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PDB: 243 results

2JRY
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Structure and Sodium Channel Activity of an Excitatory I1-Superfamily Conotoxin
Descriptor: I-superfamily conotoxin r11a
Authors:Buczek, O, Wei, D, Babon, J, Yang, X, Fiedler, B, Chen, P, Yoshikami, D, Olivera, B, Bulaj, G, Norton, R.
Deposit date:2007-06-29
Release date:2007-10-23
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structure and sodium channel activity of an excitatory I1-superfamily conotoxin.
Biochemistry, 46, 2007
3UUO
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The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as PDE10 inhibitors for the treatment of Schizophrenia
Descriptor: 6-methoxy-3,8-dimethyl-4-(piperazin-1-yl)-1H-pyrazolo[3,4-b]quinoline, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Ho, G.D, Yang, S, Smotryski, J, Bercovici, A, Nechuta, T, Smith, E.M, McElroy, W, Tan, Z, Tulshian, D, Mckittrick, B, Greenlee, W.J, Hruza, A, Xiao, L, Rindgen, D, Guzzi, M, Zhang, X, Bleickardt, C, Mullins, D, Hodgson, R.
Deposit date:2011-11-28
Release date:2012-01-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.
Bioorg.Med.Chem.Lett., 22, 2012
3UI7
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Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia
Descriptor: 6-methoxy-3,8-dimethyl-4-(morpholin-4-ylmethyl)-1H-pyrazolo[3,4-b]quinoline, MAGNESIUM ION, ZINC ION, ...
Authors:Yang, S, Smotryski, J, Mcelroy, W, Ho, G, Tulshian, D, Greenlee, W.J, Hodgson, R, Xiao, L, Hruza, A.
Deposit date:2011-11-04
Release date:2011-12-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.
Bioorg.Med.Chem.Lett., 22, 2012
3KYR
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BU of 3kyr by Molmil
Bace-1 in complex with a norstatine type inhibitor
Descriptor: 3-[[(2S)-2-[[[(2S)-2-[[(2S)-2-[[(2S)-2-azanyl-3-(1H-1,2,3,4-tetrazol-5-ylcarbonylamino)propanoyl]amino]-3-methyl-butanoyl]amino]-4-methyl-pentanoyl]amino]methyl]-2-hydroxy-4-phenyl-butanoyl]amino]benzoic acid, Beta-secretase 1
Authors:Lindberg, J.D, Borkakoti, N, Derbyshire, D, Nystrom, S.
Deposit date:2009-12-07
Release date:2010-12-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Investigation of a-phenylnorstatine and a-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibiotrs
To be Published
3WFR
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BU of 3wfr by Molmil
tRNA processing enzyme complex 2
Descriptor: CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
Authors:Yamashita, S, Takeshita, D, Tomita, K.
Deposit date:2013-07-23
Release date:2014-01-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.501 Å)
Cite:Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase
Structure, 22, 2014
3WFS
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tRNA processing enzyme complex 3
Descriptor: Poly A polymerase, RNA (74-MER), SULFATE ION
Authors:Yamashita, S, Takeshita, D, Tomita, K.
Deposit date:2013-07-23
Release date:2014-01-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.311 Å)
Cite:Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase
Structure, 22, 2014
2KN0
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BU of 2kn0 by Molmil
Solution NMR Structure of xenopus Fn14
Descriptor: Fn14
Authors:Pellegrini, M, Willen, L, Perroud, M, Krushinskie, D, Strauch, K, Cuervo, H, Sun, Y, Day, E.S, Schneider, P, Zheng, T.S.
Deposit date:2009-08-11
Release date:2011-06-29
Last modified:2013-05-01
Method:SOLUTION NMR
Cite:Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions.
Febs J., 280, 2013
2KN1
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BU of 2kn1 by Molmil
Solution NMR Structure of BCMA
Descriptor: Tumor necrosis factor receptor superfamily member 17
Authors:Pellegrini, M, Willen, L, Perroud, M, Krushinskie, D, Strauch, K, Cuervo, H, Sun, Y, Day, E.S, Schneider, P, Zheng, T.S.
Deposit date:2009-08-11
Release date:2011-02-23
Last modified:2013-05-01
Method:SOLUTION NMR
Cite:Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions.
Febs J., 280, 2013
2KMZ
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BU of 2kmz by Molmil
NMR Structure of hFn14
Descriptor: Tumor necrosis factor receptor superfamily member 12A
Authors:Pellegrini, M, Willen, L, Perroud, M, Krushinskie, D, Strauch, K, Cuervo, H, Sun, Y, Day, E.S, Schneider, P, Zheng, T.S.
Deposit date:2009-08-10
Release date:2011-06-29
Last modified:2013-05-01
Method:SOLUTION NMR
Cite:Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions.
Febs J., 280, 2013
3AK4
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BU of 3ak4 by Molmil
