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PDB: 290 results

6Q14
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Structure of the Salmonella SPI-1 injectisome NC-base
Descriptor: Lipoprotein PrgK, Protein InvG, Protein PrgH, ...
Authors:Hu, J, Worrall, L.J, Strynadka, N.C.J.
Deposit date:2019-08-02
Release date:2019-10-23
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly.
Nat Microbiol, 4, 2019
6Q16
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Focussed refinement of InvGN0N1:PrgHK:SpaPQR:PrgIJ from Salmonella SPI-1 injectisome NC-base
Descriptor: Lipoprotein PrgK, Protein InvG, Protein PrgH, ...
Authors:Hu, J, Worrall, L.J, Strynadka, N.C.J.
Deposit date:2019-08-02
Release date:2019-10-23
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly.
Nat Microbiol, 4, 2019
7JOY
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BU of 7joy by Molmil
Product structure of SARS-CoV-2 Mpro C145A mutant in complex with its C-terminal autoprocessing sequence.
Descriptor: 3C-like proteinase
Authors:Lee, J, Worrall, L.J, Paetzel, M, Strynadka, N.C.J.
Deposit date:2020-08-07
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site.
Nat Commun, 11, 2020
7JP1
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Structure of wild-type substrate free SARS-CoV-2 Mpro.
Descriptor: 3C-like proteinase
Authors:Lee, J, Worrall, L.J, Paetzel, M, Strynadka, N.C.J.
Deposit date:2020-08-07
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site.
Nat Commun, 11, 2020
7JLR
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BU of 7jlr by Molmil
Crystal structure of Bacillus subtilis UppS in complex with JPD447
Descriptor: 7-(azepan-1-yl)-5-ethyl-3-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine, Isoprenyl transferase
Authors:Workman, S.D, Strynadka, N.C.J.
Deposit date:2020-07-30
Release date:2021-08-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria.
J.Med.Chem., 64, 2021
7JLI
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Crystal structure of Bacillus subtilis UppS
Descriptor: DI(HYDROXYETHYL)ETHER, Isoprenyl transferase
Authors:Workman, S.D, Strynadka, N.C.J.
Deposit date:2020-07-29
Release date:2021-08-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria.
J.Med.Chem., 64, 2021
7JLM
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Crystal structure of Bacillus subtilis UppS in complex with MAC-0547630
Descriptor: 7-(azepan-1-yl)-3-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidine, CITRIC ACID, Isoprenyl transferase
Authors:Workman, S.D, Strynadka, N.C.J.
Deposit date:2020-07-29
Release date:2021-08-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria.
J.Med.Chem., 64, 2021
7JLJ
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Crystal structure of Bacillus subtilis UppS in complex with clomiphene
Descriptor: Clomifene, Isoprenyl transferase
Authors:Workman, S.D, Strynadka, N.C.J.
Deposit date:2020-07-29
Release date:2021-08-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria.
J.Med.Chem., 64, 2021
1KN9
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BU of 1kn9 by Molmil
CRYSTAL STRUCTURE OF A BACTERIAL SIGNAL PEPTIDASE APO-ENZYME, IMPLICATIONS FOR SIGNAL PEPTIDE BINDING AND THE SER-LYS DYAD MECHANISM.
Descriptor: Signal peptidase I
Authors:Paetzel, M, Dalbey, R.E, Strynadka, N.C.J.
Deposit date:2001-12-18
Release date:2002-01-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of a bacterial signal peptidase apoenzyme: implications for signal peptide binding and the Ser-Lys dyad mechanism
J.Biol.Chem., 277, 2002
4G1I
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BU of 4g1i by Molmil
Structure of the PrgH periplasmic domain
Descriptor: PENTAETHYLENE GLYCOL, PHOSPHATE ION, Protein prgH
Authors:Bergeron, J.R.C, Worrall, L.J, Strynadka, N.C.J.
Deposit date:2012-07-10
Release date:2013-05-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly.
Plos Pathog., 9, 2013
4J94
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BU of 4j94 by Molmil
Crystal structure of MycP1 from the ESX-1 type VII secretion system
Descriptor: Membrane-anchored mycosin mycp1
Authors:Solomonson, M, Wasney, G.A, Watanabe, N, Gruninger, R.J, Prehna, G, Strynadka, N.C.J.
Deposit date:2013-02-15
Release date:2013-05-01
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.857 Å)
Cite:Structure of the Mycosin-1 Protease from the Mycobacterial ESX-1 Protein Type VII Secretion System.
J.Biol.Chem., 288, 2013
4KPG
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Crystal structure of MycP1 from the ESX-1 type VII secretion system
Descriptor: Membrane-anchored mycosin mycp1
Authors:Solomonson, M, Wasney, G.A, Watanabe, N, Gruninger, R.J, Prehna, G, Strynadka, N.C.J.
Deposit date:2013-05-13
Release date:2013-05-22
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.148 Å)
Cite:Structure of the Mycosin-1 Protease from the Mycobacterial ESX-1 Protein Type VII Secretion System.
J.Biol.Chem., 288, 2013
6N7O
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BU of 6n7o by Molmil
Crystal structure of GIL01 gp7
Descriptor: GIL01 gp7, IODIDE ION
Authors:Caveney, N.A, Strynadka, N.C.J.
