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PDB: 627 件

2AR9
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Crystal structure of a dimeric caspase-9
分子名称: Caspase-9, D-MALATE
著者Chao, Y, Shiozaki, E.N, Srinivassula, S.M, Rigotti, D.J, Fairman, R, Shi, Y.
登録日2005-08-19
公開日2005-10-11
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Engineering a Dimeric Caspase-9: A Re-Evaluation of the Induced Proximity Model for Caspase Activation
PLOS BIOL., 3, 2005
4Y6K
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Complex structure of presenilin homologue PSH bound to an inhibitor
分子名称: N-{(2R,4S,5S)-2-benzyl-5-[(tert-butoxycarbonyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-leucyl-L-phenylalaninamide, Uncharacterized protein PSH
著者Dang, S, Wu, S, Wang, J, Shi, Y.
登録日2015-02-13
公開日2015-03-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.855 Å)
主引用文献Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH
Proc.Natl.Acad.Sci.USA, 112, 2015
2HV6
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Crystal structure of the phosphotyrosyl phosphatase activator
分子名称: MAGNESIUM ION, Protein phosphatase 2A, regulatory subunit B
著者Chao, Y, Jeffrey, P.D, Shi, Y.
登録日2006-07-27
公開日2006-08-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure and mechanism of the phosphotyrosyl phosphatase activator.
Mol.Cell, 23, 2006
2HV7
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Crystal structure of phosphotyrosyl phosphatase activator bound to ATPgammaS
分子名称: ADENOSINE-5'-DIPHOSPHATE, Protein phosphatase 2A, regulatory subunit B
著者Chao, Y, Jeffrey, J.D, Shi, Y.
登録日2006-07-27
公開日2006-08-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure and mechanism of the phosphotyrosyl phosphatase activator.
Mol.Cell, 23, 2006
2OSG
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Solution Structure and Binding Property of the Domain-swapped Dimer of ZO2PDZ2
分子名称: Tight junction protein ZO-2
著者Wu, J.W, Yang, Y.S, Zhang, J.H, Ji, P, Wu, J.H, Shi, Y.Y.
登録日2007-02-05
公開日2007-09-25
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Domain-swapped Dimerization of the Second PDZ Domain of ZO2 May Provide a Structural Basis for the Polymerization of Claudins
J.Biol.Chem., 282, 2007
2IE3
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Structure of the Protein Phosphatase 2A Core Enzyme Bound to Tumor-inducing Toxins
分子名称: MANGANESE (II) ION, Protein Phosphatase 2, regulatory subunit A (PR 65), ...
著者Xing, Y, Xu, Y, Chen, Y, Jeffrey, P.D, Chao, Y, Shi, Y.
登録日2006-09-17
公開日2006-11-07
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
Cell(Cambridge,Mass.), 127, 2006
2IE4
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Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid
分子名称: MANGANESE (II) ION, OKADAIC ACID, Protein Phosphatase 2, ...
著者Xing, Y, Xu, Y, Chen, Y, Jeffrey, P.D, Chao, Y, Shi, Y.
登録日2006-09-17
公開日2006-11-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
Cell(Cambridge,Mass.), 127, 2006
6XYO
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Multiple system atrophy Type I alpha-synuclein filament
分子名称: Alpha-synuclein
著者Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M.
登録日2020-01-30
公開日2020-02-12
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Structures of alpha-synuclein filaments from multiple system atrophy.
Nature, 585, 2020
6XYP
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Multiple system atrophy Type II-1 alpha-synuclein filament
分子名称: Alpha-synuclein
著者Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M.
登録日2020-01-30
公開日2020-02-12
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.29 Å)
主引用文献Structures of alpha-synuclein filaments from multiple system atrophy.
Nature, 585, 2020
2F7X
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Protein Kinase A bound to (S)-2-(1H-Indol-3-yl)-1-[5-((E)-2-pyridin-4-yl-vinyl)-pyridin-3-yloxymethyl]-ethylamine
分子名称: (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE, PKI, inhibitory peptide, ...
著者Li, Q, Li, T, Zhu, G.D, Gong, J, Claibone, A, Dalton, C, Luo, Y, Johnson, E.F, Shi, Y, Liu, X, Klinghofer, V, Bauch, J.L, Marsh, K.C, Bouska, J.J, Arries, S, De Jong, R, Oltersdorf, T, Stoll, V.S, Jakob, C.G, Rosenberg, S.H, Giranda, V.L.
登録日2005-12-01
公開日2006-06-27
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation.
Bioorg.Med.Chem.Lett., 16, 2006
2F1S
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Crystal Structure of a Viral FLIP MC159
分子名称: Viral CASP8 and FADD-like apoptosis regulator
著者Li, F.-Y, Jeffrey, P.D, Yu, J.W, Shi, Y.
登録日2005-11-15
公開日2005-11-29
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal Structure of a Viral FLIP: INSIGHTS INTO FLIP-MEDIATED INHIBITION OF DEATH RECEPTOR SIGNALING.
J.Biol.Chem., 281, 2006
2F7Z
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Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-ehylamine
分子名称: (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE, PKI, inhibitory peptide, ...
