2AIA
| S.pneumoniae PDF complexed with SB-543668 | Descriptor: | 2-(3-BENZOYLPHENOXY)ETHYL(HYDROXY)FORMAMIDE, NICKEL (II) ION, Peptide deformylase, ... | Authors: | Smith, K.J, Petit, C.M, Aubart, K, Smyth, M, McManus, E, Jones, J, Fosberry, A, Lewis, C, Lonetto, M, Christensen, S.B. | Deposit date: | 2005-07-29 | Release date: | 2005-09-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Variation and inhibitor binding in polypeptide deformylase from four different bacterial species. Protein Sci., 12, 2003
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7RG4
| Importin alpha2 in complex with p50 NLS | Descriptor: | Importin subunit alpha-1, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit | Authors: | Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K. | Deposit date: | 2021-07-14 | Release date: | 2021-08-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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7RG5
| Importin alpha3 in complex with p50 NLS | Descriptor: | Importin subunit alpha-3, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit | Authors: | Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K. | Deposit date: | 2021-07-14 | Release date: | 2021-08-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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5KLT
| Prototypical P4[M]cNLS | Descriptor: | Importin subunit alpha-1, Prototypical P4[M]cNLS | Authors: | Smith, K.M, Forwood, J.K. | Deposit date: | 2016-06-25 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting. Biochim Biophys Acta Mol Cell Res, 1865, 2018
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5KLR
| Prototypical P4[R]cNLS | Descriptor: | Importin subunit alpha-1, Prototypical P4[R]cNLS | Authors: | Smith, K.M, Forwood, J.K. | Deposit date: | 2016-06-25 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting. Biochim Biophys Acta Mol Cell Res, 1865, 2018
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6D71
| Crystal Structure of the Human Miro1 N-terminal GTPase bound to GTP | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mitochondrial Rho GTPase 1 | Authors: | Smith, K.P, Focia, P.J, Rice, S.E, Freymann, D.M. | Deposit date: | 2018-04-23 | Release date: | 2019-10-09 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.7180779 Å) | Cite: | Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase. J.Struct.Biol., 212, 2020
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1VZO
| The structure of the N-terminal kinase domain of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein | Descriptor: | BETA-MERCAPTOETHANOL, RIBOSOMAL PROTEIN S6 KINASE ALPHA 5, SULFATE ION | Authors: | Smith, K.J, Carter, P.S, Bridges, A, Horrocks, P, Lewis, C, Pettman, G, Clarke, A, Brown, M, Hughes, J, Wilkinson, M, Bax, B, Reith, A. | Deposit date: | 2004-05-21 | Release date: | 2004-06-11 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Structure of Msk1 Reveals a Novel Autoinhibitory Conformation for a Dual Kinase Protein Structure, 12, 2004
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3UD4
| The C92U mutant c-di-GMP-I riboswitch bound to GpA | Descriptor: | MAGNESIUM ION, RNA (5'-R(*GP*A)-3'), RNA (92-MER), ... | Authors: | Smith, K.D, Strobel, S.A. | Deposit date: | 2011-10-27 | Release date: | 2012-01-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural and biochemical characterization of linear dinucleotide analogues bound to the c-di-GMP-I aptamer. Biochemistry, 51, 2012
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3UD3
| The C92U mutant c-di-GMP-I riboswitch bound to pGpA | Descriptor: | MAGNESIUM ION, RNA (5'-R(P*GP*A)-3'), RNA (92-MER), ... | Authors: | Smith, K.D, Strobel, S.A. | Deposit date: | 2011-10-27 | Release date: | 2012-01-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural and biochemical characterization of linear dinucleotide analogues bound to the c-di-GMP-I aptamer. Biochemistry, 51, 2012
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3UCZ
| The c-di-GMP-I riboswitch bound to GpG | Descriptor: | MAGNESIUM ION, RNA (5'-R(*GP*G)-3'), RNA (92-MER), ... | Authors: | Smith, K.D, Strobel, S.A. | Deposit date: | 2011-10-27 | Release date: | 2012-01-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and biochemical characterization of linear dinucleotide analogues bound to the c-di-GMP-I aptamer. Biochemistry, 51, 2012
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3UCU
| The c-di-GMP-I riboswitch bound to pGpG | Descriptor: | MAGNESIUM ION, RNA (92-MER), U1 small nuclear ribonucleoprotein A, ... | Authors: | Smith, K.D, Strobel, S.A. | Deposit date: | 2011-10-27 | Release date: | 2012-01-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and biochemical characterization of linear dinucleotide analogues bound to the c-di-GMP-I aptamer. Biochemistry, 51, 2012
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6BVZ
