1RA0
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![BU of 1ra0 by Molmil](/molmil-images/mine/1ra0) | Bacterial cytosine deaminase D314G mutant bound to 5-fluoro-4-(S)-hydroxy-3,4-dihydropyrimidine. | Descriptor: | (4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE, Cytosine deaminase, FE (III) ION | Authors: | Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E. | Deposit date: | 2003-10-31 | Release date: | 2004-10-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy. Protein Eng.Des.Sel., 17, 2004
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1RAK
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![BU of 1rak by Molmil](/molmil-images/mine/1rak) | Bacterial cytosine deaminase D314S mutant bound to 5-fluoro-4-(S)-hydroxyl-3,4-dihydropyrimidine. | Descriptor: | (4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE, Cytosine deaminase, FE (III) ION, ... | Authors: | Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E. | Deposit date: | 2003-10-31 | Release date: | 2004-10-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy. Protein Eng.Des.Sel., 17, 2004
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1UJZ
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![BU of 1ujz by Molmil](/molmil-images/mine/1ujz) | Crystal structure of the E7_C/Im7_C complex; a computationally designed interface between the colicin E7 DNase and the Im7 Immunity protein | Descriptor: | Designed Colicin E7 DNase, Designed Colicin E7 immunity protein | Authors: | Kortemme, T, Joachimiak, L.A, Bullock, A.N, Schuler, A.D, Stoddard, B.L, Baker, D. | Deposit date: | 2003-08-13 | Release date: | 2004-04-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Computational redesign of protein-protein interaction specificity NAT.STRUCT.MOL.BIOL., 11, 2004
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1U0C
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![BU of 1u0c by Molmil](/molmil-images/mine/1u0c) | Y33C Mutant of Homing endonuclease I-CreI | Descriptor: | 5'-D(*CP*GP*TP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*AP*GP*C)-3', 5'-D(*GP*CP*TP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*AP*CP*G)-3', DNA endonuclease I-CreI, ... | Authors: | Sussman, D, Chadsey, M, Fauce, S, Engel, A, Bruett, A, Monnat, R, Stoddard, B.L, Seligman, L.M. | Deposit date: | 2004-07-13 | Release date: | 2004-11-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Isolation and characterization of new homing endonuclease specificities at individual target site positions. J.Mol.Biol., 342, 2004
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1RRC
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![BU of 1rrc by Molmil](/molmil-images/mine/1rrc) | T4 POLYNUCLEOTIDE KINASE BOUND TO 5'-GTC-3' SSDNA | Descriptor: | 5'-D(*GP*TP*C)-3', ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | Authors: | Eastberg, J.H, Pelletier, J, Stoddard, B.L. | Deposit date: | 2003-12-08 | Release date: | 2004-02-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Recognition of DNA substrates by T4 bacteriophage polynucleotide kinase. Nucleic Acids Res., 32, 2004
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1T9I
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![BU of 1t9i by Molmil](/molmil-images/mine/1t9i) | I-CreI(D20N)/DNA complex | Descriptor: | 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*C)-3', 5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP*CP*G)-3', CALCIUM ION, ... | Authors: | Chevalier, B, Sussman, D, Otis, C, Boudreau, D, Turmel, M, Lemieux, C, Stephens, K, Monnat Jr, R.J, Stoddard, B.L. | Deposit date: | 2004-05-17 | Release date: | 2004-11-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Metal-Dependent DNA Cleavage Mechanism of the I-CreI LAGLIDADG Homing Endonuclease. Biochemistry, 43, 2004
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1T9J
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![BU of 1t9j by Molmil](/molmil-images/mine/1t9j) | I-CreI(Q47E)/DNA complex | Descriptor: | 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*C)-3', 5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP*CP*G)-3', DNA endonuclease I-CreI | Authors: | Chevalier, B, Sussman, D, Otis, C, Boudreau, D, Turmel, M, Lemieux, C, Stephens, K, Monnat Jr, R.J, Stoddard, B.L. | Deposit date: | 2004-05-17 | Release date: | 2004-11-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Metal-Dependent DNA Cleavage Mechanism of the I-CreI LAGLIDADG Homing Endonuclease. Biochemistry, 43, 2004
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7JTA
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![BU of 7jta by Molmil](/molmil-images/mine/7jta) | Crystal structure of a putative nuclease with anti-Cas9 activity from an uncultured Clostridia bacterium | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, NITRATE ION, NTF2-like nuclease/anti-CRISPR | Authors: | Werther, R, Forsberg, K.J, Stoddard, B.L. | Deposit date: | 2020-08-17 | Release date: | 2021-09-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.801 Å) | Cite: | The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity. Plos Biol., 19, 2021
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7LO5
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![BU of 7lo5 by Molmil](/molmil-images/mine/7lo5) | cryoEM structure DrdV-DNA complex | Descriptor: | CALCIUM ION, DNA (27-MER), DNA (28-MER), ... | Authors: | Shen, B.W, Stoddard, B.L. | Deposit date: | 2021-02-09 | Release date: | 2021-03-17 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM. Structure, 29, 2021
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7LVV
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![BU of 7lvv by Molmil](/molmil-images/mine/7lvv) | cryoEM structure DrdV-DNA complex | Descriptor: | CALCIUM ION, DNA (27-MER), DNA (28-MER), ... | Authors: | Shen, B.W, Stoddard, B.L. | Deposit date: | 2021-02-26 | Release date: | 2021-03-17 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM. Structure, 29, 2021
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5BVB
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![BU of 5bvb by Molmil](/molmil-images/mine/5bvb) | Engineered Digoxigenin binder DIG5.1a | Descriptor: | DIG5.1a, DIGOXIGENIN | Authors: | Doyle, L.A, Stoddard, B.L. | Deposit date: | 2015-06-04 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | CSAR Benchmark Exercise 2013: Evaluation of Results from a Combined Computational Protein Design, Docking, and Scoring/Ranking Challenge. J.Chem.Inf.Model., 56, 2016
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