著者Li, Q, Woods, K.W, Thomas, S, Zhu, G.D, Packard, G, Fisher, J, Li, T, Gong, J, Dinges, J, Song, X, Abrams, J, Luo, Y, Johnson, E.F, Shi, Y, Liu, X, Klinghofer, V, Des Jong, R, Oltersdorf, T, Stoll, V.S, Jakob, C.G, Rosenberg, S.H, Giranda, V.L.
登録日2005-12-01
公開日2006-06-27
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
Bioorg.Med.Chem.Lett., 16, 2006
4M9S
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crystal structure of CED-4 bound CED-3 fragment
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ...
著者Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G.
登録日2013-08-15
公開日2013-10-23
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (3.207 Å)
主引用文献Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
2AIN
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Solution structure of the AF-6 PDZ domain complexed with the C-terminal peptide from the Bcr protein
分子名称: 6-mer peptide from Breakpoint cluster region protein, Afadin
著者Chen, Q, Wu, J, Shi, Y.
登録日2005-07-30
公開日2006-07-18
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure and backbone dynamics of the AF-6 PDZ domain/Bcr peptide complex.
Protein Sci., 16, 2007
2AX5
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Solution Structure of Urm1 from Saccharomyces Cerevisiae
分子名称: Hypothetical 11.0 kDa protein in FAA3-MAS3 intergenic region
著者Xu, J, Huang, H, Zhang, J, Wu, J, Shi, Y.
登録日2005-09-03
公開日2006-06-27
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of Urm1 and its implications for the origin of protein modifiers.
Proc.Natl.Acad.Sci.Usa, 103, 2006
1JD6
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Crystal Structure of DIAP1-BIR2/Hid Complex
分子名称: APOPTOSIS 1 INHIBITOR, ZINC ION, head involution defective protein
著者Wu, J.W, Cocina, A.E, Chai, J, Hay, B.A, Shi, Y.
登録日2001-06-12
公開日2001-12-05
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides.
Mol.Cell, 8, 2001
1JD4
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Crystal Structure of DIAP1-BIR2
分子名称: APOPTOSIS 1 INHIBITOR, ZINC ION
著者Wu, J.W, Cocina, A.E, Chai, J, Hay, B.A, Shi, Y.
登録日2001-06-12
公開日2001-12-05
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides.
Mol.Cell, 8, 2001
1JD5
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Crystal Structure of DIAP1-BIR2/GRIM
分子名称: APOPTOSIS 1 INHIBITOR, ZINC ION, cell death protein GRIM
著者Wu, J.W, Cocina, A.E, Chai, J, Hay, B.A, Shi, Y.
登録日2001-06-12
公開日2001-12-05
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides.
Mol.Cell, 8, 2001
4YY0
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The structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HA1, HA2
著者Wang, F, Qi, J, Bi, Y, Zhang, W, Wang, M, Wang, M, Liu, J, Yan, J, Shi, Y, Gao, G.F.
登録日2015-03-23
公開日2016-03-23
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013)
To Be Published
1K86
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Crystal structure of caspase-7
分子名称: caspase-7
著者Chai, J, Wu, Q, Shiozaki, E, Srinivasa, S.M, Alnemri, E.S, Shi, Y.
登録日2001-10-23
公開日2001-11-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding
Cell(Cambridge,Mass.), 107, 2001
1K88
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Crystal structure of procaspase-7
分子名称: procaspase-7
著者Chai, J, Wu, Q, Shiozaki, E, Srinivasa, S.M, Alnemri, E.S, Shi, Y.
登録日2001-10-23
公開日2001-11-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding
Cell(Cambridge,Mass.), 107, 2001
5GJR
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An atomic structure of the human 26S proteasome
分子名称: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ...
著者Huang, X.L, Luan, B, Wu, J.P, Shi, Y.G.
登録日2016-07-01
公開日2016-09-07
最終更新日2019-10-09
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献An atomic structure of the human 26S proteasome.
Nat. Struct. Mol. Biol., 23, 2016
7XKC
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Crystal structure of Daucus Carrot hypoglycemic peptide (DCHP)
分子名称: DCHP, SULFATE ION
著者Guo, T, Ren, J.Q, Wang, L, Shi, Y.W, Feng, W.
登録日2022-04-19
公開日2022-05-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Characterization of a thermostable, protease-tolerant inhibitor of alpha-glycosidase from carrot: A potential oral additive for treatment of diabetes.
Int.J.Biol.Macromol., 209, 2022
3RES
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BU of 3res by Molmil
Crystal structure of E coli Hfq in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Protein hfq
著者Wang, W.W, Wu, J.H, Shi, Y.Y.
登録日2011-04-05
公開日2011-10-19
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Cooperation of Escherichia coli Hfq hexamers in DsrA binding.
Genes Dev., 25, 2011
1MR1
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Crystal Structure of a Smad4-Ski Complex
分子名称: Mothers against decapentaplegic homolog 4, Ski oncogene, ZINC ION
著者Wu, J.-W, Krawitz, A.R, Chai, J, Li, W, Zhang, F, Luo, K, Shi, Y.
登録日2002-09-17
公開日2003-01-21
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Structural Mechanism of Smad4 Recognition by the Nuclear Oncoprotein Ski: Insights on Ski-mediated Repression of TGF-beta Signaling
Cell(Cambridge,Mass.), 111, 2002

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