4TWY
 
 | | Structure of SARS-3CL protease complex with a phenylbenzoyl (S,R)-N-decalin type inhibitor | | 分子名称: | (2S)-2-({[(3S,4aR,8aS)-2-(biphenyl-4-ylcarbonyl)decahydroisoquinolin-3-yl]methyl}amino)-3-(1H-imidazol-5-yl)propanal, 3C-like proteinase | | 著者 | Akaji, K, Teruya, K, Shimamoto, Y, Sanjho, A, Yamashita, E, Nakagawa, A. | | 登録日 | 2014-07-02 | | 公開日 | 2015-02-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors
Bioorg.Med.Chem., 23, 2015
|
|
5C5N
 | | Structure of SARS-3CL protease complex with a phenyl-beta-alanyl (R,S)-N-decalin type inhibitor | | 分子名称: | (2S)-3-(1H-imidazol-5-yl)-2-({[(3R,4aS,8aR)-2-(N-phenyl-beta-alanyl)decahydroisoquinolin-3-yl]methyl}amino)propanal, 3C-like proteinase | | 著者 | Akaji, K, Teruya, K, Shimamoto, Y, Sanjho, A, Yamashita, E, Nakagawa, A. | | 登録日 | 2015-06-21 | | 公開日 | 2016-06-22 | | 最終更新日 | 2020-01-29 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Fused-ring structure of N-decalin as a novel scaffold for SARS 3CL protease inhibitors
to be published
|
|
5C5O
 | | Structure of SARS-3CL protease complex with a phenyl-beta-alanyl (S,R)-N-decalin type inhibitor | | 分子名称: | (2S)-3-(1H-imidazol-5-yl)-2-({[(3S,4aR,8aS)-2-(N-phenyl-beta-alanyl)decahydroisoquinolin-3-yl]methyl}amino)propanal, 3C-like proteinase | | 著者 | Akaji, K, Teruya, K, Shimamoto, Y, Sanjho, A, Yamashita, E, Nakagawa, A. | | 登録日 | 2015-06-21 | | 公開日 | 2016-06-22 | | 最終更新日 | 2020-01-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Fused-ring structure of N-decalin as a novel scaffold for SARS 3CL protease inhibitors
to be published
|
|
4TRY
 | | Structure of BACE1 complex with a HEA-type inhibitor | | 分子名称: | Beta-secretase 1, GLU-ILE-TIH-THC-NVA | | 著者 | Akaji, K, Teruya, K, Akiyama, T, Sanjho, A, Yamashita, E, Nakagawa, A. | | 登録日 | 2014-06-18 | | 公開日 | 2015-07-29 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structure of BACE1 complex with an anti-HMC-type inhibitor
to be published
|
|
4WY3
 | | Structure of SARS-3CL protease complex with a phenylbenzoyl (R,S)-N-decalin type inhibitor | | 分子名称: | (2S)-2-({[(3R,4aS,8aR)-2-(biphenyl-4-ylcarbonyl)decahydroisoquinolin-3-yl]methyl}amino)-3-(1H-imidazol-5-yl)propanal, 3C-like proteinase | | 著者 | Akaji, K, Teruya, K, Shimamoto, Y, Sanjho, A, Yamashita, E, Nakagawa, A. | | 登録日 | 2014-11-15 | | 公開日 | 2015-02-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors.
Bioorg.Med.Chem., 23, 2015
|
|
4TRW
 | | Structure of BACE1 complex with a syn-HEA-type inhibitor | | 分子名称: | Beta-secretase 1, L-alpha-glutamyl-L-isoleucyl-N-[(2R,3S)-1-{[(1S)-1-carboxybutyl]amino}-2-hydroxy-5-methylhexan-3-yl]-3-thiophen-2-yl-L-alaninamide | | 著者 | Akaji, K, Teruya, K, Akiyama, T, Sanjho, A, Yamashita, E, Nakagawa, A. | | 登録日 | 2014-06-18 | | 公開日 | 2015-07-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors
Bioorg.Med.Chem., 23, 2015
|
|
4TRZ
 | | Structure of BACE1 complex with 2-thiophenyl HEA-type inhibitor | | 分子名称: | 2-thiophenyl HEA-type inhibitor, Beta-secretase 1 | | 著者 | Akaji, K, Teruya, K, Akiyama, T, Sanjho, A, Yamashita, E, Nakagawa, A. | | 登録日 | 2014-06-18 | | 公開日 | 2015-07-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors
Bioorg.Med.Chem., 23, 2015
|
|
4TWW
 | | Structure of SARS-3CL protease complex with a Bromobenzoyl (S,R)-N-decalin type inhibitor | | 分子名称: | (2S)-2-({[(3S,4aR,8aS)-2-(4-bromobenzoyl)decahydroisoquinolin-3-yl]methyl}amino)-3-(1H-imidazol-5-yl)propanal, 3C-like proteinase | | 著者 | Akaji, K, Teruya, K, Shimamoto, Y, Sanjho, A, Yamashita, E, Nakagawa, A. | | 登録日 | 2014-07-02 | | 公開日 | 2015-02-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors
Bioorg.Med.Chem., 23, 2015
|
|
3AW0
 | | Structure of SARS 3CL protease with peptidic aldehyde inhibitor | | 分子名称: | 3C-Like Proteinase, peptide ACE-SER-ALA-VAL-LEU-HIS-H | | 著者 | Akaji, K, Konno, H, Mitsui, H, Teruya, K, Hattori, Y, Ozaki, T, Kusunoki, M, Sanjho, A. | | 登録日 | 2011-03-09 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors.
J.Med.Chem., 54, 2011
|
|
3AW1
 | | Structure of SARS 3CL protease auto-proteolysis resistant mutant in the absent of inhibitor | | 分子名称: | 3C-Like Proteinase | | 著者 | Akaji, K, Konno, H, Mitsui, H, Teruya, K, Hattori, Y, Ozaki, T, Kusunoki, M, Sanjho, A. | | 登録日 | 2011-03-09 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors.
J.Med.Chem., 54, 2011
|
|
3ATW
 | | Structure-Based Design, Synthesis, Evaluation of Peptide-mimetic SARS 3CL Protease Inhibitors | | 分子名称: | 3C-Like Proteinase, peptide ACE-THR-VAL-ALC-HIS-H | | 著者 | Akaji, K, Konno, H, Mitsui, H, Teruya, K, Hattori, Y, Ozaki, T, Kusunoki, M, Sanjho, A. | | 登録日 | 2011-01-20 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors.
J.Med.Chem., 54, 2011
|
|
3AVZ
 | | Structure of SARS 3CL protease with peptidic aldehyde inhibitor containing cyclohexyl side chain | | 分子名称: | 3C-Like Proteinase, peptide ACE-SER-ALA-VAL-ALC-HIS-H | | 著者 | Akaji, K, Konno, H, Mitsui, H, Teruya, K, Hattori, Y, Ozaki, T, Kusunoki, M, Sanjho, A. | | 登録日 | 2011-03-09 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors.
J.Med.Chem., 54, 2011
|
|
