7RMD
| Crystal structure of the first bromodomain of human BRD4 in complex with SJ001011461-1 | Descriptor: | 1,2-ETHANEDIOL, 2-[(6S,10R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(1,3,4-thiadiazol-2-yl)acetamide, Bromodomain-containing protein 4 | Authors: | Stachowski, T.R, Fischer, M. | Deposit date: | 2021-07-27 | Release date: | 2022-08-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors. Eur.J.Med.Chem., 251, 2023
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7RD6
| Structure of the S. cerevisiae P4B ATPase lipid flippase in the E2P state | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, Probable phospholipid-transporting ATPase NEO1 | Authors: | Bai, L, Jain, B.K, You, Q, Duan, H.D, Graham, T.R, Li, H. | Deposit date: | 2021-07-09 | Release date: | 2021-09-29 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structural basis of the P4B ATPase lipid flippase activity. Nat Commun, 12, 2021
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7RD8
| Structure of the S. cerevisiae P4B ATPase lipid flippase in the E1-ATP state | Descriptor: | MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Probable phospholipid-transporting ATPase NEO1 | Authors: | Bai, L, Jain, B.K, You, Q, Duan, H.D, Graham, T.R, Li, H. | Deposit date: | 2021-07-09 | Release date: | 2021-09-29 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (5.64 Å) | Cite: | Structural basis of the P4B ATPase lipid flippase activity. Nat Commun, 12, 2021
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7RD7
| Structure of the S. cerevisiae P4B ATPase lipid flippase in the E2P-transition state | Descriptor: | MAGNESIUM ION, Probable phospholipid-transporting ATPase NEO1, TETRAFLUOROALUMINATE ION | Authors: | Bai, L, Jain, B.K, You, Q, Duan, H.D, Graham, T.R, Li, H. | Deposit date: | 2021-07-09 | Release date: | 2021-09-29 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structural basis of the P4B ATPase lipid flippase activity. Nat Commun, 12, 2021
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7QFZ
| BrxR, a WYL-domain containing transcriptional regulator | Descriptor: | SULFATE ION, WYL domain-containing protein | Authors: | Picton, D.M, Blower, T.R. | Deposit date: | 2021-12-07 | Release date: | 2022-05-18 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands. Nucleic Acids Res., 50, 2022
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7QFN
| Human Topoisomerase II Beta ATPase ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA topoisomerase 2-beta, MAGNESIUM ION, ... | Authors: | Ling, E.M, Basle, A, Cowell, I.G, Blower, T.R, Austin, C.A. | Deposit date: | 2021-12-06 | Release date: | 2022-05-25 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.621 Å) | Cite: | A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193. Structure, 30, 2022
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7QFO
| Human Topoisomerase II Beta ATPase AMPPNP | Descriptor: | ALANINE, DNA topoisomerase 2-beta, MAGNESIUM ION, ... | Authors: | Ling, E.M, Basle, A, Cowell, I.G, Blower, T.R, Austin, C.A. | Deposit date: | 2021-12-06 | Release date: | 2022-05-25 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193. Structure, 30, 2022
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7S5B
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7S2V
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7S27
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7S29
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7S2C
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7S30
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7S33
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7S2W
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7S2A
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7S28
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7S2B
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7S2F
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7S32
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7S2G
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7S34
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7S2D
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7S2U
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7S2E
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