Deposit date:2018-11-27
Release date:2019-05-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insights into Bacteriophage GIL01 gp7 Inhibition of Host LexA Repressor.
Structure, 27, 2019
6NJP
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BU of 6njp by Molmil
Structure of the assembled ATPase EscN in complex with its central stalk EscO from the enteropathogenic E. coli (EPEC) type III secretion system
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, EscO, ...
Authors:Majewski, D.D, Worrall, L.J, Hong, C, Atkinson, C.E, Vuckovic, M, Watanabe, N, Yu, Z, Strynadka, N.C.J.
Deposit date:2019-01-03
Release date:2019-02-20
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry.
Nat Commun, 10, 2019
6NJO
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Structure of the assembled ATPase EscN from the enteropathogenic E. coli (EPEC) type III secretion system
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ...
Authors:Majewski, D.D, Worrall, L.J, Hong, C, Atkinson, C.E, Vuckovic, M, Watanabe, N, Yu, Z, Strynadka, N.C.J.
Deposit date:2019-01-03
Release date:2019-02-20
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry.
Nat Commun, 10, 2019
6NTZ
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BU of 6ntz by Molmil
Crystal structure of E. coli PBP5-meropenem
Descriptor: (2S,3R,4S)-4-{[(3S,5R)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, D-alanyl-D-alanine carboxypeptidase
Authors:Caveney, N.A, Strynadka, N.C.J, Caballero, G, Worrall, L.J.
Deposit date:2019-01-30
Release date:2019-03-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli.
Nat Commun, 10, 2019
6NTW
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BU of 6ntw by Molmil
Crystal structure of E. coli YcbB
Descriptor: (2S,3R,4S)-4-{[(3S,5R)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Probable L,D-transpeptidase YcbB, SULFATE ION
Authors:Caveney, N.A, Strynadka, N.C.J, Caballero, G, Worrall, L.J.
Deposit date:2019-01-30
Release date:2019-03-20
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli.
Nat Commun, 10, 2019
6O9S
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BU of 6o9s by Molmil
Crystal structure of Staphylococcus aureus MecR1 antibiotic-sensor domain in complex with avibactam
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Methicillin resistance mecR1 protein, SULFATE ION
Authors:Alexander, J.A.N, Strynadka, N.C.J.
Deposit date:2019-03-14
Release date:2020-06-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus .
J.Biol.Chem., 295, 2020
6O9W
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BU of 6o9w by Molmil
Crystal structure of Staphylococcus aureus BlaR1 antibiotic-sensor domain in complex with avibactam
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Regulatory protein BlaR1
Authors:Alexander, J.A.N, Strynadka, N.C.J.
Deposit date:2019-03-15
Release date:2020-06-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus .
J.Biol.Chem., 295, 2020
2JW1
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BU of 2jw1 by Molmil
Structural characterization of the type III pilotin-secretin interaction in Shigella flexneri by NMR spectroscopy
Descriptor: Lipoprotein mxiM, Outer membrane protein mxiD
Authors:Okon, M.S, Lario, P.I, Creagh, L, Jung, Y.M.T, Maurelli, A.T, Strynadka, N.C.J, McIntosh, L.P.
Deposit date:2007-10-02
Release date:2008-09-02
Last modified:2020-02-19
Method:SOLUTION NMR
Cite:Structural Characterization of the Type-III Pilot-Secretin Complex from Shigella flexneri
Structure, 16, 2008
2LQV
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BU of 2lqv by Molmil
YebF
Descriptor: Protein yebF
Authors:Prehna, G, Zhang, G, Gong, X, Duszyk, M, Okon, M, Mcintosh, L.P, Weiner, J.H, Strynadka, N.C.J.
Deposit date:2012-03-16
Release date:2012-06-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A Protein Export Pathway Involving Escherichia coli Porins.
Structure, 20, 2012
2LV4
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BU of 2lv4 by Molmil
ZirS C-terminal Domain
Descriptor: Putative outer membrane or exported protein
Authors:Prehna, G, Li, Y, Stoynov, N, Okon, M, Vukovic, M, Mcintosh, L.P, Foster, L.J, Finlay, B, Strynadka, N.C.J.
Deposit date:2012-06-28
Release date:2012-08-22
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The zinc regulated antivirulence pathway of salmonella is a multiprotein immunoglobulin adhesion system.
J.Biol.Chem., 287, 2012
5C9E
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BU of 5c9e by Molmil
SepL
Descriptor: BROMIDE ION, SepL
Authors:Burkinshaw, B.J, Strynadka, N.C.J.
Deposit date:2015-06-26
Release date:2015-10-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Structural analysis of SepL, an enteropathogenic Escherichia coli type III secretion system gatekeeper protein
Acta Crystallogr.,Sect.F, 71, 2015
5CXY
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BU of 5cxy by Molmil
Structure of a Glycosyltransferase in Complex with Inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Volkers, G, Strynadka, N.C.J.
Deposit date:2015-07-29
Release date:2016-09-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:To be published.
To be published
2FFF
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BU of 2fff by Molmil
Open Form of a Class A Transpeptidase Domain
Descriptor: NICKEL (II) ION, penicillin-binding protein 1B
Authors:Lovering, A.L, Strynadka, N.C.J.
Deposit date:2005-12-19
Release date:2006-06-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structural analysis of an "open" form of PBP1B from Streptococcus pneumoniae.
Protein Sci., 15, 2006

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