| Importin alpha 3 in cargo free state | Descriptor: | Importin subunit alpha-3 | Authors: | Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. | Deposit date: | 2017-12-14 | Release date: | 2018-07-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
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4G38
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4G39
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6BVT
| Importin alpha 1 in cargo free state | Descriptor: | Importin subunit alpha-1 | Authors: | Smith, K.M, Tsimablyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. | Deposit date: | 2017-12-13 | Release date: | 2018-07-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
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6BW0
| Nipah virus W protein C-terminus in complex with Importin alpha 1 | Descriptor: | Importin subunit alpha-1, Protein W | Authors: | Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. | Deposit date: | 2017-12-14 | Release date: | 2018-07-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
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6BVV
| Nipah virus W protein C-terminus in complex with Importin alpha 3 | Descriptor: | Importin subunit alpha-3, Protein W | Authors: | Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. | Deposit date: | 2017-12-13 | Release date: | 2018-07-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
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4HTR
| N149W variant of SiRHP bound to sulfite | Descriptor: | IRON/SULFUR CLUSTER, SIROHEME, SODIUM ION, ... | Authors: | Smith, K.W, Stroupe, M.E. | Deposit date: | 2012-11-01 | Release date: | 2013-01-16 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Mutational analysis of sulfite reductase hemoprotein reveals the mechanism for coordinated electron and proton transfer. Biochemistry, 51, 2012
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1LOI
| N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE, NMR, 7 STRUCTURES | Descriptor: | CYCLIC 3',5'-AMP SPECIFIC PHOSPHODIESTERASE RD1 | Authors: | Smith, K.J, Scotland, G, Beattie, J, Trayer, I.P, Houslay, M.D. | Deposit date: | 1996-05-21 | Release date: | 1997-05-15 | Last modified: | 2024-10-23 | Method: | SOLUTION NMR | Cite: | Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs. J.Biol.Chem., 271, 1996
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1BX2
| CRYSTAL STRUCTURE OF HLA-DR2 (DRA*0101,DRB1*1501) COMPLEXED WITH A PEPTIDE FROM HUMAN MYELIN BASIC PROTEIN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (HLA-DR2) | Authors: | Smith, K.J, Pyrdol, J, Gauthier, L, Wiley, D.C, Wucherpfennig, K. | Deposit date: | 1998-10-12 | Release date: | 1998-10-21 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein. J.Exp.Med., 188, 1998
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1A1O
| MHC CLASS I MOLECULE B*5301 COMPLEXED WITH PEPTIDE LS6 (KPIVQYDNF) FROM THE MALARIA PARASITE P. FALCIPARUM | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, BW-53 B*5301 alpha chain, ... | Authors: | Smith, K.J, Reid, S.W, Harlos, K, Mcmichael, A.J, Stuart, D.I, Bell, J.I, Jones, E.Y. | Deposit date: | 1997-12-11 | Release date: | 1998-04-08 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53. Immunity, 4, 1996
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1A1M
| MHC CLASS I MOLECULE B*5301 COMPLEXED WITH PEPTIDE TPYDINQML FROM GAG PROTEIN OF HIV2 | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, BW-53 B*5301 alpha chain, ... | Authors: | Smith, K.J, Reid, S.W, Harlos, K, Mcmichael, A.J, Stuart, D.I, Bell, J.I, Jones, E.Y. | Deposit date: | 1997-12-11 | Release date: | 1998-04-08 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53. Immunity, 4, 1996
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1A1N
| MHC CLASS I MOLECULE B*3501 COMPLEXED WITH PEPTIDE VPLRPMTY FROM THE NEF PROTEIN (75-82) OF HIV1 | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, BW-53 B*5301 alpha chain, ... | Authors: | Smith, K.J, Reid, S.W, Stuart, D.I, Mcmichael, A.J, Jones, E.Y, Bell, J.I. | Deposit date: | 1997-12-11 | Release date: | 1998-04-08 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | An altered position of the alpha 2 helix of MHC class I is revealed by the crystal structure of HLA-B*3501. Immunity, 4, 1996
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5HHG
| Mouse importin alpha: Dengue 2 NS5 C-terminal NLS peptide complex | Descriptor: | Importin subunit alpha-1, RNA-directed RNA polymerase NS5 | Authors: | Smith, K.M, Forwood, J.K. | Deposit date: | 2016-01-11 | Release date: | 2016-05-18 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production. PLoS Pathog., 12, 2016
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5FC8
| Mouse importin alpha: Dengue 3 NS5 C-terminal NLS peptide complex | Descriptor: | Importin subunit alpha-1, Nonstructural protein 5 | Authors: | Smith, K.M, Forwood, J.K. | Deposit date: | 2015-12-15 | Release date: | 2016-05-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production. PLoS Pathog., 12, 2016
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