8XEP
| |
5JJG
| Structure of magnesium-loaded ALG-2 | 分子名称: | ISOPROPYL ALCOHOL, MAGNESIUM ION, Pcalcium-binding protein ALG-2, ... | 著者 | Tanner, J.J. | 登録日 | 2016-04-23 | 公開日 | 2016-09-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | EF5 Is the High-Affinity Mg(2+) Site in ALG-2. Biochemistry, 55, 2016
|
|
1BKJ
| NADPH:FMN OXIDOREDUCTASE FROM VIBRIO HARVEYI | 分子名称: | FLAVIN MONONUCLEOTIDE, NADPH-FLAVIN OXIDOREDUCTASE, PHOSPHATE ION | 著者 | Tanner, J.J, Lei, B, TU, S.-C, Krause, K.L. | 登録日 | 1998-07-08 | 公開日 | 1999-01-13 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Flavin reductase P: structure of a dimeric enzyme that reduces flavin. Biochemistry, 35, 1996
|
|
7F3Y
| Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with methotrexate (MTX), NADPH and dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, GLYCEROL, ... | 著者 | Vanichtanankul, J, Tanramluk, D, Yuvaniyama, J, Yuthavong, Y. | 登録日 | 2021-06-17 | 公開日 | 2021-09-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.252 Å) | 主引用文献 | MANORAA: A machine learning platform to guide protein-ligand design by anchors and influential distances. Structure, 30, 2022
|
|
7F3Z
| Double mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-K1, C59R+S108N) complexed with Trimethoprim (TOP), NADPH and dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, GLYCEROL, ... | 著者 | Vanichtanankul, J, Tanramluk, D, Chitnumsub, P, Yuvaniyama, J, Yuthavong, Y. | 登録日 | 2021-06-17 | 公開日 | 2021-09-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | MANORAA: A machine learning platform to guide protein-ligand design by anchors and influential distances. Structure, 30, 2022
|
|
7STB
| Closed state of Rad24-RFC:9-1-1 bound to a 5' ss/dsDNA junction | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DNA (5'-D(P*CP*GP*CP*TP*CP*CP*TP*TP*CP*CP*TP*GP*AP*CP*TP*CP*GP*TP*CP*C)-3'), ... | 著者 | Castaneda, J.C, Schrecker, M, Remus, D, Hite, R.K. | 登録日 | 2021-11-12 | 公開日 | 2022-03-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | 主引用文献 | Mechanisms of loading and release of the 9-1-1 checkpoint clamp. Nat.Struct.Mol.Biol., 29, 2022
|
|
7ST9
| Open state of Rad24-RFC:9-1-1 bound to a 5' ss/dsDNA junction | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DNA (5'-D(P*CP*GP*CP*TP*CP*CP*TP*TP*CP*CP*TP*GP*AP*CP*TP*CP*GP*TP*CP*C)-3'), ... | 著者 | Castaneda, J.C, Schrecker, M, Remus, D, Hite, R.K. | 登録日 | 2021-11-12 | 公開日 | 2022-03-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Mechanisms of loading and release of the 9-1-1 checkpoint clamp. Nat.Struct.Mol.Biol., 29, 2022
|
|
3DYC
| |
3NN2
| Structure of chlorite dismutase from Candidatus Nitrospira defluvii in complex with cyanide | 分子名称: | CYANIDE ION, Chlorite dismutase, GLYCEROL, ... | 著者 | Kostan, J, Sjoeblom, B, Maixner, F, Mlynek, G, Furtmueller, P.G, Obinger, C, Wagner, M, Daims, H, Djinovic-Carugo, K. | 登録日 | 2010-06-23 | 公開日 | 2010-07-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structural and functional characterisation of the chlorite dismutase from the nitrite-oxidizing bacterium "Candidatus Nitrospira defluvii": Identification of a catalytically important amino acid residue J.Struct.Biol., 172, 2010
|
|
4Q73
| Crystal Structure of Bradyrhizobium japonicum Proline Utilization A (PutA) Mutant D778Y | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Proline dehydrogenase, ... | 著者 | Tanner, J.J, Luo, M, Pemberton, T.A. | 登録日 | 2014-04-23 | 公開日 | 2014-08-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Kinetic and Structural Characterization of Tunnel-Perturbing Mutants in Bradyrhizobium japonicum Proline Utilization A. Biochemistry, 53, 2014
|
|
5CDH
| |
6JLV
| Near-Atomic Resolution Structure of the CYP102A1 Haem Domain with N-Abietoyl-L-Tryptophan | 分子名称: | (2S)-2-[[(1R,4aR,4bR,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthren-1-yl]carbonylamino]-3-( 1H-indol-3-yl)propanoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bifunctional cytochrome P450/NADPH--P450 reductase, ... | 著者 | Stanfield, J.K, Kasai, C, Sugimoto, H, Shiro, Y, Watanabe, Y, Shoji, O. | 登録日 | 2019-03-07 | 公開日 | 2020-03-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | 主引用文献 | Crystals in Minutes: Instant On-Site Microcrystallisation of Various Flavours of the CYP102A1 (P450BM3) Haem Domain. Angew.Chem.Int.Ed.Engl., 59, 2020
|
|
6JMW
