7NS9
 
 | | Triphosphate tunnel metalloenzyme from Sulfolobus acidocaldarius in complex with triphosphate and calcium | | Descriptor: | ACETATE ION, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Vogt, M.S, Essen, L.-O, Banerjee, A. | | Deposit date: | 2021-03-05 | | Release date: | 2021-06-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | The archaeal triphosphate tunnel metalloenzyme SaTTM defines structural determinants for the diverse activities in the CYTH protein family.
J.Biol.Chem., 297, 2021
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7NSA
 | | Triphosphate tunnel metalloenzyme from Sulfolobus acidocaldarius in complex with pyrophosphate and calcium | | Descriptor: | ACETATE ION, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Vogt, M.S, Essen, L.-O, Banerjee, A. | | Deposit date: | 2021-03-05 | | Release date: | 2021-06-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | The archaeal triphosphate tunnel metalloenzyme SaTTM defines structural determinants for the diverse activities in the CYTH protein family.
J.Biol.Chem., 297, 2021
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7NS8
 | | Triphosphate tunnel metalloenzyme from Sulfolobus acidocaldarius | | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, SULFATE ION, Triphosphate tunnel metalloenzyme Saci_0718 | | Authors: | Vogt, M.S, Essen, L.-O, Banerjee, A. | | Deposit date: | 2021-03-05 | | Release date: | 2021-06-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The archaeal triphosphate tunnel metalloenzyme SaTTM defines structural determinants for the diverse activities in the CYTH protein family.
J.Biol.Chem., 297, 2021
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7NSF
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7NSD
 | | Triphosphate tunnel metalloenzyme from Sulfolobus acidocaldarius in complex with ATP and calcium | | Descriptor: | ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | | Authors: | Vogt, M.S, Essen, L.-O, Banerjee, A. | | Deposit date: | 2021-03-05 | | Release date: | 2021-06-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | The archaeal triphosphate tunnel metalloenzyme SaTTM defines structural determinants for the diverse activities in the CYTH protein family.
J.Biol.Chem., 297, 2021
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7OA2
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1HXV
 | | PPIASE DOMAIN OF THE MYCOPLASMA GENITALIUM TRIGGER FACTOR | | Descriptor: | TRIGGER FACTOR | | Authors: | Vogtherr, M, Parac, T.N, Maurer, M, Pahl, A, Fiebig, K. | | Deposit date: | 2001-01-17 | | Release date: | 2002-05-29 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR solution structure and dynamics of the peptidyl-prolyl cis-trans isomerase domain of the trigger factor from Mycoplasma genitalium compared to FK506-binding protein.
J.Mol.Biol., 318, 2002
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5OW0
 | | Crystal structure of an electron transfer flavoprotein from Geobacter metallireducens | | Descriptor: | ADENOSINE MONOPHOSPHATE, Electron transfer flavoprotein, alpha subunit, ... | | Authors: | Essen, L.-O, Vogt, M.S, Heider, J, Koelzer, S, Peschke, P, Chowdhury, N.P, Schuehle, K, Kleinsorge, D. | | Deposit date: | 2017-08-30 | | Release date: | 2018-10-10 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural and functional characterization of an electron transfer flavoprotein involved in toluene degradation in strictly anaerobic bacteria.
J.Bacteriol., 2019
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6FGJ
 | | Crystal structure of the small alarmone synthethase 2 from Staphylococcus aureus | | Descriptor: | GTP pyrophosphokinase, TRIETHYLENE GLYCOL | | Authors: | Bange, G, Steinchen, W, Vogt, M, Altegoer, F. | | Deposit date: | 2018-01-11 | | Release date: | 2018-02-07 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.251 Å) | | Cite: | Structural and mechanistic divergence of the small (p)ppGpp synthetases RelP and RelQ.
Sci Rep, 8, 2018
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6FGX
 | | Crystal structure of the small alarmone synthethase 2 from Staphylococcus aureus bound to AMPCPP | | Descriptor: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, GTP pyrophosphokinase, MAGNESIUM ION | | Authors: | Bange, G, Vogt, M, Steinchen, W, Altegoer, F. | | Deposit date: | 2018-01-11 | | Release date: | 2018-02-07 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural and mechanistic divergence of the small (p)ppGpp synthetases RelP and RelQ.
Sci Rep, 8, 2018
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6FGK
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6WDT
 | | Enterovirus D68 in complex with human monoclonal antibody EV68-228 | | Descriptor: | EV68-228 heavy chain, EV68-228 light chain, viral protein 1, ... | | Authors: | Fu, J, Vogt, M.R, Klose, T, Crowe, J.E, Rossmann, M.G, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2020-04-01 | | Release date: | 2020-07-15 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease.
Sci Immunol, 5, 2020
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6CMV
 | | Crystal structure of Archaeal Biofilm Regulator (AbfR2) from Sulfolobus acidocaldarius | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, Transcriptional regulator Lrs14-like protein | | Authors: | Essen, L.-O, Vogt, M.S, Banerjee, A. | | Deposit date: | 2018-03-06 | | Release date: | 2018-11-14 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Crystal structure of an Lrs14-like archaeal biofilm regulator from Sulfolobus acidocaldarius.
