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PDB: 6 件
7WM4
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BU of 7wm4 by Molmil
Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RNA (81-MER), ...
著者Sakaniwa, K, Ohto, U, Shimizu, T.
登録日2022-01-14
公開日2023-01-25
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction.
Nat Commun, 14, 2023
7CRF
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BU of 7crf by Molmil
Crystal structure of human TLR8 in complex with CU-CPD107
分子名称: 1-[2-(ethoxymethyl)-4-iodanyl-5-phenyl-imidazol-1-yl]-2-methyl-propan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ...
著者Sakaniwa, K, Tanji, H, Ohto, U, Shimizu, T.
登録日2020-08-13
公開日2021-06-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists.
Nat Commun, 12, 2021
8WX3
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BU of 8wx3 by Molmil
Cryo-EM structure of human SLC15A4 (outward-facing open)
分子名称: Solute carrier family 15 member 4
著者Sakaniwa, K, Zhang, Z, Ohto, U, Shimizu, T.
登録日2023-10-27
公開日2023-12-06
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献Cryo-EM structure of human SLC15A4 (outward-facing open)
To Be Published
8WX4
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BU of 8wx4 by Molmil
Cryo-EM structure of human SLC15A4 in complex with Lys-Leu (outward-facing open)
分子名称: LEUCINE, LYSINE, Solute carrier family 15 member 4
著者Sakaniwa, K, Zhang, Z, Ohto, U, Shimizu, T.
登録日2023-10-27
公開日2023-12-13
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Cryo-EM structure of human SLC15A4 in complex with Lys-Leu (outward-facing open)
To Be Published
6KYA
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BU of 6kya by Molmil
Crystal structure of human TLR8 in complex TH1027
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-methylsulfanyl-4-(3,4,5-trimethylphenyl)-1,2,4-triazol-3-yl]propan-1-ol, ...
著者Tanji, H, Sakaniwa, K, Ohto, U, Shimizu, T.
登録日2019-09-17
公開日2020-05-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.
J.Med.Chem., 63, 2020
7YTX
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BU of 7ytx by Molmil
Crystal structure of TLR8 in complex with its antagonist
分子名称: (2R,6R)-4-(8-cyanoquinolin-5-yl)-N-[(3S,4R)-4-fluoranylpyrrolidin-3-yl]-6-methyl-morpholine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Shimizu, T, Sakaniwa, K.
登録日2022-08-16
公開日2023-09-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A novel Toll-like receptor 7/8-specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus.
Eur.J.Pharmacol., 957, 2023

219515

件を2024-05-08に公開中

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