4JVG
| B-Raf Kinase in Complex with Birb796 | 分子名称: | 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA, Serine/threonine-protein kinase B-raf | 著者 | Lavoie, H, Thevakumaran, N, Gavory, G, Li, J, Padeganeh, A, Guiral, S, Duchaine, J, Mao, D.Y.L, Bouvier, M, Sicheri, F, Therrien, M. | 登録日 | 2013-03-25 | 公開日 | 2013-05-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. Nat.Chem.Biol., 9, 2013
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5VYK
| Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1 | 分子名称: | Chimera protein of BRS domain of BRAF and CC-SAM domain of KSR1,Serine/threonine-protein kinase B-raf, GLYCEROL | 著者 | Maisonneuve, P, Kurinov, I, Marullo, S.A, Lavoie, H, Thevakumaran, N, Sahmi, M, Jin, T, Therrien, M, SIcheri, F. | 登録日 | 2017-05-25 | 公開日 | 2018-02-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.749 Å) | 主引用文献 | MEK drives BRAF activation through allosteric control of KSR proteins. Nature, 554, 2018
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5VR3
| Crystal structure of the BRS domain of BRAF | 分子名称: | BRAF, SULFATE ION | 著者 | Thevakumaran, N, Maisonneuve, P, Kurinov, I, Lavoie, H, Marullo, S.A, Sahmi, M, Jin, T, Therrien, M, Sicheri, F. | 登録日 | 2017-05-10 | 公開日 | 2018-02-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | 主引用文献 | MEK drives BRAF activation through allosteric control of KSR proteins. Nature, 554, 2018
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