Acta Crystallogr D Struct Biol, 74, 2018
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6WDS
 | | Enterovirus D68 in complex with human monoclonal antibody EV68-159 | | Descriptor: | EV68-159 heavy chain, EV68-159 light chain, viral protein 1, ... | | Authors: | Fu, J, Klose, T, Vogt, M.R, Crowe, J.E, Rossmann, M.G, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2020-04-01 | | Release date: | 2020-07-15 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease.
Sci Immunol, 5, 2020
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6RY5
 | | Crystal structure of Dfg5 from Chaetomium thermophilum in complex with alpha-1,6-mannobiose | | Descriptor: | CALCIUM ION, Mannan endo-1,6-alpha-mannosidase, TRIETHYLENE GLYCOL, ... | | Authors: | Essen, L.-O, Vogt, M.S. | | Deposit date: | 2019-06-10 | | Release date: | 2020-08-12 | | Last modified: | 2020-09-16 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structural base for the transfer of GPI-anchored glycoproteins into fungal cell walls.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6RY6
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6RY2
 | | Crystal structure of Dfg5 from Chaetomium thermophilum in complex with alpha-1,2-mannobiose | | Descriptor: | ACETATE ION, CALCIUM ION, Mannan endo-1,6-alpha-mannosidase, ... | | Authors: | Essen, L.-O, Vogt, M.S. | | Deposit date: | 2019-06-10 | | Release date: | 2020-08-12 | | Last modified: | 2020-09-16 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structural base for the transfer of GPI-anchored glycoproteins into fungal cell walls.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6RY0
 | | Crystal structure of Dfg5 from Chaetomium thermophilum | | Descriptor: | CALCIUM ION, DIMETHYL SULFOXIDE, Mannan endo-1,6-alpha-mannosidase, ... | | Authors: | Essen, L.-O, Vogt, M.S. | | Deposit date: | 2019-06-10 | | Release date: | 2020-08-12 | | Last modified: | 2020-09-16 | | Method: | X-RAY DIFFRACTION (1.05 Å) | | Cite: | Structural base for the transfer of GPI-anchored glycoproteins into fungal cell walls.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6RY7
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6RY1
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4AJJ
 | | rat LDHA in complex with 2-((3,4-dimethoxyphenyl)methyl))propanedioic acid and N-(2-methyl-1,3-benzothiazol-6-yl)-3-ureido-propanamide | | Descriptor: | 2-((3,4-DIMETHOXYPHENYL)METHYL))PROPANEDIOIC ACID, DIMETHYL SULFOXIDE, GLYCEROL, ... | | Authors: | Tucker, J.A, Brassington, C, Hassall, G, Vogtherr, M, Ward, R, Tart, J, Davies, G, Patel, J, Greenwood, R. | | Deposit date: | 2012-02-16 | | Release date: | 2012-03-21 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation
J.Med.Chem., 55, 2012
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4AJ4
 | | rat LDHA in complex with 4-((2-allylsulfanyl-1,3-benzothizol-6-yl) amino)-4-oxo-butanoic acid | | Descriptor: | 4-oxo-4-{[2-(prop-2-en-1-ylsulfanyl)-1,3-benzothiazol-6-yl]amino}butanoic acid, L-LACTATE DEHYDROGENASE A CHAIN, MALONATE ION | | Authors: | Tucker, J.A, Brassington, C, Hassall, G, Vogtherr, M, Ward, R, Tart, J, Davies, G. | | Deposit date: | 2012-02-15 | | Release date: | 2012-03-21 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation
J.Med.Chem., 55, 2012
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4AJ1
 | | rat LDHA in complex with N-(2-(methylamino)-1,3-benzothiazol-6-yl) acetamide | | Descriptor: | GLYCEROL, L-LACTATE DEHYDROGENASE A CHAIN, MALONATE ION, ... | | Authors: | Tucker, J.A, Brassington, C, Hassall, G, Vogtherr, M, Ward, R, Tart, J, Davies, G. | | Deposit date: | 2012-02-15 | | Release date: | 2012-03-21 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation
J.Med.Chem., 55, 2012
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4AJI
 | | rat LDHA in complex with 2-((3,4-dimethoxyphenyl)methyl))propanedioic acid | | Descriptor: | 2-((3,4-DIMETHOXYPHENYL)METHYL))PROPANEDIOIC ACID, L-LACTATE DEHYDROGENASE A CHAIN | | Authors: | Tucker, J.A, Brassington, C, Hassall, G, Vogtherr, M, Ward, R, Tart, J, Davies, G, Debreczeni, J. | | Deposit date: | 2012-02-16 | | Release date: | 2012-03-21 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation
J.Med.Chem., 55, 2012
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4AJK
 | | rat LDHA in complex with N-(2-(methylamino)-1,3-benzothiazol-6-yl) acetamide | | Descriptor: | GLYCEROL, L-LACTATE DEHYDROGENASE A CHAIN, MALONATE ION, ... | | Authors: | Tucker, J.A, Brassington, C, Hassall, G, Vogtherr, M, Ward, R, Tart, J, Davies, G, Greenwood, R. | | Deposit date: | 2012-02-16 | | Release date: | 2012-03-21 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation
J.Med.Chem., 55, 2012
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