Crystal structure of NADH-dependent quinuclidinone reductase from agrobacterium tumefaciens
Descriptor: NADH-dependent quinuclidinone reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Miyakawa, T, Kataoka, M, Takeshita, D, Nomoto, F, Nagata, K, Shimizu, S, Tanokura, M.
Deposit date:2010-07-07
Release date:2011-07-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of NADH-dependent quinuclidinone reductase from Agrobacterium tumefaciens
To be Published
4DPF
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BU of 4dpf by Molmil
BACE-1 in complex with a HEA-macrocyclic type inhibitor
Descriptor: Beta-secretase 1, N-[(4S,8E,11S)-4-[(1R)-1-hydroxy-2-{[3-(propan-2-yl)benzyl]amino}ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(18),8,14,16-tetraen-16-yl]-N-methylmethanesulfonamide
Authors:Lindberg, J, Borkakoti, N, Derbyshire, D.
Deposit date:2012-02-13
Release date:2012-07-11
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: design, synthesis and X-ray crystal structures of enzyme inhibitor complexes.
Bioorg.Med.Chem., 20, 2012
4DPI
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BU of 4dpi by Molmil
BACE-1 in complex with HEA-macrocyclic inhibitor, MV078512
Descriptor: (4S,8E,11R)-4-[(1R)-1-hydroxy-2-{[3-(propan-2-yl)benzyl]amino}ethyl]-16-methyl-11-phenyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(18),8,14,16-tetraene-2,13-dione, Beta-secretase 1
Authors:Lindberg, J, Borkakoti, N, Derbyshire, D.
Deposit date:2012-02-13
Release date:2012-07-11
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: design, synthesis and X-ray crystal structures of enzyme inhibitor complexes.
Bioorg.Med.Chem., 20, 2012
4GMI
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BU of 4gmi by Molmil
BACE-1 in complex with HEA-type macrocyclic inhibitor, MV078571
Descriptor: (4S,8E)-4-[(1R)-2-{[2-(5-tert-butyl-1,3-oxazol-2-yl)propan-2-yl]amino}-1-hydroxyethyl]-16-methyl-6-oxa-3-azabicyclo[12.3.1]octadeca-1(18),8,14,16-tetraene-2,13-dione, ACETATE ION, Beta-secretase 1, ...
Authors:Lindberg, J.D, Derbyshire, D.
Deposit date:2012-08-16
Release date:2013-09-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design and synthesis of novel BACE-1 inhibitors
To be Published
3AQN
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BU of 3aqn by Molmil
Complex structure of bacterial protein (apo form II)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Poly(A) polymerase
Authors:Toh, Y, Takeshita, D, Tomita , K.
Deposit date:2010-11-09
Release date:2011-02-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Mechanism for the alteration of the substrate specificities of template-independent RNA polymerases
Structure, 19, 2011
3AQL
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BU of 3aql by Molmil
Structure of bacterial protein (apo form II)
Descriptor: GLYCEROL, MAGNESIUM ION, Poly(A) polymerase
Authors:Toh, Y, Takeshita, D, Tomita , K.
Deposit date:2010-11-09
Release date:2011-02-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanism for the alteration of the substrate specificities of template-independent RNA polymerases
Structure, 19, 2011
3AQK
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BU of 3aqk by Molmil
Structure of bacterial protein (apo form I)
Descriptor: Poly(A) polymerase
Authors:Toh, Y, Takeshita, D, Tomita , K.
Deposit date:2010-11-09
Release date:2011-02-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Mechanism for the alteration of the substrate specificities of template-independent RNA polymerases
Structure, 19, 2011
3AQM
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BU of 3aqm by Molmil
Structure of bacterial protein (form II)
Descriptor: MAGNESIUM ION, Poly(A) polymerase
Authors:Toh, Y, Takeshita, D, Tomita , K.
Deposit date:2010-11-09
Release date:2011-02-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Mechanism for the alteration of the substrate specificities of template-independent RNA polymerases
Structure, 19, 2011
1WRI
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BU of 1wri by Molmil
Crystal Structure of Ferredoxin isoform II from E. arvense
Descriptor: BENZAMIDINE, FE2/S2 (INORGANIC) CLUSTER, Ferredoxin II
Authors:Kurisu, G, Nishiyama, D, Kusunoki, M, Fujikawa, S, Katoh, M, Hanke, G.T, Hase, T, Teshima, K.
Deposit date:2004-10-18
Release date:2004-11-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:A structural basis of Equisetum arvense ferredoxin isoform II producing an alternative electron transfer with ferredoxin-NADP+ reductase.
J.Biol.Chem., 280, 2005

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數據於2024-06-19公開中

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