, H.Y, Sze, K.H, Huang, Z.X, Wu, H.M, Sun, H.Z. | 登録日 | 2005-11-25 | 公開日 | 2006-05-30 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and dynamics of human metallothionein-3 (MT-3) Febs Lett., 580, 2006
|
|
4MMC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4mmc by Molmil](/molmil-images/mine/4mmc) | |
2CW4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2cw4 by Molmil](/molmil-images/mine/2cw4) | Crystal structure of TTHA0137 from Thermus Thermophilus HB8 | 分子名称: | translation initiation inhibitor | 著者 | Wang, H, Murayama, K, Terada, T, Shirouzu, M, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2005-06-16 | 公開日 | 2005-12-16 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of TTHA0137 from Thermus Thermophilus HB8 TO BE PUBLISHED
|
|
3X0T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3x0t by Molmil](/molmil-images/mine/3x0t) | Crystal structure of PirA | 分子名称: | NITRATE ION, Uncharacterized protein | 著者 | Wang, H.C, Ko, T.P, Wang, A.H.J, Lo, C.F. | 登録日 | 2014-10-22 | 公開日 | 2015-08-26 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | 主引用文献 | The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
3X0U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3x0u by Molmil](/molmil-images/mine/3x0u) | Crystal structure of PirB | 分子名称: | Uncharacterized protein | 著者 | Wang, H.C, Ko, T.P, Wang, A.H.J, Lo, C.F. | 登録日 | 2014-10-22 | 公開日 | 2015-08-26 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
4XCR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4xcr by Molmil](/molmil-images/mine/4xcr) | Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant I35A | 分子名称: | Superoxide dismutase [Cu-Zn] | 著者 | Wang, H, Logan, D.T, Danielsson, J, Mu, X, Binolfi, A, Theillet, F, Bekei, B, Lang, L, Wennerstrom, H, Selenko, P, Oliveberg, M. | 登録日 | 2014-12-18 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.602 Å) | 主引用文献 | Thermodynamics of protein destabilization in live cells. Proc. Natl. Acad. Sci. U.S.A., 112, 2015
|
|
2YW8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2yw8 by Molmil](/molmil-images/mine/2yw8) | Crystal structure of human RUN and FYVE domain-containing protein | 分子名称: | RUN and FYVE domain-containing protein 1, SULFATE ION, ZINC ION | 著者 | Wang, H, Kishishita, S, Murayama, K, Takemoto, C, Terada, T, Shirouzu, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2007-04-20 | 公開日 | 2008-04-22 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of human RUN and FYVE domain-containing protein To be Published
|
|
6KA0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ka0 by Molmil](/molmil-images/mine/6ka0) | |
2YV6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2yv6 by Molmil](/molmil-images/mine/2yv6) | Crystal structure of human Bcl-2 family protein Bak | 分子名称: | Bcl-2 homologous antagonist/killer, SULFATE ION | 著者 | Wang, H, Kishishita, S, Murayama, K, Takemoto, C, Terada, T, Shirouzu, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2007-04-09 | 公開日 | 2008-04-15 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator. J.Struct.Biol., 166, 2009
|
|
6KA1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ka1 by Molmil](/molmil-images/mine/6ka1) | |
5YQM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5yqm by Molmil](/molmil-images/mine/5yqm) | Crystal structure of Sirt2 in complex with selective inhibitor A29 | 分子名称: | 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-(4-phenylsulfanylphenyl)ethanamide, BETA-MERCAPTOETHANOL, NAD-dependent protein deacetylase sirtuin-2, ... | 著者 | Wang, H, Yu, Y, Li, G, chen, Q. | 登録日 | 2017-11-07 | 公開日 | 2018-10-17 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.735 Å) | 主引用文献 | X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem, 155, 2018
|
|
3LFV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3lfv by Molmil](/molmil-images/mine/3lfv) | crystal structure of unliganded PDE5A GAF domain | 分子名称: | cGMP-specific 3',5'-cyclic phosphodiesterase | 著者 | Wang, H, Robinson, H, Ke, H. | 登録日 | 2010-01-18 | 公開日 | 2010-09-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain. J.Biol.Chem., 285, 2010
|
|
2R8Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2r8q by Molmil](/molmil-images/mine/2r8q) | Structure of LmjPDEB1 in complex with IBMX | 分子名称: | 3-ISOBUTYL-1-METHYLXANTHINE, Class I phosphodiesterase PDEB1, MAGNESIUM ION, ... | 著者 | Wang, H, Yan, Z, Geng, J, Kunz, S, Seebeck, T, Ke, H. | 登録日 | 2007-09-11 | 公開日 | 2007-12-18 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors. Mol.Microbiol., 66, 2007
|
|
5WH5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5wh5 by Molmil](/molmil-images/mine/5wh5) | |
3VJZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3vjz by Molmil](/molmil-images/mine/3vjz) | |
5Z3W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5z3w by Molmil](/molmil-images/mine/5z3w) | Malate dehydrogenase binds silver at C113 | 分子名称: | Malate dehydrogenase, SILVER ION | 著者 | Wang, H, Wang, M, Sun, H. | 登録日 | 2018-01-09 | 公開日 | 2019-01-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm Chem Sci, 2020
|
|
3MF0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mf0 by Molmil](/molmil-images/mine/3mf0) | Crystal structure of PDE5A GAF domain (89-518) | 分子名称: | cGMP-specific 3',5'-cyclic phosphodiesterase | 著者 | Wang, H, Robinson, H, Ke, H. | 登録日 | 2010-04-01 | 公開日 | 2010-09-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain. J.Biol.Chem., 285, 2010
|
|
2BPR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2bpr by Molmil](/molmil-images/mine/2bpr) | NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK, 25 STRUCTURES | 分子名称: | DNAK | 著者 | Wang, H, Kurochkin, A.V, Pang, Y, Hu, W, Flynn, G.C, Zuiderweg, E.R.P. | 登録日 | 1998-08-11 | 公開日 | 1999-03-02 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction. Biochemistry, 37, 1998
|
|
4QBS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qbs by Molmil](/molmil-images/mine/4qbs) | |