1GUH
 
 | | Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the MU and PI class enzymes | | Descriptor: | GLUTATHIONE S-TRANSFERASE A1-1, S-BENZYL-GLUTATHIONE | | Authors: | Sinning, I, Kleywegt, G.J, Jones, T.A. | | Deposit date: | 1993-02-24 | | Release date: | 1993-10-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes.
J.Mol.Biol., 232, 1993
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1SUR
 | | PHOSPHO-ADENYLYL-SULFATE REDUCTASE | | Descriptor: | PAPS REDUCTASE | | Authors: | Sinning, I, Savage, H. | | Deposit date: | 1998-04-01 | | Release date: | 1999-05-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of phosphoadenylyl sulphate (PAPS) reductase: a new family of adenine nucleotide alpha hydrolases.
Structure, 5, 1997
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8ODU
 | | Chaetomium thermophilum Get1/Get2 heterotetramer in complex with a Get3 dimer (amphipol) | | Descriptor: | ATPase GET3, Protein GET2,Protein GET1, ZINC ION | | Authors: | McDowell, M.A, Wild, K, Sinning, I. | | Deposit date: | 2023-03-09 | | Release date: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (5 Å) | | Cite: | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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8ODV
 | | Chaetomium thermophilum Get1/Get2 heterotetramer in complex with a Get3 dimer (nanodisc) | | Descriptor: | ATPase GET3, Protein GET2,Protein GET1, ZINC ION | | Authors: | McDowell, M.A, Wild, K, Sinning, I. | | Deposit date: | 2023-03-09 | | Release date: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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5ONS
 | | Crystal structure of the minimal DENR-MCTS1 complex | | Descriptor: | Density-regulated protein, GLYCEROL, Malignant T-cell-amplified sequence 1, ... | | Authors: | Ahmed, Y.L, Sinning, I. | | Deposit date: | 2017-08-04 | | Release date: | 2018-05-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | DENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation.
PLoS Biol., 16, 2018
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8CR1
 | | Homo sapiens Get1/Get2 heterotetramer in complex with a Get3 dimer | | Descriptor: | ATPase ASNA1, Guided entry of tail-anchored proteins factor CAMLG,Guided entry of tail-anchored proteins factor 1,GET2-GET1, ZINC ION | | Authors: | McDowell, M.A, Heimes, M, Wild, K, Sinning, I. | | Deposit date: | 2023-03-07 | | Release date: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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3BB4
 | | Crystal structure of Toc33 from Arabidopsis thaliana in complex with Mg2+ and GMPPNP | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, T7I23.11 protein | | Authors: | Koenig, P, Sinning, I, Schleiff, E, Tews, I. | | Deposit date: | 2007-11-09 | | Release date: | 2008-04-01 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures.
Structure, 16, 2008
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1GSF
 | | GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH ETHACRYNIC ACID | | Descriptor: | ETHACRYNIC ACID, GLUTATHIONE TRANSFERASE A1-1 | | Authors: | L'Hermite, G, Sinning, I, Cameron, A.D, Jones, T.A. | | Deposit date: | 1995-06-09 | | Release date: | 1995-09-15 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3, 1995
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8CQZ
 | | Homo sapiens Get3 in complex with the Get1 cytoplasmic domain | | Descriptor: | ATPase ASNA1, Guided entry of tail-anchored proteins factor 1 | | Authors: | McDowell, M.A, Heimes, M, Wild, K, Saar, D, Sinning, I. | | Deposit date: | 2023-03-07 | | Release date: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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8CR2
 | | Homo sapiens Get1/Get2 heterotetramer (a3' deletion variant) in complex with a Get3 dimer | | Descriptor: | ATPase ASNA1, Guided entry of tail-anchored proteins factor CAMLG,Guided entry of tail-anchored proteins factor 1, ZINC ION | | Authors: | McDowell, M.A, Heimes, M, Wild, K, Sinning, I. | | Deposit date: | 2023-03-07 | | Release date: | 2023-11-29 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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9FPZ
 | | Human NatA-MAP2 80S ribosome complex | | Descriptor: | 28S rRNA, 5.8S rRNA (58-MER), 60S ribosomal protein L19, ... | | Authors: | Klein, M.A, Wild, K, Sinning, I. | | Deposit date: | 2024-06-14 | | Release date: | 2024-07-03 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (2.69 Å) | | Cite: | Multi-protein assemblies orchestrate co-translational enzymatic processing on the human ribosome.