| Structure of the Chromium Protoporphyrin IX-Reconstituted CYP102A1 Haem Domain with N-Abietoyl-L-Tryptophan | 分子名称: | (2S)-2-[[(1R,4aR,4bR,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthren-1-yl]carbonylamino]-3-( 1H-indol-3-yl)propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, Chromium Protoporphyrin IX, ... | 著者 | Stanfield, J.K, Omura, K, Kasai, C, Sugimoto, H, Shiro, Y, Watanabe, Y, Shoji, O. | 登録日 | 2019-03-13 | 公開日 | 2020-03-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystals in Minutes: Instant On-Site Microcrystallisation of Various Flavours of the CYP102A1 (P450BM3) Haem Domain. Angew.Chem.Int.Ed.Engl., 59, 2020
|
|
7SQN
| |
5CKU
| |
7STE
| Rad24-RFC ADP state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Checkpoint protein RAD24, ... | 著者 | Castaneda, J.C, Schrecker, M, Remus, D, Hite, R.K. | 登録日 | 2021-11-12 | 公開日 | 2022-04-06 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | 主引用文献 | Mechanisms of loading and release of the 9-1-1 checkpoint clamp. Nat.Struct.Mol.Biol., 29, 2022
|
|
7FGX
| Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with P39, NADPH and dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 6-hexyl-5-phenyl-pyrimidine-2,4-diamine, Bifunctional dihydrofolate reductase-thymidylate synthase, ... | 著者 | Vanichtanankul, J, Yoomuang, A, Taweechai, S, Saeyang, T, Yuvaniyama, J, Tarnchompoo, B, Yuthavong, Y, Kamchonwongpaisan, S. | 登録日 | 2021-07-28 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase. Acs Chem.Biol., 17, 2022
|
|
7FGY
| Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with P40, NADPH and dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(3-chlorophenyl)-6-[2-(3-phenoxypropoxy)ethyl]pyrimidine-2,4-diamine, Bifunctional dihydrofolate reductase-thymidylate synthase, ... | 著者 | Vanichtanankul, J, Yoomuang, A, Taweechai, S, Saeyang, T, Yuvaniyama, J, Tarnchompoo, B, Yuthavong, Y, Kamchonwongpaisan, S. | 登録日 | 2021-07-28 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase. Acs Chem.Biol., 17, 2022
|
|
2W2G
| Human SARS coronavirus unique domain | 分子名称: | NON-STRUCTURAL PROTEIN 3, SULFATE ION | 著者 | Tan, J, Vonrhein, C, Smart, O.S, Bricogne, G, Bollati, M, Kusov, Y, Hansen, G, Mesters, J.R, Schmidt, C.L, Hilgenfeld, R. | 登録日 | 2008-10-30 | 公開日 | 2009-05-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | The Sars-Unique Domain (Sud) of Sars Coronavirus Contains Two Macrodomains that Bind G-Quadruplexes. Plos Pathog., 5, 2009
|
|
7FGW
| Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with pyrimethamine, NADPH and dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, BENZAMIDINE, ... | 著者 | Vanichtanankul, J, Yoomuang, A, Taweechai, S, Saeyang, T, Yuvaniyama, Y, Tarnchompoo, B, Yuthavong, Y, Kamchonwongpaisan, S. | 登録日 | 2021-07-28 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase. Acs Chem.Biol., 17, 2022
|
|
2WCT
| human SARS coronavirus unique domain (triclinic form) | 分子名称: | NON-STRUCTURAL PROTEIN 3 | 著者 | Tan, J, Vonrhein, C, Smart, O.S, Bricogne, G, Bollati, M, Hansen, G, Mesters, J.R, Hilgenfeld, R. | 登録日 | 2009-03-16 | 公開日 | 2009-05-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | The Sars-Unique Domain (Sud) of Sars Coronavirus Contains Two Macrodomains that Bind G-Quadruplexes. Plos Pathog., 5, 2009
|
|
8HFE
| Cryo-EM structure of human norepinephrine transporter NET in an inward-open state at resolution of 2.5 angstrom | 分子名称: | CHLORIDE ION, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-11-10 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
|
|
8HFF
| Cryo-EM structure of human norepinephrine transporter NET in the presence of norepinephrine in an inward-open state at resolution of 2.9 angstrom. | 分子名称: | L-NOREPINEPHRINE, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-11-10 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
|
|
8HFL
| Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant bupropion in an inward-open state at resolution of 3.0 angstrom. | 分子名称: | Bupropion, CHLORIDE ION, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-11-11 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
|
|
8HFI
| Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant desipramine in an inward-open state at resolution of 2.5 angstrom. | 分子名称: | 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-11-10 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
|
|