8STG
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2QND
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8SWE
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8U1F
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![BU of 8u1f by Molmil](/molmil-images/mine/8u1f) | FGFR2 Kinase Domain Bound to Irreversible Inhibitor Cmpd 10 | 分子名称: | Fibroblast growth factor receptor 2, GLYCEROL, N-[4-(4-amino-7-methyl-5-{4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-2-methylpropanamide, ... | 著者 | Valverde, R, Foster, L. | 登録日 | 2023-08-31 | 公開日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | 主引用文献 | Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TU6
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![BU of 8tu6 by Molmil](/molmil-images/mine/8tu6) | CryoEM structure of PI3Kalpha | 分子名称: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Valverde, R, Shi, H, Holliday, M. | 登録日 | 2023-08-15 | 公開日 | 2023-11-15 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia. Cancer Discov, 14, 2024
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5TD8
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![BU of 5td8 by Molmil](/molmil-images/mine/5td8) | Crystal structure of an Extended Dwarf Ndc80 Complex | 分子名称: | Kinetochore protein NDC80, Kinetochore protein NUF2, Kinetochore protein SPC24, ... | 著者 | Valverde, R, Ingram, J, Harrison, S.C. | 登録日 | 2016-09-17 | 公開日 | 2016-11-16 | 最終更新日 | 2019-11-20 | 実験手法 | X-RAY DIFFRACTION (7.531 Å) | 主引用文献 | Conserved Tetramer Junction in the Kinetochore Ndc80 Complex. Cell Rep, 17, 2016
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5T6J
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![BU of 5t6j by Molmil](/molmil-images/mine/5t6j) | Structure of the MIND Complex Shows a Regulatory Focus of Yeast Kinetochore Assembly | 分子名称: | Kinetochore protein SPC24, Kinetochore protein SPC25, Kinetochore-associated protein DSN1 | 著者 | Valverde, R, Jenni, S, Dimitrova, Y, Khin, Y, Harrison, S.C. | 登録日 | 2016-09-01 | 公開日 | 2016-11-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.752 Å) | 主引用文献 | Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly. Cell, 167, 2016
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5TCS
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3FWV
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![BU of 3fwv by Molmil](/molmil-images/mine/3fwv) | Crystal Structure of a Redesigned TPR Protein, T-MOD(VMY), in Complex with MEEVF Peptide | 分子名称: | Heat shock protein HSP 90-beta, Hsc70/Hsp90-organizing protein, NICKEL (II) ION | 著者 | Jackrel, M.E, Valverde, R, Regan, L. | 登録日 | 2009-01-19 | 公開日 | 2009-04-21 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Redesign of a protein-peptide interaction: characterization and applications Protein Sci., 18, 2009
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8TSA
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![BU of 8tsa by Molmil](/molmil-images/mine/8tsa) | Human PI3K p85alpha/p110alpha H1047R bound to compound 2 | 分子名称: | 5-(3-bromo-5-fluorobenzamido)-N-methyl-6-(2-methylanilino)pyridine-3-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Holliday, M, Tang, Y, Bulku, A, Wilbur, J, Fraser, J, Valverde, R. | 登録日 | 2023-08-11 | 公開日 | 2023-11-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia. Cancer Discov, 14, 2024
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5T58
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![BU of 5t58 by Molmil](/molmil-images/mine/5t58) | Structure of the MIND Complex Shows a Regulatory Focus of Yeast Kinetochore Assembly | 分子名称: | KLLA0C15939p, KLLA0D15741p, KLLA0E05809p, ... | 著者 | Dimitrova, Y, Jenni, S, Valverde, R, Khin, Y, Harrison, S.C. | 登録日 | 2016-08-30 | 公開日 | 2016-11-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.2131 Å) | 主引用文献 | Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly. Cell, 167, 2016
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5T51
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![BU of 5t51 by Molmil](/molmil-images/mine/5t51) | Structure of the MIND Complex Shows a Regulatory Focus of Yeast Kinetochore Assembly | 分子名称: | KLLA0E05809p, KLLA0F02343p, SULFATE ION | 著者 | Dimitrova, Y, Jenni, S, Valverde, R, Khin, Y, Harrison, S.C. | 登録日 | 2016-08-30 | 公開日 | 2016-11-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.2007 Å) | 主引用文献 | Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly. Cell, 167, 2016
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5T59
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![BU of 5t59 by Molmil](/molmil-images/mine/5t59) | Structure of the MIND Complex Shows a Regulatory Focus of Yeast Kinetochore Assembly | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, KLLA0B13629p, KLLA0E05809p, ... | 著者 | Dimitrova, Y, Jenni, S, Valverde, R, Khin, Y, Harrison, S.C. | 登録日 | 2016-08-30 | 公開日 | 2016-11-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.405 Å) | 主引用文献 | Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly. Cell, 167, 2016
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