Nat Commun, 15, 2024
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9FQ0
 | | Human NatA-NAC-MAP1 80S ribosome complex | | Descriptor: | 28S rRNA, 5.8S rRNA, 60S ribosomal protein L19, ... | | Authors: | Klein, M.A, Wild, K, Sinning, I. | | Deposit date: | 2024-06-14 | | Release date: | 2024-07-03 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (4.67 Å) | | Cite: | Multi-protein assemblies orchestrate co-translational enzymatic processing on the human ribosome.
Nat Commun, 15, 2024
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7Q72
 | | Structure of Pla1 in complex with Red1 | | Descriptor: | NURS complex subunit red1, Poly(A) polymerase pla1 | | Authors: | Soni, K, Wild, K, Sinning, I. | | Deposit date: | 2021-11-09 | | Release date: | 2022-12-07 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex.
Nat Commun, 14, 2023
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3BS6
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1QZW
 | | Crystal structure of the complete core of archaeal SRP and implications for inter-domain communication | | Descriptor: | 7S RNA, Signal recognition 54 kDa protein | | Authors: | Rosendal, K.R, Wild, K, Montoya, G, Sinning, I. | | Deposit date: | 2003-09-18 | | Release date: | 2003-11-18 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (4.1 Å) | | Cite: | Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication
Proc.Natl.Acad.Sci.USA, 100, 2003
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1QZX
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6ZQQ
 | | Structure of the Pmt3-MIR domain with bound ligands | | Descriptor: | GLYCEROL, PMT3 isoform 1 | | Authors: | Wild, K, Chiapparino, A, Hackmann, Y, Mortensen, S, Sinning, I. | | Deposit date: | 2020-07-10 | | Release date: | 2020-12-23 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Functional implications of MIR domains in protein O -mannosylation.
Elife, 9, 2020
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2PX0
 | | Crystal structure of FlhF complexed with GMPPNP/Mg(2+) | | Descriptor: | Flagellar biosynthesis protein flhF, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | Authors: | Bange, G, Wild, K, Sinning, I. | | Deposit date: | 2007-05-14 | | Release date: | 2007-09-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The crystal structure of the third signal-recognition particle GTPase FlhF reveals a homodimer with bound GTP.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2Q8K
 | | The crystal structure of Ebp1 | | Descriptor: | GLYCEROL, Proliferation-associated protein 2G4, SULFATE ION | | Authors: | Kowalinski, E, Bange, G, Wild, K, Sinning, I. | | Deposit date: | 2007-06-11 | | Release date: | 2007-09-25 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions.
Febs Lett., 581, 2007
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5TKY
 | | Crystal structure of the co-translational Hsp70 chaperone Ssb in the ATP-bound, open conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein | | Authors: | Gumiero, A, Gese, G.V, Weyer, F.A, Lapouge, K, Sinning, I. | | Deposit date: | 2016-10-10 | | Release date: | 2016-11-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain.
Nat Commun, 7, 2016
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7Q73
 | | Structure of Pla1 apo | | Descriptor: | GLYCEROL, Poly(A) polymerase pla1 | | Authors: | Soni, K, Wild, K, Sinning, I. | | Deposit date: | 2021-11-09 | | Release date: | 2022-12-07 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex.
Nat Commun, 14, 2023
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7Q74
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1SMB
 | | Crystal Structure of Golgi-Associated PR-1 protein | | Descriptor: | 17kD fetal brain protein | | Authors: | Serrano, R.L, Kuhn, A, Hendricks, A, Helms, J.B, Sinning, I, Groves, M.R. | | Deposit date: | 2004-03-08 | | Release date: | 2004-09-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism
J.Mol.Biol., 339, 2004
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8QDQ
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8QDR
 | | Vitis vinifera dimeric 13S-lipoxygenase LOXA in a detergent bound open conformation | | Descriptor: | 1,2-ETHANEDIOL, 3,6,12,15,18,21,24-HEPTAOXAHEXATRIACONTAN-1-OL, FE (III) ION, ... | | Authors: | Wild, K, Sinning, I. | | Deposit date: | 2023-08-30 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Vitis vinifera lipoxygenase LoxA is an allosteric dimer activated by lipidic surfaces.
J.Mol.Biol., 2024
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